Preclinical research on stress, memory, and the brain in the development of pharmacotherapy for depression
Abstract
We have reviewed two areas of research on stress, memory, and synaptic plasticity which may be relevant toward understanding the neurobiology of major depressive disorder (MDD). First, we have presented the view that the hippocampus (HC) and prefrontal cortex (PFC) function jointly as a memory system which enables multitask processing (working memory) and consolidation of contextual information. The amygdala, by contrast, is necessary for the consolidation of emotional memories. Cognitive and neurophysiological studies have shown that HC-PFC processing is impaired, and amygdaloid processing is enhanced, by stress and in anxiety and mood disorders, including MDD. Second, we have reviewed research on the behavioral and neurophysiological actions of tianeptine, an antidepressant that is known to block the adverse effects of chronic stress on hippocampal morphology. Recent work has shown that acute tianeptine enhances cognitive and electrophysiological measures of HC-PFC functioning without interfering with the emotion-induced enhancement of amygdaloid functioning in rodents. We conclude with a synthesis of the preclinical and clinical literature on stress, memory, and tianeptine with the proposal that tianeptine should enhance HC-PFC memory-related processing in people under stress.
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30 minutes of cat exposure impaired spatial memory.
“we have shown that 30 minutes of cat exposure not only impaired spatial memory (Kim and Diamond [1]; Diamond et al. [10]; Diamond et al. [2]; Diamond et al. [3])”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Diamond et al. [10]
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The stressed hippocampus, synaptic plasticity and lost memories
Kim, J. J., & Diamond, D. M. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn849 · Cited by 1,543 · see citing works
Self-citationFear conditioning induces associative long-term potentiation in the amygdala
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Exposing Rats to a Predator Blocks Primed Burst Potentiation in the Hippocampus<i>In Vitro</i>
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Diamond, D. M., Campbell, A. M., Park, C. R., Halonen, J., & Zoladz, P. R. (2007) · Neural Plasticity · doi:10.1155/2007/60803 · Cited by 762 · see citing works
“First, we have shown that 30 minutes of cat exposure not only impaired spatial memory (Kim and Dia-mond [1]; Diamond et al. [10]; Diamond et al. [2]; Diamond et al. [3]), it also suppressed molecular (Sandi et al. [136]) and structural (Diamond et al. [137]) measures of plasticity in the…”
BackgroundSelf-citationMcEwen, B. S., Chattarji, S., Diamond, D. M., Jay, T. M., Reagan, L. P., Svenningsson, P., & Fuchs, E. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.80 · Cited by 406 · see citing works
Self-citationHow can drug discovery for psychiatric disorders be improved?
Agid, Y., Buzsáki, G., Diamond, D. M., Frackowiak, R., Giedd, J., Girault, J.-A., Grace, A., Lambert, J. J., Manji, H., Mayberg, H., et al. (2007) · Nature Reviews Drug Discovery · doi:10.1038/nrd2217 · Cited by 240 · see citing works
Self-citationCui, M., Yang, Y., Yang, J., Zhang, J., Han, H., Ma, W., Li, H., Mao, R., Xu, L., Hao, W., et al. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2006.05.048 · Cited by 153 · see citing works
Vouimba, R.-M., Muñoz, C., & Diamond, D. M. (2006) · Stress · doi:10.1080/10253890600610973 · Cited by 96 · see citing works
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- Authors
- Diamond, D. M., Campbell, A., Park, C. R., & Vouimba, R.-M.
- Affiliations
- University of South Florida (US)
- Corresponding author
- Diamond, David M.
- Venue
- European Neuropsychopharmacology
- Publisher
- Elsevier BV
- Published
- 2004-12
- Volume
- 14
- Pages
- S491-S495
- ISSN
- 0924-977X (ISSN-L)
- OpenAlex
- W2008049551
- Cited by
- 71
- References
- 8
- Citations by year
- 2026: 2 · 2020: 3 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 5 · 2013: 4 · 2012: 4
- FWCI
- 4.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Digital Commons - University of South Florida (University of South Florida) (submittedVersion)
- Funders
- Servier
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- major depressive disorder, chronic stress, memory consolidation, hippocampus, prefrontal cortex, amygdala, emotional memory, synaptic plasticity, tianeptine, antidepressants, hippocampal morphology, working memory, stress-induced memory impairment
- MeSH terms
- Antidepressive Agents, Antidepressive Agents, Tricyclic, Brain, Depressive Disorder, Humans, Memory, Stress, Physiological, Thiazepines, Long-Term Potentiation
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