A smart drug delivery system responsive to pH/enzyme stimuli based on hydrophobic modified sodium alginate
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Drug release studies can be used as a proof-of-concept of the stimuli-responsiveness of micellar systems.
“Drug release studies can also be used as a proof-of-concept of the stimuli-responsiveness of the micellar systems.”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [130]
Stimuli that change micelles structure and trigger drug release include pH, reducing agents such as glutathione, specific enzymes such as matrix metalloproteinases, and external stimuli such as ultrasounds, temperature, and light.
“Stimuli that change micelles structure and trigger drug release are for instance pH (typically lower in endosomes/lysosomes, in tumor cells and in inflamed tissues), presence of reducing agents (such as glutathione, whose level is quite elevated in some tumors), specific enzymes (for instance matrix metalloproteinases overexpressed at tumor sites or matrix metalloproteinases-13, overexpressed in o”
From Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions (2021) · cites this paper as [130]
Cited by
Sorted by citations
Ghezzi, M., Pescina, S., Padula, C., Santi, P., Del Favero, E., Cantù, L., & Nicoli, S. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.02.031 · Cited by 1,135 · see citing works
Zhang, W., Taheri-Ledari, R., Ganjali, F., Afruzi, F. H., Hajizadeh, Z., Saeidirad, M., Qazi, F. S., Kashtiaray, A., Sehat, S. S., Hamblin, M. R., et al. (2022) · Heliyon · doi:10.1016/j.heliyon.2022.e09577 · Cited by 79 · see citing works
Retracted
- Authors
- Gao, X., Yu, Z., Liu, B., Yang, J., Yang, X., & Yu, Y.
- Affiliations
- Qingdao University of Science and Technology (CN)
- Corresponding author
- Yang, Xiaoyan
- Yu, Yueqin
- Venue
- European Polymer Journal
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 133
- Pages
- 109779
- ISSN
- 0014-3057 (ISSN-L)
- OpenAlex
- W3026860585
- Cited by
- 53
- References
- 0
- Citations by year
- 2026: 1 · 2025: 10 · 2024: 11 · 2023: 11 · 2022: 8 · 2021: 10 · 2020: 2
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Polymer Journal (publishedVersion)
- Funders
- Natural Science Foundation of Shandong Province of China (ZR2019MB051)
- Shandong Provincial Key Research and Development Program (2018GGX102001)
- Foundation of Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science
- Qingdao University of Science and Technology (SATM201701)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- pH-responsive drug delivery, enzyme-responsive drug delivery, dual-responsive drug delivery, polymeric micelles, self-assembly, doxorubicin, drug loading efficiency, pH-responsive drug release, alpha-L-fucosidase, tumor cell uptake, biocompatible drug carriers
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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