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Cited by 63Air Quality and Health ImpactsEnvironmental Justice and Health DisparitiesHealth, Environment, Cognitive Aging

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Association between prenatal particulate air pollution exposure and telomere length in cord blood: Effect modification by fetal sex

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Rosa, Maria José, Hsu, Hsiao-Hsien Leon, Just, Allan C., Brennan, Kasey J., Bloomquist, Tessa, Kloog, Itai, Pantic, Ivan, Mercado García, Adriana, Wilson, Ander, Coull, Brent A., Wright, Robert O., Téllez Rojo, Martha María, Baccarelli, Andrea A., Wright, Rosalind J.·2019·Environmental Research
DOI 10.1016/j.envres.2019.03.003PMC PMC6511309
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Abstract

Introduction In utero particulate matter exposure produces oxidative stress that impacts cellular processes that include telomere biology. Newborn telomere length is likely critical to an individual's telomere biology; reduction in this initial telomere setting may signal increased susceptibility to adverse outcomes later in life. We examined associations between prenatal particulate matter with diameter ≤2.5 µm (PM 2.5) and relative leukocyte telomere length (LTL) measured in cord blood using a data-driven approach to characterize sensitive windows of prenatal PM 2.5 effects and explore sex differences. Methods Women who were residents of Mexico City and affiliated with the Mexican Social Security System were recruited during pregnancy (n = 423 for analyses). Mothers' prenatal exposure to PM 2.5 was estimated based on residence during pregnancy using a validated satellite-based spatio-temporally resolved prediction model. Leukocyte DNA was extracted from cord blood obtained at delivery. Duplex quantitative polymerase chain reaction was used to compare the relative amplification of the telomere repeat copy number to single gene (albumin) copy number. A distributed lag model incorporating weekly averages for PM 2.5 over gestation was used in order to explore sensitive windows. Sex-specific associations were examined using Bayesian distributed lag interaction models. Results In models that included child's sex, mother's age at delivery, prenatal environmental tobacco smoke exposure, pre-pregnancy BMI, gestational age, birth season and assay batch, we found significant associations between higher PM 2.5 exposure during early pregnancy (4-9 weeks) and shorter LTL in cord blood. We also identified two more windows at 14-19 and 34-36 weeks in which increased PM 2.5 exposure was associated with longer LTL. In stratified analyses, the mean and cumulative associations between PM 2.5 and shortened LTL were stronger in girls when compared to boys. Conclusions Increased PM 2.5 during specific prenatal windows was associated with shorter LTL and longer LTL. PM 2.5 was more strongly associated with shortened LTL in girls when compared to boys. Understanding sex and temporal differences in response to air pollution may provide unique insight into mechanisms.

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Metadata

Authors
Rosa, M. J., Hsu, H.-H. L., Just, A. C., Brennan, K. J., Bloomquist, T., Kloog, I., Pantic, I., Mercado García, A., Wilson, A., Coull, B. A., Wright, R. O., Téllez Rojo, M. M., Baccarelli, A. A., & Wright, R. J.
Affiliations
  • Icahn School of Medicine at Mount Sinai (US)
  • Columbia University (US)
  • Ben-Gurion University of the Negev (IL)
  • Instituto Nacional de Perinatología (MX)
  • Colorado State University (US)
  • Harvard University (US)
ORCID
Venue
Environmental Research
Publisher
Elsevier BV
Published
2019-05
Volume
172
Pages
495-501
ISSN
0013-9351 (ISSN-L)
DOI
10.1016/j.envres.2019.03.003
PMC
PMC6511309
OpenAlex
W2919943836
Cited by
63
References
5
Citations by year
2026: 3 · 2025: 5 · 2024: 7 · 2023: 6 · 2022: 13 · 2021: 13 · 2020: 10 · 2019: 4
FWCI
4.31
Type
journal article
Language
en
Open access
Licence
Locations
  • Environmental Research (acceptedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
Ministry of Health
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Air Quality and Health Impacts
  • Social Sciences › Sociology and Political Science › Environmental Justice and Health Disparities
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
Keywords
prenatal air pollution exposure, PM2.5, leukocyte telomere length, umbilical cord blood, fetal sex differences, oxidative stress, prenatal exposure, sex-specific effects, Mexico City
MeSH terms
Air Pollutants, Air Pollution, Bayes Theorem, Child, Female, Fetal Blood, Humans, Infant, Newborn, Male, Mexico, Pregnancy, Sex Factors, Telomere, Maternal Exposure, Particulate Matter

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