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Cited by 268Hormonal and reproductive studiesSexual function and dysfunction studiesUrological Disorders and Treatments

The DOI matches its Crossref record; 182 of the 184 references it cites were found in a registry or an index.

Testosterone and Erectile Function: From Basic Research to a New Clinical Paradigm for Managing Men with Androgen Insufficiency and Erectile Dysfunction

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Traish, Abdulmaged M., Goldstein, Irwin, Kim, Noel N.·2007·European Urology
DOI 10.1016/j.eururo.2007.02.034PMC PMC2562639
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Abstract

Objectives Androgens are essential for the development and growth of the penis, and they regulate erectile physiology by multiple mechanisms. Our goal is to provide a concise overview of the basic research and how this knowledge can be translated into a new clinical paradigm for patient management. In addition, this new paradigm may serve as a basis for stimulating constructive debate regarding the use of testosterone in men, and to promote new, innovative basic and clinical research to further understand the underlying mechanisms of androgen action in restoring erectile physiology.Methods A literature review was performed utilizing the US National Library of Medicine's PubMed database.Results On the basis of evidence derived from laboratory animal studies and clinical data, we postulate that androgen insufficiency disrupts cellular-signaling pathways and produces pathologic alterations in penile tissues, leading to erectile dysfunction. In this review, we discuss androgen-dependent cellular, molecular, and physiologic mechanisms modulating erectile function in the animal model, and the implication of this knowledge in testosterone use in the clinical setting to treat erectile dysfunction. The new clinical paradigm incorporates many of the consensed points of view discussed in traditional consensed algorithms exclusively designed for men with androgen insufficiency. There are, however, novel and innovative differences with this new clinical paradigm. This paradigm represents a fresh effort to provide mandatory and optional management strategies for men with both androgen insufficiency and erectile dysfunction.Conclusions The new clinical paradigm is evidence-based and represents one of the first attempts to address a logical management plan for men with concomitant hormonal and sexual health concerns.

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Metadata

Authors
Traish, A. M., Goldstein, I., & Kim, N. N.
Affiliations
Boston University (US)
Corresponding author
Traish, Abdulmaged M.
ORCID
Venue
European Urology
Publisher
Elsevier BV
Published
2007-07
Volume
52
Issue
1
Pages
54-70
ISSN
0302-2838 (ISSN-L)
DOI
10.1016/j.eururo.2007.02.034
PMC
PMC2562639
OpenAlex
W2074489144
Cited by
268
References
184
Citations by year
2026: 6 · 2025: 9 · 2024: 6 · 2023: 12 · 2022: 16 · 2021: 16 · 2020: 10 · 2019: 11 · 2018: 10 · 2017: 9 · 2016: 28 · 2015: 12 · 2014: 11 · 2013: 14 · 2012: 9
FWCI
3.11
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • European Urology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Diabetes and Digestive and Kidney Diseases (DK 56846, DK02696, K01DK002696, R01DK056846)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Health Sciences › Medicine › Urology › Urological Disorders and Treatments
Keywords
testosterone, erectile dysfunction, androgen deficiency, erectile physiology, penile tissue, testosterone replacement therapy, male sexual health
MeSH terms
Androgens, Animals, Humans, Hypogonadism, Erectile Dysfunction, Male, Penile Erection, Testosterone

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