The DOI matches its Crossref record; 132 of the 132 references it cites were found in a registry or an index.
Assessing the human health risks of perfluorooctane sulfonate by in vivo and in vitro studies
Open accessAbstract
The wide use of perfluorooctane sulfonate (PFOS) has led to increasing concern about its human health risks over the past decade. In vivo and in vitro studies are important and effective means to ascertain the toxic effects of PFOS on humans and its toxic mechanisms. This article systematically reviews the human health risks of PFOS based on the currently known facts found by in vivo and in vitro studies from 2008 to 2018. Exposure to PFOS has caused hepatotoxicity, neurotoxicity, reproductive toxicity, immunotoxicity, thyroid disruption, cardiovascular toxicity, pulmonary toxicity, and renal toxicity in laboratory animals and many in vitro human systems. These results and related epidemiological studies confirmed the human health risks of PFOS, especially for exposure via food and drinking water. Oxidative stress and physiological process disruption based on fatty acid similarity were widely studied mechanisms of PFOS toxicity. Future research for assessing the human health risks of PFOS is recommended in the chronic toxicity and molecular mechanisms, the application of various omics, and the integration of toxicological and epidemiological data. • Assessing human health risks of PFOS by in vivo and in vitro studies are reviewed. • Exposure to PFOS can cause significant human health risks. • The chronic toxicity and molecular mechanisms need further study. • Integration of the toxicological and epidemiological data is recommended.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000100 · Cited by 28,164
Mitochondrial formation of reactive oxygen species
Turrens, J. F. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.049478 · Cited by 5,084
Buck, R. C., Franklin, J., Berger, U., Conder, J. M., Cousins, I. T., de Voogt, P., Jensen, A. A., Kannan, K., Mabury, S. A., & van Leeuwen, S. P. (2011) · Integrated Environmental Assessment and Management · doi:10.1002/ieam.258 · Cited by 4,641
Proliferation, cell cycle and apoptosis in cancer
Evan, G. I., & Vousden, K. H. (2001) · Nature · doi:10.1038/35077213 · Cited by 2,724
Thyroid Hormone Regulation of Metabolism
Mullur, R., Liu, Y.-Y., & Brent, G. A. (2014) · Physiological Reviews · doi:10.1152/physrev.00030.2013 · Cited by 2,421
Animal models of human disease: zebrafish swim into view
Lieschke, G. J., & Currie, P. D. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2091 · Cited by 2,167
A first global production, emission, and environmental inventory for perfluorooctane sulfonate
Paul, A. G., Jones, K. C., & Sweetman, A. J. (2009) · Environmental Science & Technology · doi:10.1021/es802216n · Cited by 1,096
From the genetic architecture to synaptic plasticity in autism spectrum disorder
Bourgeron, T. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3992 · Cited by 975
Lipid Metabolism and Liver Inflammation. II. Fatty liver disease and fatty acid oxidation
Reddy, J. K., & Sambasiva Rao, M. (2006) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00521.2005 · Cited by 860
Citric Acid Cycle and Role of its Intermediates in Metabolism
Akram, M. (2014) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-013-9750-1 · Cited by 741
Cited by
Chemical Aspects of Human and Environmental Overload with Fluorine
Han, J., Kiss, L., Mei, H., Remete, A. M., Ponikvar-Svet, M., Sedgwick, D. M., Roman, R., Fustero, S., Moriwaki, H., & Soloshonok, V. A. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c01263 · Cited by 537
PFAS removal by ion exchange resins: A review
Dixit, F., Dutta, R., Barbeau, B., Berube, P., & Mohseni, M. (2021) · Chemosphere · doi:10.1016/j.chemosphere.2021.129777 · Cited by 438
A review of the emerging treatment technologies for PFAS contaminated soils
Mahinroosta, R., & Senevirathna, L. (2020) · Journal of Environmental Management · doi:10.1016/j.jenvman.2019.109896 · Cited by 352
Yang, L., He, L., Xue, J., Ma, Y., Xie, Z., Wu, L., Huang, M., & Zhang, Z. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.122405 · Cited by 303
PFAS Environmental Pollution and Antioxidant Responses: An Overview of the Impact on Human Field
Bonato, M., Corrà, F., Bellio, M., Guidolin, L., Tallandini, L., Irato, P., & Santovito, G. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17218020 · Cited by 243
Metadata
- Authors
- Zeng, Z., Song, B., Xiao, R., Zeng, G., Gong, J., Chen, M., Xu, P., Zhang, P., Shen, M., & Yi, H.
- Venue
- Environment International
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 126
- Pages
- 598-610
- ISSN
- 0160-4120 (ISSN-L)
- OpenAlex
- W2921969408
- Cited by
- 299
- References
- 132
- FWCI
- 13.87
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Assessing the human health risks of perfluorooctane sulfonate by in vivo and in vitro studies. https://app.cochat.ai/papers/10.1016/j.envint.2019.03.002
- The paper
- Zeng, Z., Song, B., Xiao, R., Zeng, G., Gong, J., Chen, M., Xu, P., Zhang, P., Shen, M., & Yi, H. (2019). Assessing the human health risks of perfluorooctane sulfonate by in vivo and in vitro studies. Environment International. https://doi.org/10.1016/j.envint.2019.03.002
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
