Cited by 406Treatment of Major DepressionNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

The neurobiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation

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McEwen, B S, Chattarji, S, Diamond, D M, Jay, T M, Reagan, L P, Svenningsson, P, Fuchs, E·2010·Molecular Psychiatry

Abstract

Tianeptine is a clinically used antidepressant that has drawn much attention, because this compound challenges traditional monoaminergic hypotheses of depression. It is now acknowledged that the antidepressant actions of tianeptine, together with its remarkable clinical tolerance, can be attributed to its particular neurobiological properties. The involvement of glutamate in the mechanism of action of the antidepressant tianeptine is consistent with a well-developed preclinical literature demonstrating the key function of glutamate in the mechanism of altered neuroplasticity that underlies the symptoms of depression. This article reviews the latest evidence on tianeptine's mechanism of action with a focus on the glutamatergic system, which could provide a key pathway for its antidepressant action. Converging lines of evidences demonstrate actions of tianeptine on the glutamatergic system, and therefore offer new insights into how tianeptine may be useful in the treatment of depressive disorders.

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Crossref · 10.1038/mp.2009.80

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  • Sertraline's effect suggests that fluoxetine influences the human visual cortex.

    “indicating that fluoxetine influences human visual cortex.”
  • A 3-week sertraline treatment increases visually evoked potentials in healthy humans in response to strong visual stimulation.

    “Normann and colleagues showed that a 3-week treatment with the antidepressant sertraline increases visually evoked potentials in response to a strong visual stimulation in healthy humans202”

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  1. [113]Lowy MT Wittenberg L Yamamoto BK Effect of acute stress on hippocampal glutamate levels and spectrin proteolysis in young and aged rats J Neurochem 1995 65 268 274 7790870

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Authors
McEwen, B. S., Chattarji, S., Diamond, D. M., Jay, T. M., Reagan, L. P., Svenningsson, P., & Fuchs, E.
Affiliations
  • Rockefeller University (US)
  • National Centre for Biological Sciences (IN)
  • United States Department of Veterans Affairs (US)
  • Inserm (FR)
  • University of South Carolina (US)
  • Karolinska Institutet (SE)
  • German Primate Center (DE)
Corresponding author
McEwen, B S
Venue
Molecular Psychiatry
Published
2009-08-25
Volume
15
Issue
3
Pages
237-249
ISSN
  • 1359-4184 (ISSN-L)
  • 1476-5578
OpenAlex
W2068677212
Cited by
406
References
123
Citations by year
2026: 5 · 2025: 15 · 2024: 7 · 2023: 12 · 2022: 8 · 2021: 15 · 2020: 168 · 2019: 12 · 2018: 17 · 2017: 13 · 2016: 19 · 2015: 19 · 2014: 21 · 2013: 22 · 2012: 25
FWCI
12.74
Type
journal article
Language
en
Open access
Locations
  • Molecular Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Digital Commons - University of South Florida (University of South Florida) (submittedVersion)
  • GRO (submittedVersion)
Funders
National Institute of Mental Health (R01MH041256)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
tianeptine, antidepressant mechanism, glutamatergic system, glutamate, neuroplasticity, depression
MeSH terms
Animals, Antidepressive Agents, Tricyclic, Anxiety, Brain, Cognition Disorders, Depression, Disease Models, Animal, Humans, Neuronal Plasticity, Stress, Psychological, Thiazepines, Anti-Anxiety Agents, Biogenic Monoamines, Glutamic Acid

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