The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
The association between anxiety and C-reactive protein (CRP) levels: Results from the Northern Finland 1966 Birth Cohort Study
Abstract
BACKGROUND: Anxiety frequently accompanies low-grade inflammation-associated conditions like depression, insulin resistance, coronary heart disease and metabolic syndrome. The association between anxiety and low-grade inflammation is, unlike between depression and low-grade inflammation, a very sparsely studied area in general populations. The aim of the present study was to investigate whether anxiety symptoms as well as comorbid anxiety and depressive symptoms are associated with low-grade inflammation at population level. METHODS: The general population-based Northern Finland 1966 Birth Cohort was followed until age 31 (n=2688 males and 2837 females), when the highly sensitive CRP concentrations were measured. Anxiety and depressive symptoms were defined by Hopkins Symptom Checklist-25 (HSCL-25). RESULTS: After adjusting for confounders, logistic regression analyses showed that anxiety symptoms alone increased the probability for elevated hs-CRP levels (>3.0mg/L) in males over two-fold (2.19 CI 95% 1.08-4.46), while comorbid anxiety and depressive symptoms caused a 1.7-fold (1.76 CI 95% 1.13-2.74) increase in the probability for elevated hs-CRP levels (1.0-3.0mg/L). CONCLUSIONS: Our results support the hypothesis that anxiety as well as comorbid anxiety and depression can be associated with an increased risk for low-grade inflammation in males at population level.
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“Obese individuals exhibiting elevated inflammation, particularly increases in CRP, are more likely to meet criteria for metabolic syndrome and to develop MDD and anxiety [65].”
From The menace of obesity to depression and anxiety prevalence (2022) · cites this paper as [65]
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Cites
Pearson, T. A., Mensah, G. A., Alexander, R. W., Anderson, J. L., Cannon, R. O., Criqui, M., Fadl, Y. Y., Fortmann, S. P., Hong, Y., Myers, G. L., et al. (2003) · Circulation · doi:10.1161/01.cir.0000052939.59093.45 · Cited by 6,401
C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus
Pradhan, A. D. (2001) · JAMA · doi:10.1001/jama.286.3.327 · Cited by 4,433
SCL-90: an outpatient psychiatric rating scale--preliminary report.
Derogatis, L. R., Lipman, R. S., & Covi, L. (1973) · PubMed · Cited by 3,800
Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis.
Howren, M. B., Lamkin, D. M., & Suls, J. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181907c1b · Cited by 2,766
Chronic Subclinical Inflammation as Part of the Insulin Resistance Syndrome
Festa, A., D’Agostino, R., Howard, G., Mykkänen, L., Tracy, R. P., & Haffner, S. M. (2000) · Circulation · doi:10.1161/01.cir.102.1.42 · Cited by 2,366
The HPA axis in major depression: classical theories and new developments
Pariante, C. M., & Lightman, S. L. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.06.006 · Cited by 2,009
Köenig, W., Sund, M., Fröhlich, M., Fischer, H.-G., Löwel, H., Döring, A., Hutchinson, W. L., & Pepys, M. B. (1999) · Circulation · doi:10.1161/01.cir.99.2.237 · Cited by 1,952
Physical Activity and Mental Health: Current Concepts
Paluska, S. A., & Schwenk, T. L. (2000) · Sports Medicine · doi:10.2165/00007256-200029030-00003 · Cited by 1,722
Cytokine-Associated Emotional and Cognitive Disturbances in Humans
Reichenberg, A., Yirmiya, R., Schuld, A., Kraus, T., Haack, M., Morag, A., & Pollmächer, T. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.5.445 · Cited by 1,365
Katon, W. J. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00273-7 · Cited by 1,248
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Kheirabadi, G., Bagherian-Sararoudi, R., Kousha, M., Toghani, F., Hashemi, M., & Maracy, M. R. (2014) · Advanced Biomedical Research · doi:10.4103/2277-9175.143254 · Cited by 4
“(4) Finally, the possibility of publishing bias should not be far from the minds, as some studies showed the association of psychological factors such as anxiety/depression,[43-48] and others showed no association between mood disorders and systemic inflammation or endothelial dysfunction.”
Retinal changes in generalized anxiety disorder patients
Baykara, S., Kılıçaslan, A. K., Yıldırım, H., Tabara, M. F., Kaşıkçı, H. Ö., & Keleş, D. D. (2023) · The International Journal of Psychiatry in Medicine · doi:10.1177/00912174231209771 · Cited by 4
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Armbruster, M., & Forsythe, P. (2025) · NeuroImmunoModulation · doi:10.1159/000543691 · Cited by 6
Hagen, J. M., Sutterland, A. L., Schirmbeck, F. N., Cohn, D. M., Lok, A., Tan, H. L., Zwinderman, A. H., & de Haan, L. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.07.108 · Cited by 3
Knuutila, J., Lahti, S. M., Sipilä, K., & Tolvanen, M. (2023) · Acta Odontologica Scandinavica · doi:10.1080/00016357.2023.2236229 · Cited by 2
Inflammation, Atherosclerosis, and Psychological Factors
Suarez, E. C. (2022) · Springer eBooks · doi:10.1007/978-0-387-85960-6_35 · Cited by 2
Beal, S. J., Hillman, J. B., Dorn, L. D., Out, D., & Pabst, S. R. (2014) · Children s Health Care · doi:10.1080/02739615.2013.876537 · Cited by 2
“In adults, anxiety symptoms and comorbid anxiety and depressive symptoms were associated with an increased probability for elevated CRP (Liukkonen et al., 2011).”
BackgroundLin, C.-C., Chen, C., Chen, C.-L., & Huang, T. (2013) · Transplantation Proceedings · doi:10.1016/j.transproceed.2013.03.023 · Cited by 2
Jiang, C., Zheng, Z., Su, Y. X., Fu, W., & Zhong, Q. (2025) · European journal of medical research · doi:10.1186/s40001-025-03555-7 · Cited by 1
“Elevated CRP levels—reflecting systemic inflammation—have been associated with anxiety disorders in population-based studies [10, 31].”
Evidence Linking Mental Health with Obesity and Metabolic Syndrome: The Role of Inflammation
Morris, A. A., & Vaccarino, V. (2013) · Current Nutrition Reports · doi:10.1007/s13668-013-0054-2 · Cited by 1
Duygudurum ve Anksiyete Bozukluklarında Psikonöroimmünolojik Süreçler ve Psikoterapi ile İlişkisi
Yilmaz, C., & İkizer, G. (2022) · Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry · doi:10.18863/pgy.943148 · Cited by 2
Retinal Changes in Panic Disorder Patients
Baykara, S., Yıldırım, H., Kılıçaslan, A. K., Tabara, M. F., Keleş, D. D., Gürok, M. G., & Atmaca, M. (2022) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2022.111496 · Cited by 3
Entropy and the Lymphatic System, a New Model with Therapeutic Potential
Houck, P. D. (2025) · Global Journal of Medical Research · doi:10.34257/gjmrbvol25is1pg27 · Cited by 2
Bidirectional Association Between COVID-19 and Mental Health Disorders: A Narrative Review
Talaie, H., Hosseini, S. M., Nazari, M., & Nazemi, F. (2021) · International Journal of Medical Toxicology and Forensic Medicine · doi:10.32598/ijmtfm.v11i3.34104 · Cited by 1
Neurobiology of psychiatric disorders
Maletic, V., & DeMuri-Maletic, B. (2017) · Oxford University Press eBooks · doi:10.1093/med/9780198746638.003.0005 · Cited by 1
Anderson, S. T. (2014) · Maynooth University ePrints and eTheses Archive (Maynooth University)
A NON-TARGETED METABOLOMICS APPROACH TO CANINE ANXIETY
Puurunen, J. (2015) · UEF eRepo (University of Eastern Finland)
Hiles, S. A. (2014) · NOVA (University of Newcastle Australia)
Zhang, L., Ran, Y., Wu, M., & Wang, L. (2009) · PubMed
Olisah, V., Abiola, T., Okpataku, C., Obiako, R., Audu, I., & Yakasai, B. (2019) · Nigerian Medical Journal · doi:10.4103/nmj.nmj_74_19
Domagała, P., & Gaworska‐Krzemińska, A. (2020) · Research Square · doi:10.21203/rs.3.rs-46974/v1
Does State Anxiety Affect the Outcome of an Oral Glucose Tolerance Test?
Gezer, E., Demirhan, Y., Selek, A., Cantürk, Z., ÇETİNASLAN, B., Sözen, M., & Karatoprak, A. P. (2021) · Medical Journal of Western Black Sea · doi:10.29058/mjwbs.931394
C reactive protein, a possible biomarker for the major depressive episode
Purnichi, T., Marinescu, I. P., Pîrlog, M. C., Paraschiv, G., Banu, R., DUICA, L. C., Manea, M. C., Bran, M., Grigoras, R. M., & Matei, V. P. (2017) · Romanian Journal of Psychiatry & Psychotherapy · doi:10.37897/rjpp.2017.1.5
Eren, F., & Duksal, F. (2023) · Genel Tıp Dergisi · doi:10.54005/geneltip.1308110
Houck, P. D. (2024) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2024.07.025
Differential associations of depression and anxiety with stress-related biomarkers
Fitzgerald, P. B., Fan, Y. A., Behar, E., & Gunthert, K. C. (2026) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2026.107958
“Studies linking inflammatory markers to anxiety, however, are fewer and more equivocal (Costello et al., 2019; Glaus et al., 2018; Liukkonen et al., 2011).”
Metadata
- Authors
- Liukkonen, T., Räsänen, P., Jokelainen, J., Leinonen, M., Järvelin, M.-R., Meyer-Rochow, V. B., & Timonen, M.
- Affiliations
- Savonlinna Central Hospital (FI)
- University of Oulu (FI)
- Oulu University Hospital (FI)
- Finnish Institute for Health and Welfare (FI)
- Imperial College London (GB)
- Corresponding author
- Liukkonen, T.
- Venue
- European Psychiatry
- Publisher
- Cambridge University Press (CUP)
- Published
- 2011-09
- Volume
- 26
- Issue
- 6
- Pages
- 363-369
- ISSN
- 0924-9338 (ISSN-L)
- 1778-3585
- OpenAlex
- W2057674272
- Cited by
- 127
- References
- 80
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 6 · 2023: 13 · 2022: 12 · 2021: 10 · 2020: 14 · 2019: 7 · 2018: 12 · 2017: 14 · 2016: 7 · 2015: 7 · 2014: 5 · 2013: 8 · 2012: 5
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
- Funders
- Suomen Kulttuurirahasto
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- anxiety, C-reactive protein, low-grade inflammation, depressive symptoms, comorbid depression and anxiety, Hopkins Symptom Checklist-25, Northern Finland Birth Cohort 1966, sex differences, young adults
- MeSH terms
- Adult, Anxiety, Anxiety Disorders, C-Reactive Protein, Depression, Depressive Disorder, Female, Finland, Humans, Male, Surveys and Questionnaires, Comorbidity, Prevalence
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