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Cited by 75Effects and risks of endocrine disrupting chemicalsSperm and Testicular FunctionPesticide Exposure and Toxicity

Phthalate exposure, even below US EPA reference doses, was associated with semen quality and reproductive hormones: Prospective MARHCS study in general population

Chen, Qing, Yang, Huan, Zhou, Niya, Sun, Lei, Bao, Huaqiong, Tan, Lu, Chen, Hongqiang, Ling, Xi +15 more·2017·Environment International
DOI 10.1016/j.envint.2017.04.005
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Abstract

Background Environment-Protection-Agency Reference Doses (EPA RfDs) for phthalate intakes are based on limited evidence, especially regarding low-dose male-reproductive toxicity. This study investigates the association between phthalate exposure and semen parameters and reproductive hormones in a general population with low phthalate exposure compared to the EPA RfDs. Methods The MARHCS (Male-Reproductive-Health-in-Chongqing-College-Students) cohort recruited 796 male students, who experienced a relocation of campuses and shifting environmental exposure. Urine, semen and blood before and after the relocation was collected and investigated for: (1) the associations between 13 urinary phthalate metabolites and 11 semen/hormone outcomes (five semen parameters including semen volume, sperm concentration, total sperm number, progressive motility, normal morphology) and six serum reproductive hormones including estradiol, follicle-stimulating hormone, luteinizing hormone, prolactin, progesterone, testosterone; (2) re-analysis of the metabolite-outcome associations in the subjects with estimated phthalate intakes below the RfDs; (3) a change in phthalate metabolites and change in semen/hormone outcomes after the relocation; (4) the association between these changes. Results (1) All but two semen/hormone outcomes were associated with at least one phthalate metabolite, e.g., each quartile monoethyl phthalate was associated with a 5.3%, 5.7% and 2.6% decrease of sperm concentration, to…

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Authors
Chen, Q., Yang, H., Zhou, N., Sun, L., Bao, H., Tan, L., Chen, H., Ling, X., Zhang, G., Huang, L., Li, L., Ma, M., Yang, H., Wang, X., Zou, P., Peng, K., Liu, T., Shi, X., Feng, D., Zhou, Z., Ao, L., Cui, Z., & Cao, J.
Affiliations
  • Army Medical University (CN)
  • Chongqing Population and Family Planning Science and Technology Research Institute (CN)
  • National Institute of Measurement and Testing Technology (CN)
Corresponding author
Cao, Jia
ORCID
Venue
Environment International
Publisher
Elsevier BV
Published
2017-07
Volume
104
Pages
58-68
ISSN
0160-4120 (ISSN-L)
DOI
10.1016/j.envint.2017.04.005
OpenAlex
W2609083053
Cited by
75
References
1
Citations by year
2026: 8 · 2025: 9 · 2024: 7 · 2023: 4 · 2022: 10 · 2021: 12 · 2020: 8 · 2019: 6 · 2018: 9 · 2017: 2
FWCI
3.53
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Environment International (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
  • National Natural Science Foundation of China (81130051, 81402660, 81202276, 81502788)
  • National Scientific and Technological Support Program (2013BAI12B02)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Pesticide Exposure and Toxicity
Keywords
phthalate exposure, semen quality, reproductive hormones, urinary phthalate metabolites, monoethyl phthalate, mono(2-ethylhexyl) phthalate, sperm concentration, sperm motility, sperm morphology, male reproductive toxicity, estradiol, testosterone, luteinizing hormone, university students
MeSH terms
Adult, Environmental Monitoring, Environmental Pollutants, Hormones, Humans, Male, Phthalic Acids, Prospective Studies, Semen, Sperm Count, Spermatozoa, United States, United States Environmental Protection Agency, Semen Analysis, Young Adult

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