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Dysregulation of microRNA-128 expression in WHO grades 2 glioma is associated with glioma-associated epilepsy

Yuan, Yang, Xiang, Wang, Yanhui, Liu, Ruofei, Liang, Yunhe, Mao, Jiewen, Luo, Qing, Mao·2016·Epilepsy Research
DOI 10.1016/j.eplepsyres.2016.08.005
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Abstract

Objective Approximately 80% of glioma patients will experience at least one seizure activity during the course of the disease, and because the etiology of glioma-related seizure is most likely multifactorial and complex, it remains poorly understood. MicroRNAs are a class of small noncoding RNAs that function as critical gene regulators. MicroRNA-128 was found to be decreased in glioblastoma, and knockout of the microRNA-128a gene could induce epilepsy in mice. Based on the Chinese Glioma Genome Atlas and previous study, we hypothesized that dysregulation of miR-128 expression may play a role in the pathogenesis of TAE in low-grade glioma. Methods Fifty-three low-grade glioma samples were analyzed for the expression levels of miR-128 using qRT-PCR, and candidate targets of miR-128 (Cacnge2, GRIK3, and GRIN2D) were detected by the 3'-UTR luciferase reporter assay. Four other miRs (miR-9, miR-192a, miR-92a, and miR-451) that showed dysregulation of glioblastoma in the CGGA data were also analyzed. Results The microRNA-128 expression levels were down-regulated in low-grade glioma tissue (t-test; p=0.009). Dysregulation of miR-128 expression in low-grade glioma is associated with glioma-associated epilepsy (p=0.006). No statistical significance of miR-9, miR-192a, miR-92a, and miR-451 was found to be associated with LGG. Conclusion Our results here, together with other recent lines of evidence, indicate that miR-128 is an extremely attractive target for therapy in glioma patients…

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Research works printed but not linked: 23

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Metadata

Authors
Yuan, Y., Xiang, W., Yanhui, L., Ruofei, L., Yunhe, M., Jiewen, L., & Qing, M.
ORCID
Qing, Mao
Venue
Epilepsy Research
Publisher
Elsevier BV
Published
2016-11
Volume
127
Pages
6-11
ISSN
0920-1211
DOI
10.1016/j.eplepsyres.2016.08.005
Cited by
17
References
0
Language
en
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