RETRACTED: Nanoscale bioconjugates: A review of the structural attributes of drug-loaded nanocarrier conjugates for selective cancer therapy
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Nanobioconjugates are nanoscale drug delivery vehicles that have been conjugated to or decorated with biologically active targeting ligands. These targeting ligands can be antibodies, peptides, aptamers, or small molecules such as vitamins or hormones. Most research studies in this field have been devoted to targeting cancer. Moreover, the nanostructures can be designed with an additional level of targeting by being designed to be stimulus-responsive or "smart" by a judicious choice of materials to be incorporated into the hybrid nanostructures. This stimulus could be an acidic pH, raised temperature, enzyme, ultrasound, redox potential, an externally applied magnetic field, or laser irradiation. In this case, the smart capability can increase the accumulation at the tumor site or the on-demand drug release, while the ligand ensures selective binding to the tumor cells. The present review highlights some interesting studies classified according to the nanostructure material. These materials include natural substances (polysaccharides), multi-walled carbon nanotubes (and halloysite nanotubes), metal-organic frameworks and covalent-organic frameworks, metal nanoparticles (gold and silver), and polymeric micelles.
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Gold nanoparticles have become a leading candidate for multiple medical applications owing to their biocompatibility and FDA approval.
“Owing to their biocompatibility and Food and Drug Administration (FDA) approval, AuNPs have become a leading candidate for multiple medical applications.”
From Targeted Nanoparticles for Drug Delivery Across the Blood–Brain Barrier in Early and Late Stages of Alzheimer's Disease: A Review (2026) · cites this paper as [86]
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Nanotherapeutics for Colorectal Cancers Using Nanobiomaterials
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Cutaneous Lymphoma and Antibody-Directed Therapies
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- Authors
- Zhang, W., Taheri-Ledari, R., Ganjali, F., Afruzi, F. H., Hajizadeh, Z., Saeidirad, M., Qazi, F. S., Kashtiaray, A., Sehat, S. S., Hamblin, M. R., & Maleki, A.
- Affiliations
- Sichuan University (CN)
- Iran University of Science and Technology (IR)
- University of Johannesburg (ZA)
- Corresponding author
- Maleki, Ali
- ORCID
- Venue
- Heliyon
- Publisher
- Elsevier BV
- Published
- 2022-06
- Volume
- 8
- Issue
- 6
- Pages
- e09577
- ISSN
- 2405-8440 (ISSN-L)
- PMC
- PMC9189039
- OpenAlex
- W4281625127
- Cited by
- 79
- References
- 234
- Citations by year
- 2026: 8 · 2025: 17 · 2024: 22 · 2023: 21 · 2022: 11
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Status
- Retracted
- Update notices
- Open access
- gold
- doi.org
- Licence
- Locations
- Heliyon (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Sichuan Province Science and Technology Support Program (2022YFH0047)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Keywords
- nanobioconjugates, targeted drug delivery, cancer therapy, targeting ligands, tumor accumulation, on-demand drug release, polysaccharide nanoparticles, multi-walled carbon nanotubes, halloysite nanotubes, metal-organic frameworks, covalent organic frameworks, gold nanoparticles, silver nanoparticles, polymeric micelles, retracted article
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