Degradation products of clavulanic acid promote clavulanic acid production in cultures of Streptomyces clavuligerus
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Lynch and Yang (2004) suggested that L-lysine is one of the most important amino acids for clavulanic acid production, given that fermentation broths with low L-lysine (1 g/L) failed to yield any clavulanic acid.
“The study suggested that L-lysine is one of the most important amino acids for the production of clavulanic acid, given that fermentation broths with low concentrations of L-lysine (1 g/L) failed to yield any clavulanic acid.”
From Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review (2016) · cites this paper as Lynch and Yang (2004)
Addition of arginine or ornithine in fermentation media would increase the flow of C5 precursors into the biosynthesis pathway, which would subsequently increase clavulanic acid production.
“Thus, the addition of arginine or ornithine in fermentation media would increase the flow of C5 precursors into the biosynthesis pathway, which then subsequently increase the production of clavulanic acid (Romero et al., 1986; Lynch and Yang, 2004).”
From Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review (2016) · cites this paper as Lynch and Yang, 2004
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Ser, H.-L., Law, J. W.-F., Chaiyakunapruk, N., Jacob, S. A., Palanisamy, U. D., Chan, K.-G., Goh, B.-H., & Lee, L.-H. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00522 · Cited by 90 · see citing works
“The main difference between batch and fed-batch fermentation systems is that the latter is frequently monitored with the assistance of sophisticated technologies and allows precise control of the entire fermentation process (Longobardi, 1994; Li et al., 2014).”
BackgroundZou, X., & Li, J. (2013) · Annals of Microbiology · doi:10.1007/s13213-012-0597-2 · Cited by 13 · see citing works
- Authors
- Lynch, H. C., & Yang, Y.
- Affiliations
- University of Reading (GB)
- Corresponding author
- Lynch, H.C.
- Venue
- Enzyme and Microbial Technology
- Publisher
- Elsevier BV
- Published
- 2004-01
- Volume
- 34
- Issue
- 1
- Pages
- 48-54
- ISSN
- 0141-0229 (ISSN-L)
- OpenAlex
- W1966376096
- Cited by
- 35
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 1 · 2021: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 5 · 2014: 1 · 2013: 3 · 2012: 4
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Enzyme and Microbial Technology (publishedVersion)
- CentAUR (University of Reading) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Metabolism and Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Enzyme Production and Characterization
- Keywords
- clavulanic acid, Streptomyces clavuligerus, antibiotic degradation, degradation products, biomass accumulation, yield coefficient, antibiotic production, batch culture
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