Cited by 81Nanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsDendrimers and Hyperbranched Polymers

RETRACTED: Nanoscale bioconjugates: A review of the structural attributes of drug-loaded nanocarrier conjugates for selective cancer therapy

Open access
Zhang, Wenjie, Taheri-Ledari, Reza, Ganjali, Fatemeh, Afruzi, Fereshte Hassanzadeh, Hajizadeh, Zoleikha, Saeidirad, Mahdi, Qazi, Fateme Sadat, Kashtiaray, Amir +3 more·2022·Heliyon

Abstract

Nanobioconjugates are nanoscale drug delivery vehicles that have been conjugated to or decorated with biologically active targeting ligands. These targeting ligands can be antibodies, peptides, aptamers, or small molecules such as vitamins or hormones. Most research studies in this field have been devoted to targeting cancer. Moreover, the nanostructures can be designed with an additional level of targeting by being designed to be stimulus-responsive or "smart" by a judicious choice of materials to be incorporated into the hybrid nanostructures. This stimulus could be an acidic pH, raised temperature, enzyme, ultrasound, redox potential, an externally applied magnetic field, or laser irradiation. In this case, the smart capability can increase the accumulation at the tumor site or the on-demand drug release, while the ligand ensures selective binding to the tumor cells. The present review highlights some interesting studies classified according to the nanostructure material. These materials include natural substances (polysaccharides), multi-walled carbon nanotubes (and halloysite nanotubes), metal-organic frameworks and covalent-organic frameworks, metal nanoparticles (gold and silver), and polymeric micelles.

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Crossref · 10.1016/j.heliyon.2022.e09577This paper is marked retracted.

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Authors
Zhang, W., Taheri-Ledari, R., Ganjali, F., Afruzi, F. H., Hajizadeh, Z., Saeidirad, M., Qazi, F. S., Kashtiaray, A., Sehat, S. S., Hamblin, M. R., & Maleki, A.
Affiliations
  • Sichuan University (CN)
  • Iran University of Science and Technology (IR)
  • University of Johannesburg (ZA)
Corresponding author
Maleki, Ali
Venue
Heliyon
Publisher
Elsevier BV
Published
2022-06
Volume
8
Issue
6
Pages
e09577
ISSN
2405-8440 (ISSN-L)
OpenAlex
W4281625127
Cited by
79
References
234
Citations by year
2026: 8 · 2025: 17 · 2024: 22 · 2023: 21 · 2022: 11
FWCI
1.22
Type
journal article
Language
en
Status
Retracted
Open access
Locations
  • Heliyon (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Sichuan Province Science and Technology Support Program (2022YFH0047)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
  • Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
Keywords
nanobioconjugates, targeted drug delivery, cancer therapy, targeting ligands, tumor accumulation, on-demand drug release, polysaccharide nanoparticles, multi-walled carbon nanotubes, halloysite nanotubes, metal-organic frameworks, covalent organic frameworks, gold nanoparticles, silver nanoparticles, polymeric micelles, retracted article

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