The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Human exposure to polycyclic aromatic hydrocarbons: Metabolomics perspective
Abstract
Polycyclic aromatic hydrocarbons (PAHs) are organic contaminants exhibiting carcinogenic toxicity. They are widespread in the environment, especially in urban areas. Humans are exposed to PAHs via inhalation, ingestion and dermal contact. Though much research has investigated their toxicity, little is known regarding the metabolic responses in humans after exposing to PAHs. However, those studies are important since PAHs become carcinogenic after metabolic activation by humans as indirect-acting carcinogens. As such, it is important to study their metabolism in humans based on metabolomics analysis. The goal of metabolomics study is to obtain a comprehensive view of metabolic reactions in humans after exposing to PAHs to better control the underlying metabolisms and reduce their genotoxicity. This article reviewed the biomarkers, analytical techniques including nuclear magnetic resonance and mass spectrometry, big data multivariate statistical analysis, and animal models that have been utilized to better understand the biological effects of PAHs, PAH-derivatives, and their metabolites and biotransformation products on humans.
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Cites
Abdel-Shafy, H. I., & Mansour, M. S. M. (2016) · Egyptian Journal of Petroleum · doi:10.1016/j.ejpe.2015.03.011 · Cited by 3,577
Metabolomics: beyond biomarkers and towards mechanisms
Johnson, C. H., Ivanisevic, J., & Siuzdak, G. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.25 · Cited by 2,829
A review of airborne polycyclic aromatic hydrocarbons (PAHs) and their human health effects
Kim, K.-H., Jahan, S. A., Kabir, E., & Brown, R. J. C. (2013) · Environment International · doi:10.1016/j.envint.2013.07.019 · Cited by 2,420
Multivariate Analysis in Metabolomics
Worley, B., & Powers, R. (2012) · Current Metabolomics · doi:10.2174/2213235x11301010092 · Cited by 1,348
Nebert, D. W., Dalton, T. P., Okey, A. B., & Gonzalez, F. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r400004200 · Cited by 1,182
Metabolic activation of polycyclic and heterocyclic aromatic hydrocarbons and DNA damage: A review
Xue, W., & Warshawsky, D. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.11.006 · Cited by 895
Statistical strategies for avoiding false discoveries in metabolomics and related experiments
Broadhurst, D. I., & Kell, D. B. (2007) · Metabolomics · doi:10.1007/s11306-006-0037-z · Cited by 817
Environmental metabolomics: a critical review and future perspectives
Bundy, J. G., Davey, M. P., & Viant, M. R. (2009) · Metabolomics · doi:10.1007/s11306-008-0152-0 · Cited by 812
Polycyclic Aromatic Hydrocarbons: From Metabolism to Lung Cancer
Moorthy, B., Chu, C., & Carlin, D. J. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv040 · Cited by 801
Rochfort, S. (2005) · Journal of Natural Products · doi:10.1021/np050255w · Cited by 465
Cited by
Fan, C., Cao, X., Han, T., Pei, H., Hu, G., Wang, W., & Qian, C. (2019) · Microchimica Acta · doi:10.1007/s00604-019-3651-y · Cited by 54
Metadata
- Authors
- Gao, P., da Silva, E., Hou, L., Denslow, N. D., Xiang, P., & Ma, L. Q.
- Venue
- Environment International
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 119
- Pages
- 466-477
- ISSN
- 0160-4120 (ISSN-L)
- OpenAlex
- W2884469097
- Cited by
- 258
- References
- 53
- FWCI
- 8.40
- Type
- journal article
- Language
- en
- Open access
- closed
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