The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
PM2.5 induces ferroptosis in human endothelial cells through iron overload and redox imbalance
Abstract
PM2.5 is becoming a worldwide environmental problem, which profoundly endangers public health, thus progressively capturing public attention this decade. As a fragile target of PM2.5, the underlying mechanisms of endothelial cell damage are still obscure. According to the previous microarray data and signaling pathway analysis, a new form of cell death termed ferroptosis in the current study is proposed following PM2.5 exposure. In order to verify the vital role of ferroptosis in PM2.5-induced endothelial lesion and further understand the potential mechanism involved, intracellular iron content, ROS release and lipid peroxidation, as well as biomarkers of ferroptosis were detected, respectively. As a result, uptake of particles increases cellular iron content and ROS production. Meanwhile, GSH depletion, and the decrease of GSH-Px and NADPH play significant roles in PM2.5-induced endothelial cell ferroptosis. Moreover, significantly changed expression of TFRC, FTL and FTH1 hinted that dysfunction of iron uptake and storage is a major inducer of ferroptosis. Importantly, index monitored above can be partially rescued by lipid peroxidation inhibitor ferrostatin-1 and iron chelator deferoxamine mesylate, which mediated antiferroptosis activity mainly depends on the restoration of antioxidant activity and iron metabolism. In conclusion, our data basically show that PM2.5 enhances ferroptosis sensitivity with increased ferroptotic events in endothelial cells, in which iron overload, lipid peroxidation and redox imbalance act pivotal roles.
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Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
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Ferroptosis as a p53-mediated activity during tumour suppression
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Ferroptosis: Death by Lipid Peroxidation
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NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis
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Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis
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Cited by
Ferroptosis: machinery and regulation
Chen, X., Li, J., Kang, R., Klionsky, D. J., & Tang, D. (2021) · Autophagy · doi:10.1080/15548627.2020.1810918 · Cited by 2,099
SARS-CoV-2 infection, COVID-19 pathogenesis, and exposure to air pollution: What is the connection?
Woodby, B., Arnold, M. M., & Valacchi, G. (2021) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14512 · Cited by 160
Wei, M., Bao, G., Li, S., Yang, Z., Cheng, C., & Le, W. (2022) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2022.114333 · Cited by 55
Ghio, A. J., Soukup, J. M., Dailey, L. A., & Madden, M. C. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.02.007 · Cited by 39
Direct and Indirect Effects of Indoor Particulate Matter on Blood Indicators Related to Anemia
Kwag, Y., Ye, S., Oh, J., Lee, D.-W., Yang, W., Kim, Y., & Ha, E. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182412890 · Cited by 25
Metadata
- Authors
- Wang, Y., & Tang, M.
- Venue
- Environmental Pollution
- Publisher
- Elsevier BV
- Published
- 2019-11
- Volume
- 254
- Issue
- Pt A
- Pages
- 112937
- ISSN
- 0269-7491 (ISSN-L)
- OpenAlex
- W2966421376
- Cited by
- 253
- References
- 46
- FWCI
- 19.44
- Type
- journal article
- Language
- en
- Open access
- closed
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