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Cited by 57Toxic Organic Pollutants ImpactEffects and risks of endocrine disrupting chemicalsBirth, Development, and Health

Prenatal exposure to persistent organic pollutants and markers of obesity and cardiometabolic risk in Spanish adolescents

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Güil-Oumrait, Nuria, Valvi, Damaskini, Garcia-Esteban, Raquel, Guxens, Monica, Sunyer, Jordi, Torrent, Maties, Casas, Maribel, Vrijheid, Martine·2021·Environment International
DOI 10.1016/j.envint.2021.106469PMC PMC7960637
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Abstract

BACKGROUND: Prenatal exposure to persistent organic pollutants (POPs) has been linked to cardiometabolic (CM) risk factors in childhood, but there are no studies evaluating the persistence of these associations into adolescence, a period of relevant changes in endocrine-dependent organ systems and rapid increases in lean and fat mass. We examined the associations of prenatal POP exposures with body mass index (BMI) from age 4 to 18 years, and with other CM risk markers in adolescence. METHODS: We analysed 379 children from the Spanish INMA-Menorca birth cohort study with measured cord blood POP concentrations. We calculated BMI z-scores at ages 4, 6, 11, 14 and 18 years using the WHO growth reference. Body fat % was measured at 11 and 18 years and waist-to-height ratio (WHtR) and blood pressure (BP) at 11, 14 and 18 years. We measured CM biomarkers in fasting blood collected at age 14 years and calculated a CM-risk score as the sum of the sex-, and age-specific z-scores for waist circumference, mean arterial BP, homeostatic model assessment of insulin resistance, fasting blood triglycerides, and high-density lipoprotein cholesterol (HDL-C) (n = 217). Generalised estimating equations and multivariate linear regression models assessed the associations with repeated and single time-point measures, respectively. RESULTS: Hexachlorobenzene (HCB) exposure in the third tertile, compared to the first tertile, was associated with higher BMI (β = 0.24; 95% CI: 0.01, 0.47) and WHtR z-score (β = 0.27; 95% CI: 0.04, 0.51). A continuous increase in HCB was associated with an elevated body fat % (β per 10-fold increase = 4.21; 95% CI: 0.51, 7.92), systolic BP (β = 0.32; 95% CI: 0.02, 0.64) and diastolic BP z-score (β = 0.32; 95% CI: 0.02, 0.62) across all ages, and with higher CM-risk score (β = 1.59; 95% CI: 0.02, 3.18) and lipid biomarkers (total cholesterol, triglycerides and low-density lipoprotein cholesterol (LDL-C)) at 14 years. Dichlorodiphenyltrichloroethane (p,p'-DDT) exposure was non-monotonically associated with BMI and systolic BP. p,p'-DDE and Σ-polychlorinated biphenyls (PCBs) (sum of congeners 118, 138, 153, 180) were not associated with adiposity or BP. p,p'-DDT exposure was associated with an increased CM-risk score, and ΣPCBs concentrations with LDL-C in all adolescents and with total cholesterol only in girls (p-sex interaction = 0.05). CONCLUSION: This first longitudinal study from 4 to 18 years suggests that the previously reported POP associations with child BMI persist later in adolescence and that prenatal POP exposures are associated with major risk factors for adult CM syndrome.

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Authors
Güil-Oumrait, N., Valvi, D., Garcia-Esteban, R., Guxens, M., Sunyer, J., Torrent, M., Casas, M., & Vrijheid, M.
Affiliations
  • Universitat Pompeu Fabra (ES)
  • Icahn School of Medicine at Mount Sinai (US)
Corresponding author
Güil-Oumrait, Nuria
ORCID
Venue
Environment International
Publisher
Elsevier BV
Published
2021-06
Volume
151
Pages
106469
ISSN
0160-4120 (ISSN-L)
DOI
10.1016/j.envint.2021.106469
PMC
PMC7960637
OpenAlex
W3133976588
Cited by
57
References
84
Citations by year
2026: 8 · 2025: 10 · 2024: 13 · 2023: 9 · 2022: 10 · 2021: 7
FWCI
3.87
Type
journal article
Language
en
Open access
Licence
Locations
  • Environment International (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, cc-by-nc-nd)
  • Docusalut (Conselleria de Salut i Consum del Govern de les Illes Balears) (submittedVersion, cc-by-nc-nd)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Hispana (submittedVersion, cc-by-nc-nd)
  • Repositori digital de la UPF (Universitat Pompeu Fabra) (submittedVersion, cc-by-nc-nd)
Funders
  • Instituto de Salud Carlos III (INMA G03/176, CB06/02/0041, PI14/00677, 00/0021-2, PS0901958, PI061756, 97/0588)
  • Horizon 2020 (825712)
  • Ministerio de Ciencia, Innovación y Universidades
  • Generalitat de Catalunya
  • European Commission (CP16/00128, QLK4-CT-2000-00263)
  • European Social Fund (CPII18/00018)
  • National Institute of Environmental Health Sciences (R21ES029328, P30ES023515)
  • European Regional Development Fund
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords
persistent organic pollutants, prenatal exposure, hexachlorobenzene, cardiometabolic risk, obesity, body mass index, waist-to-height ratio, body fat percentage, blood pressure, insulin resistance, HDL cholesterol, triglycerides, adolescents, cord blood biomarkers, endocrine disruption, cardiovascular risk markers, Spanish adolescents
MeSH terms
Persistent Organic Pollutants, Adolescent, Adult, Cardiovascular Diseases, Child, Child, Preschool, Environmental Pollutants, Female, Humans, Longitudinal Studies, Obesity, Pregnancy, Prenatal Exposure Delayed Effects, Spain, Cohort Studies, Biomarkers

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