The neurobiological properties of tianeptine (Stablon): from monoamine hypothesis to glutamatergic modulation
Open accessAbstract
Tianeptine is a clinically used antidepressant that has drawn much attention, because this compound challenges traditional monoaminergic hypotheses of depression. It is now acknowledged that the antidepressant actions of tianeptine, together with its remarkable clinical tolerance, can be attributed to its particular neurobiological properties. The involvement of glutamate in the mechanism of action of the antidepressant tianeptine is consistent with a well-developed preclinical literature demonstrating the key function of glutamate in the mechanism of altered neuroplasticity that underlies the symptoms of depression. This article reviews the latest evidence on tianeptine's mechanism of action with a focus on the glutamatergic system, which could provide a key pathway for its antidepressant action. Converging lines of evidences demonstrate actions of tianeptine on the glutamatergic system, and therefore offer new insights into how tianeptine may be useful in the treatment of depressive disorders.
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- Authors
- McEwen, B. S., Chattarji, S., Diamond, D. M., Jay, T. M., Reagan, L. P., Svenningsson, P., & Fuchs, E.
- Affiliations
- Rockefeller University (US)
- National Centre for Biological Sciences (IN)
- United States Department of Veterans Affairs (US)
- Inserm (FR)
- University of South Carolina (US)
- Karolinska Institutet (SE)
- German Primate Center (DE)
- Corresponding author
- McEwen, B S
- Venue
- Molecular Psychiatry
- Published
- 2009-08-25
- Volume
- 15
- Issue
- 3
- Pages
- 237-249
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- PMC
- PMC2902200
- OpenAlex
- W2068677212
- Cited by
- 406
- References
- 123
- Citations by year
- 2026: 5 · 2025: 15 · 2024: 7 · 2023: 12 · 2022: 8 · 2021: 15 · 2020: 168 · 2019: 12 · 2018: 17 · 2017: 13 · 2016: 19 · 2015: 19 · 2014: 21 · 2013: 22 · 2012: 25
- FWCI
- 12.74
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Molecular Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Digital Commons - University of South Florida (University of South Florida) (submittedVersion)
- GRO (submittedVersion)
- Funders
- National Institute of Mental Health (R01MH041256)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- tianeptine, antidepressant mechanism, glutamatergic system, glutamate, neuroplasticity, depression
- MeSH terms
- Animals, Antidepressive Agents, Tricyclic, Anxiety, Brain, Cognition Disorders, Depression, Disease Models, Animal, Humans, Neuronal Plasticity, Stress, Psychological, Thiazepines, Anti-Anxiety Agents, Biogenic Monoamines, Glutamic Acid
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