Cited by 268Hormonal and reproductive studiesSexual function and dysfunction studiesUrological Disorders and Treatments

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Testosterone and Erectile Function: From Basic Research to a New Clinical Paradigm for Managing Men with Androgen Insufficiency and Erectile Dysfunction

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Traish, Abdulmaged M., Goldstein, Irwin, Kim, Noel N.·2007·European Urology

DOI 10.1016/j.eururo.2007.02.034PMC PMC2562639

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Abstract

Objectives Androgens are essential for the development and growth of the penis, and they regulate erectile physiology by multiple mechanisms. Our goal is to provide a concise overview of the basic research and how this knowledge can be translated into a new clinical paradigm for patient management. In addition, this new paradigm may serve as a basis for stimulating constructive debate regarding the use of testosterone in men, and to promote new, innovative basic and clinical research to further understand the underlying mechanisms of androgen action in restoring erectile physiology.Methods A literature review was performed utilizing the US National Library of Medicine's PubMed database.Results On the basis of evidence derived from laboratory animal studies and clinical data, we postulate that androgen insufficiency disrupts cellular-signaling pathways and produces pathologic alterations in penile tissues, leading to erectile dysfunction. In this review, we discuss androgen-dependent cellular, molecular, and physiologic mechanisms modulating erectile function in the animal model, and the implication of this knowledge in testosterone use in the clinical setting to treat erectile dysfunction. The new clinical paradigm incorporates many of the consensed points of view discussed in traditional consensed algorithms exclusively designed for men with androgen insufficiency. There are, however, novel and innovative differences with this new clinical paradigm. This paradigm represents a fresh effort to provide mandatory and optional management strategies for men with both androgen insufficiency and erectile dysfunction.Conclusions The new clinical paradigm is evidence-based and represents one of the first attempts to address a logical management plan for men with concomitant hormonal and sexual health concerns.

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A Critical Evaluation of Simple Methods for the Estimation of Free Testosterone in Serum
Vermeulen, A., Verdonck, L., & Kaufman, J. M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.6079 · Cited by 3,824
Mechanisms of fatty acid-induced inhibition of glucose uptake.
Boden, G., Chen, X., Ruiz, J., White, J. V., & Rossetti, L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117252 · Cited by 3,720
Impotence
(1993) · JAMA · doi:10.1001/jama.1993.03510010089036 · Cited by 1,629
C/EBPα induces adipogenesis through PPARγ: a unified pathwayPreprint
Rosen, E. D., Hsu, C.-H., Wang, X., Sakai, S., Freeman, M. W., Gonzalez, F. J., & Spiegelman, B. M. (2002) · Genes & Development · doi:10.1101/gad.948702 · Cited by 1,497
PPARγ: a Nuclear Regulator of Metabolism, Differentiation, and Cell Growth
Rosen, E. D., & Spiegelman, B. M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r100034200 · Cited by 1,178
Untitled work
(1992) · doi:10.1126/science.1378650 · Cited by 1,163
Summary of the Recommendations on Sexual Dysfunctions in Men
Montorsi, F., Adaikan, G. P., Becher, E. F., Giuliano, F., Khoury, S., Lue, T. F., Sharlip, I. D., Althof, S. E., Andersson, K., Brock, G. B., et al. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.02062.x · Cited by 937
Self-citation
Investigation, treatment and monitoring of late-onset hypogonadism in males
Wang, C., Nieschlag, E., Swerdloff, R., Behre, H. M., Hellstrom, W. J., Gooren, L. J., Kaufman, J. M., Legros, J.-J., Lunenfeld, B., Morales, A., et al. (2008) · European Journal of Endocrinology · doi:10.1530/eje-08-0601 · Cited by 867
NIH Consensus Conference. Impotence. NIH Consensus Development Panel on Impotence
(1993) · JAMA · doi:10.1001/jama.270.1.83 · Cited by 843
Loss of Circadian Rhythmicity in Blood Testosterone Levels with Aging in Normal Men*
Bremner, W. J., Vitiello, M. V., & Prinz, P. N. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-56-6-1278 · Cited by 785
Risks of testosterone-replacement therapy and recommendations for monitoring.
Rhoden, E. L., & Morgentaler, A. (2004) · New England Journal of Medicine · doi:10.1056/nejmra022251 · Cited by 705
Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha.
Hu, E., Tontonoz, P., & Spiegelman, B. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.21.9856 · Cited by 660
Long-term testosterone gel (AndroGel) treatment maintains beneficial effects on sexual function and mood, lean and fat mass, and bone mineral density in hypogonadal men
Wang, C., Cunningham, G., Dobs, A., Iranmanesh, A., Matsumoto, A. M., Snyder, P. J., Weber, T., Berman, N., Hull, L., & Swerdloff, R. S. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032006 · Cited by 656
Exogenous Testosterone (T) Alone or with Finasteride Increases Physical Performance, Grip Strength, and Lean Body Mass in Older Men with Low Serum T
Page, S. T., Amory, J. K., Bowman, F. D., Anawalt, B. D., Matsumoto, A. M., Bremner, W. J., & Tenover, J. L. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1933 · Cited by 566
Androgens Stimulate Myogenic Differentiation and Inhibit Adipogenesis in C3H 10T1/2 Pluripotent Cells through an Androgen Receptor-Mediated Pathway
Singh, R., Artaza, J. N., Taylor, W. E., Gonzalez-Cadavid, N. F., & Bhasin, S. (2003) · Endocrinology · doi:10.1210/en.2003-0741 · Cited by 555
Association of Specific Symptoms and Metabolic Risks with Serum Testosterone in Older Men
Zitzmann, M., Faber, S., & Nieschlag, E. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0401 · Cited by 552
Transdifferentiation of mouse aortic smooth muscle cells to a macrophage-like state after cholesterol loading
Rong, J. X., Shapiro, M., Trogan, E., & Fisher, E. A. A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1735526100 · Cited by 551
Effects of testosterone on sexual function in men: results of a meta‐analysis
Isidori, A. M., Giannetta, E., Gianfrilli, D., Greco, E. A., Bonifacio, V., Aversa, A., Isidori, A., Fabbri, A., & Lenzi, A. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02350.x · Cited by 492 · cited 3×
“They concluded that the effect of testosterone tended to decline over time and was progressively smaller with increasing baseline T levels, and that long-term safety data were not available [146].”
BackgroundInfluential
Exogenous Testosterone or Testosterone with Finasteride Increases Bone Mineral Density in Older Men with Low Serum Testosterone
Amory, J. K., Watts, N. B., Easley, K. A., Sutton, P. R., Anawalt, B. D., Matsumoto, A. M., Bremner, W. J., & Tenover, J. L. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031110 · Cited by 475
Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor
Clark, R. V., Hermann, D. J., Cunningham, G. R., Wilson, T. H., Morrill, B. B., & Hobbs, S. F. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030330 · Cited by 470
Premature Ejaculation: An Observational Study of Men and Their Partners
Patrick, D. L., Althof, S. E., Pryor, J. L., Rosen, R. C., Rowland, D. L., Ho, K. F., McNulty, P., Rothman, M. L., & Jamieson, C. (2005) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2005.20353.x · Cited by 470
Multicenter Study on the Prevalence of Sexual Symptoms in Male Hypo- and Hyperthyroid Patients
Carani, C., Isidori, A. M., Granata, A. R. M., Carosa, E., Maggi, M., Lenzi, A., & Jannini, E. A. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1135 · Cited by 417
AA2500 Testosterone Gel Normalizes Androgen Levels in Aging Males with Improvements in Body Composition and Sexual Function
Steidle, C. P., Schwartz, S. L., Jacoby, K., Sebree, T. B., Smith, T. P. L., & Bachand, R. T. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021058 · Cited by 409
Pharmacokinetics, Efficacy, and Safety of a Permeation-Enhanced Testosterone Transdermal System in Comparison with Bi-Weekly Injections of Testosterone Enanthate for the Treatment of Hypogonadal Men
Dobs, A. S. (1999) · Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.10.3469 · Cited by 381
A Synthetic Antagonist for the Peroxisome Proliferator-activated Receptor γ Inhibits Adipocyte Differentiation
Wright, H. M., Clish, C. B., Mikami, T., Hauser, S., Yanagi, K., Hiramatsu, R., Serhan, C. N., & Spiegelman, B. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.3.1873 · Cited by 371
Summary of the Recommendations on Sexual Dysfunctions in Men
Lue, T. F., Giuliano, F., Montorsi, F., Rosen, R. C., Andersson, K., Althof, S. E., Christ, G. J., Hatzichristou, D. G., Hirsch, M., Kimoto, Y., et al. (2004) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2004.10104.x · Cited by 370
Testosterone Inhibits Adipogenic Differentiation in 3T3-L1 Cells: Nuclear Translocation of Androgen Receptor Complex with β-Catenin and T-Cell Factor 4 May Bypass Canonical Wnt Signaling to Down-Regulate Adipogenic Transcription Factors
Singh, R., Artaza, J. N., Taylor, W. E., Braga, M., Yuan, X., Gonzalez-Cadavid, N. F., & Bhasin, S. (2006) · Endocrinology · doi:10.1210/en.2004-1649 · Cited by 369
The backdoor pathway to dihydrotestosterone
Auchus, R. J. (2004) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2004.09.004 · Cited by 347
Investigation, Treatment, and Monitoring of Late-Onset Hypogonadism in Males: ISA, ISSAM, EAU, EAA, and ASA Recommendations
Wang, C., Nieschlag, E., Swerdloff, R. S., Behre, H. M., Hellstrom, W. J. G., Gooren, L. J., Kaufman, J., Legros, J.-J., Lunenfeld, B., Morales, Á., et al. (2008) · European Urology · doi:10.1016/j.eururo.2008.08.033 · Cited by 346
Androgens improve cavernous vasodilation and response to sildenafil in patients with erectile dysfunction
Aversa, A., Isidori, A. M., Spera, G., Lenzi, A., & Fabbri, A. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01764.x · Cited by 343
Androgens Regulate Phosphodiesterase Type 5 Expression and Functional Activity in Corpora Cavernosa
Morelli, A., Filippi, S., Mancina, R., Luconi, M., Vignozzi, L., Marini, M., Orlando, C., Vannelli, G. B., Aversa, A., Natali, A., et al. (2004) · Endocrinology · doi:10.1210/en.2003-1699 · Cited by 337
Binding properties of androgen receptors. Evidence for identical receptors in rat testis, epididymis, and prostate.
Wilson, E. M., & French, F. S. (1976) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)33103-4 · Cited by 312
Effects of Castration and Androgen Replacement on Erectile Function in a Rabbit Model1
Traish, A. M., Park, K., Dhir, V., Kim, N. N., Moreland, R. B., & Goldstein, I. (1999) · Endocrinology · doi:10.1210/endo.140.4.6655 · Cited by 305
Self-citation
Dehydroepiandrosterone Activates Endothelial Cell Nitric-oxide Synthase by a Specific Plasma Membrane Receptor Coupled to Gαi2,3
Liu, D., & Dillon, J. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200491200 · Cited by 285
Investigation, treatment and monitoring of late‐onset hypogonadism in males: ISA, ISSAM, and EAU recommendations
NIESCHLAG, E., SWERDLOFF, R., BEHRE, H. M., GOOREN, L. J., KAUFMAN, J. M., LEGROS, J. ‐., LUNENFELD, B., MORLEY, J. E., SCHULMAN, C., WANG, C., et al. (2005) · International Journal of Andrology · doi:10.1111/j.1365-2605.2005.00553.x · Cited by 282
Dihydrotestosterone is the active androgen in the maintenance of nitric oxide-mediated penile erection in the rat
Lugg, J., Rajfer, J., & González-Cadavid, N. F. (1995) · Endocrinology · doi:10.1210/endo.136.4.7534702 · Cited by 278
Changes in sex hormone‐binding globulin and testosterone during weight loss and weight maintenance in abdominally obese men with the metabolic syndrome
Niskanen, L., Laaksonen, D. E., Punnonen, K., Mustajoki, P., Kaukua, J., & Rissanen, A. (2004) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1462-8902.2004.00335.x · Cited by 275
Pharmacotherapy for Erectile Dysfunction
Ian Eardley, C., Donatucci, C. F., Corbin, J. D., El-Meliegy, A., Konstantinos Hatzimouratidis, A., McVary, K. T., Munarriz, R. M., & Lee, S. W. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01627.x · Cited by 254
ENDOCRINE SCREENING IN 1,022 MEN WITH ERECTILE DYSFUNCTION: CLINICAL SIGNIFICANCE AND COST-EFFECTIVE STRATEGY
Buvat, J., & Lemaire, A. (1997) · The Journal of Urology · doi:10.1016/s0022-5347(01)64123-5 · Cited by 248
Adipose Tissue Intracrinology: Potential Importance of Local Androgen/Estrogen Metabolism in the Regulation of Adiposity
Bélanger, C., Luu-The, V., Dupont, P., & Tchernof, A. (2002) · Hormone and Metabolic Research · doi:10.1055/s-2002-38265 · Cited by 246
The Biological Actions of Dehydroepiandrosterone Involves Multiple Receptors
Webb, S. J., Geoghegan, T. E., Prough, R. A., & Miller, K. K. M. (2006) · Drug Metabolism Reviews · doi:10.1080/03602530600569877 · Cited by 235
Bisphenol A in combination with insulin can accelerate the conversion of 3T3-L1 fibroblasts to adipocytes
Masuno, H., Kidani, T., Sekiya, K., Sakayama, K., Shiosaka, T., Yamamoto, H., & Honda, K. (2002) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)30108-5 · Cited by 233
The Mechanisms of Androgen Effects on Body Composition: Mesenchymal Pluripotent Cell as the Target of Androgen Action
Bhasin, S., Taylor, W. E., Singh, R., Artaza, J., Sinha-Hikim, I., Jasuja, R., Choi, H., & Gonzalez-Cadavid, N. F. (2003) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/58.12.m1103 · Cited by 215
Sex Hormones and Sexual Function in Obese Men Losing Weight
Kaukua, J., Pekkarinen, T., Sane, T., & Mustajoki, P. (2003) · Obesity Research · doi:10.1038/oby.2003.98 · Cited by 212
Impotence Is Not Always Psychogenic
Spark, R. F. (1980) · JAMA · doi:10.1001/jama.243.8.750 · Cited by 205
Construction and field validation of a self‐administered screener for testosterone deficiency (hypogonadism) in ageing men
Smith, K. W., Feldman, H. A., & McKinlay, J. B. (2000) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2000.01152.x · Cited by 203
Investigation, Treatment and Monitoring of Late-Onset Hypogonadism in Males
Nieschlag, E., Swerdloff, R. S., Hm, B., Gooren, L. J., Kaufman, J., Legros, J.-J., Lunenfeld, B., Morley, J. E., Schulman, C., Wang, C., et al. (2005) · European Urology · doi:10.1016/j.eururo.2005.04.027 · Cited by 201
Androgen receptors in human preadipocytes and adipocytes: regional specificities and regulation by sex steroids
Dieudonné, M., Pecquery, R., Boumédiène, A., Leneveu, M.-C., & Giudicelli, Y. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.274.6.c1645 · Cited by 197
Are androgens critical for penile erections in humans? Examining the clinical and preclinical evidence
Traish, A. M., & Guay, A. T. (2006) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2006.00245.x · Cited by 196
Self-citation
Testosterone Regulates PDE5 Expression and in vivo Responsiveness to Tadalafil in Rat Corpus Cavernosum
Zhang, X., Morelli, A., Luconi, M., Vignozzi, L., Filippi, S., Marini, M., Vannelli, G. B., Mancina, R., Forti, G., & Maggi, M. (2004) · European Urology · doi:10.1016/j.eururo.2004.10.021 · Cited by 193
On Swedish Women's Distressing Sexual Dysfunctions: Some Concomitant Conditions and Life Satisfaction
Öberg, K. G., & Fugl-Meyer, K. S. (2005) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2005.20226.x · Cited by 191
Intramuscular Testosterone Undecanoate: Pharmacokinetic Aspects of a Novel Testosterone Formulation during Long-Term Treatment of Men with Hypogonadism
Schubert, M., Minnemann, T., Hübler, D., Rouskova, D., Christoph, A., Oettel, M., Ernst, M. E., Mellinger, U., Krone, W., & Jockenhövel, F. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0897 · Cited by 187
Intracavernosal vascular endothelial growth factor (VEGF) injection and adeno-associated virus-mediated VEGF gene therapy prevent and reverse venogenic erectile dysfunction in rats
Rogers, R. S., GRAZIOTTIN, T. M., Lin, C.-S., Kan, Y. W., & Lue, T. F. (2003) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3900943 · Cited by 183
What Can Animal Models Tell Us about Human Sexual Response?
Pfaus, J. G., Kippin, T. E., & Coria‐Ávila, G. A. (2003) · Annual Review of Sex Research · doi:10.1080/10532528.2003.10559810 · Cited by 182
Endocrine Aspects of Sexual Dysfunction in Men
Morales, Á., Buvat, J., Gooren, L. J., Guay, A. T., Kaufman, J., Tan, H. M., & Torres, L. O. (2004) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2004.10111.x · Cited by 178
The Physiological Role of Androgens in Penile Erection: Regulation of Corpus Cavernosum Structure and Function
Traish, A. M., & Kim, N. N. (2005) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2005.00094.x · Cited by 170
Self-citation
Effects of Medical or Surgical Castration on Erectile Function in an Animal Model
Traish, A. M., Munarriz, R. M., O'Connell, L., Choi, S., Kim, S. W., Kim, N. N., Huang, Y.-H., & Goldstein, I. (2003) · Journal of Andrology · doi:10.1002/j.1939-4640.2003.tb02686.x · Cited by 168
Self-citation
Comparison of screening questionnaires for the diagnosis of hypogonadism
Morley, J. E., Perry, H. M., Kevorkian, R. T., & Patrick, P. (2006) · Maturitas · doi:10.1016/j.maturitas.2005.07.004 · Cited by 168
Women's Sexual Function Improves When Partners are Administered Vardenafil for Erectile Dysfunction: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial
Goldstein, I., Fisher, W. A., Sand, M. S., Rosen, R. C., Mollen, M. D., Brock, G. B., KARLIN, G. S., Pommerville, P. J., Bangerter, K., Bandel, T.-J., et al. (2005) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2005.00147.x · Cited by 163
Self-citation
Differential Regulation of Gonadotropin Secretion by Testosterone in the Human Male: Absence of a Negative Feedback Effect of Testosterone on Follicle-Stimulating Hormone Secretion
Hayes, F. J., DeCruz, S., Seminara, S. B., Boepple, P. A., & Crowley, W. F. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.1.7101 · Cited by 159
Hyperprolactinemia and sexual function in men: a short review
Buvat, J. (2003) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901043 · Cited by 159
PLASMA ANDROGEN LEVELS IN MEN AFTER ORAL ADMINISTRATION OF TESTOSTERONE OR TESTOSTERONE UNDECANOATE
Nieschlag, E., Mauss, J., Coert, A., & Kicovic, P. M. (1975) · European Journal of Endocrinology · doi:10.1530/acta.0.0790366 · Cited by 158
Expression of Peroxisome Proliferator-Activated Receptor and CCAAT/Enhancer Binding Protein Transcription Factors in Cultured Human Sebocytes
Chen, W., Yang, C.-C., Sheu, H.-M., Seltmann, H., & Zouboulis, C. C. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12411.x · Cited by 157
Effect of raising endogenous testosterone levels in impotent men with secondary hypogonadism: double blind placebo-controlled trial with clomiphene citrate
Guay, A. T., Bansal, S., & Heatley, G. J. (1995) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.80.12.8530597 · Cited by 149
Effects of Aromatase Inhibition in Elderly Men with Low or Borderline-Low Serum Testosterone Levels
Leder, B. Z., Rohrer, J. L., Rubin, S. D., Gallo, J., & Longcope, C. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031467 · Cited by 149
Adipocyte Accumulation in Penile Corpus Cavernosum of the Orchiectomized Rabbit: A Potential Mechanism for Veno‐occlusive Dysfunction in Androgen Deficiency
Traish, A. M., Toselli, P. A., Jeong, S., & Kim, N. N. (2005) · Journal of Andrology · doi:10.1002/j.1939-4640.2005.tb01091.x · Cited by 148
Self-citation
Improving the Sexual Quality of Life of Couples Affected by Erectile Dysfunction: A Double–Blind, Randomized, Placebo–Controlled Trial of Vardenafil
Fisher, W. A., Rosen, R. C., Mollen, M. D., Brock, G. B., KARLIN, G. S., Pommerville, P. J., Goldstein, I., Bangerter, K., Bandel, T.-J., Derogatis, L. R., et al. (2005) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2005.00119.x · Cited by 148
Self-citation
Androgenic Regulation of NO Availability in Rat Penile Erection
Reilly, C. M., Zamorano, P. L., Stopper, V. S., & MILLS, T. M. (1997) · Journal of Andrology · doi:10.1002/j.1939-4640.1997.tb01890.x · Cited by 144
Testosterone Restores Diabetes-Induced Erectile Dysfunction and Sildenafil Responsiveness in Two Distinct Animal Models of Chemical Diabetes
Zhang, X., Filippi, S., Morelli, A., Vignozzi, L., Luconi, M., Donati, S., Forti, G., & Maggi, M. (2006) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2006.00207.x · Cited by 138
Testosterone treatment comes of age: new options for hypogonadal men
Nieschlag, E. (2006) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2006.02618.x · Cited by 137
Clinical and hormonal characteristics of central hypothyroidism at diagnosis and during follow-up in adult patients
Alexopoulou, O., Beguin, C., De Nayer, P., & Maiter, D. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1500001 · Cited by 135
Nitric oxide mediated erectile activity is a testosterone dependent event: a rat erection model.
Zvara, P., Sioufi, R., Schipper, H. M., Bégin, L. R., & Brock, G. B. (1995) · PubMed · Cited by 134
Androgen and Pituitary Control of Penile Nitric Oxide Synthase and Erectile Function in the Rat1
Penson, D. F., Ng, C. S., Cai, L., Rajfer, J., & González-Cadavid, N. F. (1996) · Biology of Reproduction · doi:10.1095/biolreprod55.3.567 · Cited by 132
ANDROTEST: A structured interview for the screening of hypogonadism in patients with sexual dysfunction
Corona, G., Mannucci, E., Petrone, L., Balercia, G., Fisher, A. D., Chiarini, V., Forti, G., & Maggi, M. (2006) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2006.00262.x · Cited by 130
Impact of medical treatments for benign prostatic hyperplasia on sexual function
Giuliano, F. (2006) · British Journal of Urology · doi:10.1111/j.1464-410x.2006.06104.x · Cited by 129
Selective facilitation of sexual solicitation in the female rat by a melanocortin receptor agonist
Pfaus, J. G., Shadiack, A. M., Soest, T. V., Tse, M., & Molinoff, P. B. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400491101 · Cited by 128
Clomiphene increases free testosterone levels in men with both secondary hypogonadism and erectile dysfunction: who does and does not benefit?
Guay, A. T., Jacobson, J., Perez, J. B., Hodge, M. B., & Velasquez, E. (2003) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3900981 · Cited by 128
Effect of aging on nitric oxide-mediated penile erection in rats
Garbán, H., Vernet, D. A., Freedman, A. I., Rajfer, J., & González-Cadavid, N. F. (1995) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1995.268.1.h467 · Cited by 128
A mathematical comparison of techniques to predict biologically available testosterone in a cohort of 1072 men
Morris, P., Malkin, C., Channer, K., & Jones, T. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1510241 · Cited by 122
Long‐term substitution therapy of hypogonadal men with transscrotal testosterone over 7–10 years
Behre, H. M., von Eckardstein, S., Kliesch, S., & Nieschlag, E. (1999) · Clinical Endocrinology · doi:10.1046/j.1365-2265.1999.00705.x · Cited by 122
Androgen-Dependent Nitric Oxide Release in Rat Penis Correlates with Levels of Constitutive Nitric Oxide Synthase Isoenzymes1
Marín, R., Escrig, A. M., Abreu, P. M., & Mas, M. (1999) · Biology of Reproduction · doi:10.1095/biolreprod61.4.1012 · Cited by 121
Dopamine and Male Sexual Function
Giuliano, F., & Allard, J. (2001) · European Urology · doi:10.1159/000049844 · Cited by 119
Differential Regulation of Gonadotropin Secretion by Testosterone in the Human Male: Absence of a Negative Feedback Effect of Testosterone on Follicle-Stimulating Hormone Secretion
Hayes, F. J. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.1.53 · Cited by 119
Androgen Replacement Therapy
Gooren, L. J., & Bunck, M. C. M. (2004) · Drugs · doi:10.2165/00003495-200464170-00002 · Cited by 118
DOES SILDENAFIL COMBINED WITH TESTOSTERONE GEL IMPROVE ERECTILE DYSFUNCTION IN HYPOGONADAL MEN IN WHOM TESTOSTERONE SUPPLEMENT THERAPY ALONE FAILED?
Greenstein, A., Mabjeesh, N. J., Sofer, M., Kaver, I., Matzkin, H., & Chen, J. (2005) · The Journal of Urology · doi:10.1097/01.ju.0000149870.36577.05 · Cited by 116
Effects of androgens on the expression of nitric oxide synthase mRNAs in rat corpus cavernosum
Park, Kim, Kim, & Paick (1999) · British Journal of Urology · doi:10.1046/j.1464-410x.1999.00913.x · Cited by 114
Reduced Number of Circulating Endothelial Progenitor Cells in Hypogonadal Men
Foresta, C., Caretta, N., Lana, A., Toni, L. D., Biagioli, A., Ferlin, A., & Garolla, A. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-0763 · Cited by 114
Physiology of Female Sexual Function: Animal Models
Giraldi, A. G. E., Marson, L., Nappi, R. E., Pfaus, J. G., Traish, A. M., Vardi, Y., & Goldstein, I. (2004) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.04037.x · Cited by 109
Self-citation
Can results of the Aging Males' Symptoms (AMS) scale predict those of screening scales for androgen deficiency?
Heinemann, L., Saad, F., Heinemann, K., & Thai, D. (2004) · The Aging Male · doi:10.1080/13685530400004223 · Cited by 109
Delayed testosterone replacement restores nitric oxide synthase‐containing nerve fibres and the erectile response in rat penis
Baba, K., Yajima, M., A., C. S., Morgan, D. M., Nunes, L., Lue, T. F., & Iwamoto, T. (2000) · British Journal of Urology · doi:10.1046/j.1464-410x.2000.00598.x · Cited by 107
Combining Testosterone and PDE5 Inhibitors in Erectile Dysfunction: Basic Rationale and Clinical Evidences
Greco, E. A., Spera, G., & Aversa, A. (2006) · European Urology · doi:10.1016/j.eururo.2006.06.049 · Cited by 106
Injury Induces Dedifferentiation of Smooth Muscle Cells and Increased Matrix-Degrading Metalloproteinase Activity in Human Saphenous Vein
Johnson, J. L., van Eys, G. J. J. M., Angelini, G. D., & George, S. J. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0701.092106 · Cited by 106
Dedifferentiation of atrial myocytes during atrial fibrillation: role of fibroblast proliferation in vitro
Rücker‐Martin, C. (2002) · Cardiovascular Research · doi:10.1016/s0008-6363(02)00338-3 · Cited by 102
Interest of the Androgen Deficiency in Aging Males (ADAM) questionnaire for the identification of hypogonadism in elderly community-dwelling male volunteers
Tancredi, A., Reginster, J., Schleich, F., Pire, G., Maassen, P., Luyckx, F., & Legros, J. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1510355 · Cited by 102
Clomiphene citrate effects on testosterone/estrogen ratio in male hypogonadism
Shabsigh, A., Kang, Y., Shabsign, R., Gonzalez, M., Liberson, G., Fisch, H., & Goluboff, E. (2005) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2005.00075.x · Cited by 98
Comparison of Testosterone, Dihydrotestosterone, Luteinizing Hormone, and Follicle-Stimulating Hormone in Serum after Injection of Testosterone Enanthate or Testosterone Cypionate
Schulte-Beerbühl, M., & Nieschlag, E. (1980) · Fertility and Sterility · doi:10.1016/s0015-0282(16)44543-7 · Cited by 96
Molecular Mechanisms of Adipocyte Differentiation
Tong, Q., & Hotamışlıgil, G. S. (2001) · Reviews in Endocrine and Metabolic Disorders · doi:10.1023/a:1011863414321 · Cited by 91
Revisiting the Concept of Sexual Motivation
Pfaus, J. G. (1999) · Annual Review of Sex Research · doi:10.1080/10532528.1999.10559777 · Cited by 90
Effect of androgen deprivation on penile ultrastructure.
Shen, Z., Zhou, X.-L., Lu, Y., & Chen, Z.-D. (2003) · PubMed · Cited by 89
The preclinical pharmacology of “Arimidex” (Anastrozole; ZD1033) — a potent, selective aromatase inhibitor
Dukes, M., Edwards, P. N., Large, M. S., Smith, I. K., & Boyle, T. (1996) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(96)00064-7 · Cited by 89
Hormonal Supplementation and Erectile Dysfunction
Aversa, A., Isidori, A. M., Greco, E. A., Giannetta, E., Gianfrilli, D., Spera, E., & Fabbri, A. (2004) · European Urology · doi:10.1016/j.eururo.2004.01.005 · Cited by 89
Androgens Modulate Nitric Oxide Synthase Messenger Ribonucleic Acid Expression in Neurons of the Major Pelvic Ganglion in the Rat
SCHIRAR, A., Bonnefond, C., Meusnier, C., & Devinoy, È. (1997) · Endocrinology · doi:10.1210/endo.138.8.5310 · Cited by 88
Testosterone and sexual activity.
Vignozzi, L., Corona, G., Petrone, L., Filippi, S., Morelli, A., Forti, G., & Maggi, M. (2005) · PubMed · Cited by 88
Androgen therapy with dehydroepiandrosterone
Buvat, J. (2003) · World Journal of Urology · doi:10.1007/s00345-003-0367-7 · Cited by 87
TESTOSTERONE PROPIONATE THERAPY IN ONE HUNDRED CASES OF ANGINA PECTORIS
Lesser, M. A. (1946) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-6-8-549 · Cited by 87
Testosterone Therapy Can Enhance Erectile Function Response to Sildenafil in Patients with PADAM: A Pilot Study
Shamloul, R. M., Ghanem, H. M., Fahmy, I., El-Meleigy, A., Ashoor, S., El-Nashaar, A., & Kamel, I. (2005) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2005.00071.x · Cited by 86
Wide Variability in Laboratory Reference Values for Serum Testosterone
Lazarou, S., Reyes-Vallejo, L., & Morgentaler, A. (2006) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2006.00334.x · Cited by 83
Contribution of dihydrotestosterone to male sexual behaviour
Mantzoros, C. S., Georgiadis, E. I., & Trichopoulos, D. (1995) · BMJ · doi:10.1136/bmj.310.6990.1289 · Cited by 83
Androgenic Maintenance of the Rat Erectile Response Via a Non‐Nitric‐Oxide‐Dependent Pathway
Reilly, C. M., Lewis, R. W., Stopper, V., & MILLS, T. M. (1997) · Journal of Andrology · doi:10.1002/j.1939-4640.1997.tb02435.x · Cited by 82
Adjunctive use of AndroGel (testosterone gel) with sildenafil to treat erectile dysfunction in men with acquired androgen deficiency syndrome after failure using sildenafil alone
Rosenthal, B. D., May, N. R., METRO, M. J., Harkaway, R. C., & Ginsberg, P. C. (2006) · Urology · doi:10.1016/j.urology.2005.09.032 · Cited by 82
Testosterone Therapy in Erectile Dysfunction and Hypogonadism
Shabsigh, R. (2005) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2005.00139.x · Cited by 81
Middle-Aged Men Secrete Less Testosterone at Night Than Young Healthy Men
Luboshitzky, R., Shen‐Orr, Z., & Herer, P. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021920 · Cited by 81
Effect of testosterone on the number of NADPH diaphorase-stained nerve fibers in the rat corpus cavernosum and dorsal nerve
Baba, K., Yajima, M., A., C. S., Akkuş, E., Reman, J., Nunes, L., Lue, T. F., & Iwamoto, T. (2000) · Urology · doi:10.1016/s0090-4295(00)00667-1 · Cited by 79
The regulation of HSL and LPL expression by DHT and flutamide in human subcutaneous adipose tissue
Anderson, L. A., McTernan, P. G., Harte, A. L., Barnett, A. H., & Kumar, S. (2002) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2002.00214.x · Cited by 75
Relationship between serum sex steroids and Aging Male Symptoms score and International Index of Erectile Function
Başar, M., Aydın, G., Mert, H. C., Keleş, I., Çağlayan, O., Orkun, S., & Batı̇slam, E. (2005) · Urology · doi:10.1016/j.urology.2005.03.060 · Cited by 75
The evolving role of testosterone in the treatment of erectile dysfunction
Shabsigh, R., Rajfer, J., Aversa, A., Traish, A. M., Yassin, A. A., Kalinchenko, S. Y., & BUVAT, J. (2006) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2006.01101.x · Cited by 73
Self-citation
Autonomie Control of Penile Erection: Modulation by Testosterone in the Rat
Giuliano, F., Rampint, O., SCHIRAR, A., Jardin, A., & Rousseau, J.-P. (1993) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1993.tb00539.x · Cited by 71
Diagnostic Steps In The Evaluation Of Patients With Erectile Dysfunction
Hatzichristou, D. G., Konstantinos Hatzimouratidis, A., Bekas, M., Apostolidis, A., Tzortzis, V., & Yannakoyorgos, K. (2002) · The Journal of Urology · doi:10.1016/s0022-5347(05)64690-3 · Cited by 70
Testosterone Propionate in the Treatment of Angina Pectoris
HAMM, L. (1942) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-2-5-325 · Cited by 70
A Comparison of a Novel Testosterone Bioadhesive Buccal System, Striant, with a Testosterone Adhesive Patch in Hypogonadal Males
Korbonits, M., Slawik, M., Cullen, D. R., Ross, R. J. M., Stalla, G. K., Schneider, H., Reincke, M., Bouloux, P. M., & Grossman, A. B. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030319 · Cited by 70
Laboratory Evaluations of Erectile Dysfunction: An Evidence Based Approach
Bodie, J., LEWIS, J., Schow, D. A., & Monga, M. (2003) · The Journal of Urology · doi:10.1097/01.ju.0000063940.19080.58 · Cited by 69
Dedifferentiation of stromal smooth muscle as a factor in prostate carcinogenesis
Wong, Y. C., & Tam, N. N. C. (2002) · Differentiation · doi:10.1046/j.1432-0436.2002.700916.x · Cited by 69
Smooth Muscle Cell Behavior in the Ventral Prostate of Castrated Rats
Antonioli, E., Della‐Colleta, H. H. M., & Carvalho, H. F. (2004) · Journal of Andrology · doi:10.1002/j.1939-4640.2004.tb02758.x · Cited by 65
Inhibition of 5-α-reductase activity induces stromal remodeling and smooth muscle de-differentiation in adult gerbil ventral prostate
Corradi, L. S., Carvalho, H. F., Góes, R. M., & Taboga, S. R. (2004) · Differentiation · doi:10.1111/j.1432-0436.2004.07205004.x · Cited by 64
Testosterone therapy - what, when and to whom?
Jockenhövel, F. (2004) · The Aging Male · doi:10.1080/13685530400016557 · Cited by 63
Recent insights into androgen action on the anatomical and physiological substrate of penile erection
Gooren, L. J., & Saad, F. (2006) · Asian Journal of Andrology · doi:10.1111/j.1745-7262.2006.00105.x · Cited by 62
Testosterone Treatment In Hypogonadal Men: Prostate-Specific Antigen Level And Risk Of Prostate Cancer
Guay, A. T., Perez, J. B., Fitaihi, W. A., & Vereb, M. J. (2000) · Endocrine Practice · doi:10.4158/ep.6.2.132 · Cited by 61
Sexual Dysfunction in Female Partners of Men Who Have Undergone Radical Prostatectomy Correlates with Sexual Dysfunction of the Male Partner
Shindel, A. W., Quayle, S. S., Yan, Y., Husain, A., & Naughton, C. K. (2005) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2005.00148.x · Cited by 61
Testosterone and nerve growth factor have distinct but interacting effects on structure and neurotransmitter expression of adult pelvic ganglion cells in vitro
Meusburger, S. M., & Keast, J. R. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00420-1 · Cited by 59
Impotence Is Not Always Psychogenic
Kavich‐Sharon, R. (1980) · JAMA · doi:10.1001/jama.1980.03310140018013 · Cited by 58
Treatment of hirsutism and acne in hyperandrogenism
Moghetti, P., & Toscano, V. (2006) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2006.03.003 · Cited by 57
The effects of androgen on penile reflex, erectile response to electrical stimulation and penile NOS activity in the rat.
Seo, S. I., Kim, S. W., & Paick, J. (1999) · PubMed · Cited by 56
Dose—Response Relationship Between Testosterone and Erectile Function: Evidence for the Existence of a Critical Threshold
Armağan, A., Kim, N. N., Goldstein, I., & Traish, A. M. (2006) · Journal of Andrology · doi:10.2164/jandrol.05157 · Cited by 56
Self-citation
Peripheral regulatory mechanisms in erection
Morelli, A., Filippi, S., ZHANG, X. ‐., Luconi, M., Vignozzi, L., Mancina, R., & Maggi, M. (2005) · International Journal of Andrology · doi:10.1111/j.1365-2605.2005.00550.x · Cited by 55
Treatment of lower urinary tract symptoms in benign prostatic hyperplasia and its impact on sexual function
Miner, M. M., Rosenberg, M. T., & Perelman, M. A. (2006) · Clinical Therapeutics · doi:10.1016/j.clinthera.2006.01.004 · Cited by 55
Testosterone Propionate as a Therapeutic Agent in Patients with Organic Disease of the Peripheral Vessels
EDWARDS, E. A., Hamilton, J. B., & Duntley, S. Q. (1939) · New England Journal of Medicine · doi:10.1056/nejm193905252202103 · Cited by 53
The ageing male
Schulman, C., & Lunenfeld, B. (2002) · World Journal of Urology · doi:10.1007/s00345-002-0258-3 · Cited by 53
Testosterone Replacement Therapy for Older Men
Wald, M., Meacham, R. B., Ross, L. S., & NIEDERBERGER, C. S. (2006) · Journal of Andrology · doi:10.2164/jandrol.05036 · Cited by 52
Abnormal Morphology of the Penis in Male Rats Exposed Neonatally to Diethylstilbestrol Is Associated with Altered Profile of Estrogen Receptor-α Protein, but Not of Androgen Receptor Protein: A Developmental and Immunocytochemical Study1
Goyal, H. O., Braden, T. D., Williams, C. S., Dalvi, P. S., Mansour, M. M., Mansour, M. M., Williams, J. W., Bartol, F. F., Wiley, A. A., Birch, L. A., et al. (2004) · Biology of Reproduction · doi:10.1095/biolreprod.103.026328 · Cited by 51
Aromatase inhibition, testosterone, and seizures
Harden, C. L., & MacLusky, N. J. (2004) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2003.12.001 · Cited by 50
Dehydroepiandrosterone in the treatment of erectile dysfunction in patients with different organic etiologies
REITER, W. J., Schatzl, G., Märk, I., Zeiner, A., Pycha, A., & Marberger, M. (2001) · Urological Research · doi:10.1007/s002400100189 · Cited by 50
THE EFFECT OF PARENTERAL TESTOSTERONE REPLACEMENT ON PROSTATE SPECIFIC ANTIGEN IN HYPOGONADAL MEN WITH ERECTILE DYSFUNCTION
Svetec, D. A., Canby, E. D., Thompson, I. M., & Sabanegh, E. S. (1997) · The Journal of Urology · doi:10.1016/s0022-5347(01)64126-0 · Cited by 50
Androgen therapy in the aging male
Lunenfeld, B. (2003) · World Journal of Urology · doi:10.1007/s00345-003-0366-8 · Cited by 48
Pharmacotherapy for Erectile Dysfunction
Padma-Nathan, H., Christ, G. J., Adaikan, G. P., Becher, E. F., Brock, G. B., A., C. S., Carson, C. C., Corbin, J. D., Francis, S., DeBusk, R. F., et al. (2004) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2004.04021.x · Cited by 48
The Therapeutic Value of Testosterone Propionate in Angina Pectoris
Levine, S. A., & LIKOFF, W. B. (1943) · New England Journal of Medicine · doi:10.1056/nejm194311182292102 · Cited by 44
AN ANALYSIS OF ONE THOUSAND TESTICULAR SUBSTANCE IMPLANTATIONS
STANLEY, L. L. (1922) · Endocrinology · doi:10.1210/endo-6-6-787 · Cited by 44
Comparison of the steady-state pharmacokinetics, metabolism, and variability of a transdermal testosterone patch versus a transdermal testosterone gel in hypogonadal men
Mazer, N., Bell, D., Wu, J., Fischer, J., Cosgrove, M., & Eilers, B. (2005) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2005.20231.x · Cited by 44
Castration and Erection
Muller, S., Hsieh, J., Lue, T. F., & Tanagho, E. A. (1988) · European Urology · doi:10.1159/000473410 · Cited by 43
Testosterone: Estradiol Ratio Changes Associated with Long-Term Tadalafil Administration: A Pilot Study
Greco, E. A., Pili, M., Bruzziches, R., Corona, G., Spera, G., & Aversa, A. (2006) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2006.00264.x · Cited by 42
Bisphenol A inhibits penile erection via alteration of histology in the rabbit
Moon, D. G., Sung, D., Kim, Y., Cheon, J., & Jj, K. (2001) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3900734 · Cited by 41
Increased estradiol levels in venous occlusive disorder: a possible functional mechanism of venous leakage
Mancini, A., Milardi, D., Bianchi, A., Summaria, V., & Marinis, L. D. (2004) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901287 · Cited by 40
Testosterone levels in men with erectile dysfunction
Martínez‐Jabaloyas, J. M., Zaragoza, A. Q., Pastor-Hernández, F., Gil‐Salom, M., & Chuan-Nuez, P. (2006) · British Journal of Urology · doi:10.1111/j.1464-410x.2006.06154.x · Cited by 40
Prostate cancer: epidemiology and screening.
Brawer, M. K., Ed, C., Fowler, J. E., Lucia, M. S., & Schroeder, F. H. (2000) · Europe PMC (PubMed Central) · Cited by 40
Erectile dysfunction and lower androgenicity in type 1 diabetic patients.
Alexopoulou, O., Jamart, J., Maiter, D. M., Hermans, M. P., Hertogh, R. D., Nayer, P. D., & Buysschaert, M. (2001) · PubMed · Cited by 38
Effect of Testosterone on Intracavernous Pressure Elicited With Electrical Stimulation of the Medial Preoptic Area and Cavernous Nerve in Male Rats
Suzuki, N., Sato, Y., Hisasue, S., Kato, R., Suzuki, K., & Tsukamoto, T. (2007) · Journal of Andrology · doi:10.2164/jandrol.106.000695 · Cited by 37
Estrogen-Induced Abnormal Accumulation of Fat Cells in the Rat Penis and Associated Loss of Fertility Depends upon Estrogen Exposure during Critical Period of Penile Development
Goyal, H. O., Braden, T. D., Williams, C. S., Dalvi, P. S., Mansour, M. M., & Williams, J. W. (2005) · Toxicological Sciences · doi:10.1093/toxsci/kfi233 · Cited by 37
Exposure of neonatal male rats to estrogen induces abnormal morphology of the penis and loss of fertility
Goyal, H. O., Braden, T. D., Williams, C. S., Dalvi, P. S., Williams, J. W., & Srivastava, K. K. (2004) · Reproductive Toxicology · doi:10.1016/j.reprotox.2003.12.001 · Cited by 34
The role of estradiol in the maintenance of secondary hypogonadism in males in erectile dysfunction
Cohen, P. G. (1998) · Medical Hypotheses · doi:10.1016/s0306-9877(98)90006-8 · Cited by 33
Molecular mechanisms of adipocyte differentiation
Ailhaud, G. P. (1997) · Journal of Endocrinology · doi:10.1677/joe.0.1550201 · Cited by 33
Measurement of testosterone and its sub-fractions in Canada
Lepage, R. (2005) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2005.10.014 · Cited by 33
Modulation of rat preadipocyte adipose conversion by androgenic status: involvement of C/EBPs transcription factors
Garcia, E., Lacasa, M., Agli, B., Giudicelli, Y., & Lacasa, D. (1999) · Journal of Endocrinology · doi:10.1677/joe.0.1610089 · Cited by 33
Permanent Induction of Morphological Abnormalities in the Penis and Penile Skeletal Muscles in Adult Rats Treated Neonatally With Diethylstilbestrol or Estradiol Valerate: A Dose‐Response Study
Goyal, H. O., Braden, T. D., Williams, C. S., Dalvi, P. S., Mansour, M. M., & Williams, J. W. (2005) · Journal of Andrology · doi:10.1002/j.1939-4640.2005.tb02869.x · Cited by 32
Weapons of penile smooth muscle destruction: Androgen deficiency promotes accumulation of adipocytes in the corpus cavernosum
Traish, A. M., & Kim, N. N. (2005) · The Aging Male · doi:10.1080/13685530500328183 · Cited by 32
Self-citation
Maturational and maintenance effects of testosterone on terminal axon density and neuropeptide expression in the rat vas deferens
Keast, J. R., Gleeson, R. J., Shulkes, A., & Morris, M. J. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00077-5 · Cited by 29
Hypogonadism and erectile dysfunction: pathophysiological observations and therapeutic outcomes
Morales, Á., & Heaton, J. (2003) · British Journal of Urology · doi:10.1111/j.1464-410x.2003.04532.x · Cited by 25
Molecular mechanisms of adipocyte differentiation.
Ed, R. (2002) · PubMed · Cited by 24
Effect of TCDD on corpus cavernosum histology and smooth muscle physiology
Moon, D. G., Lee, K., Kim, Y. W., Park, H. S., Cho, H. Y., & Kim, J. J. (2004) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901060 · Cited by 23
Androtest: a structured interview for the screening of hypogonadism in patients with sexual dysfunction
Corona, G., Petrone, L., Mannucci, E., Fisher, A. D., Chairini, V., Balercia, G., Forti, G., & Maggi, M. (2007) · 9th European Congress of Endocrinology · Cited by 22
Cabergoline treatment in men with psychogenic erectile dysfunction: a randomized, double-blind, placebo-controlled study
Nickel, M., Moleda, D., Loew, T. H., Rother, W. K., & Gil, F. P. (2006) · International Journal of Impotence Research · doi:10.1038/sj.ijir.3901483 · Cited by 21
Estradiol-17 β inhibition of androgen uptake, metabolism and binding in epididymis of adult male rats in vivo: A comparison with cyproterone acetate
Tindall, D. J., French, F. S., & Nayfeh, S. N. (1981) · Steroids · doi:10.1016/s0039-128x(81)90244-0 · Cited by 18
Relationship between gene expression of nitric oxide synthase and androgens in rat corpus cavernosum.
Shen, Z., Chen, Z., Lü, Y., Chen, F., & Chen, Z. (2000) · PubMed · Cited by 17
Mediation by the Androgen Receptor of the Stimulatory and Antiandrogenic Actions of 17β-Estradiol on the Growth of Androgen-Sensitive Shionogi Mammary Carcinoma Cells in Culture
Lüthy, I. A., BEGIN, D., & Labrie, F. (1988) · Endocrinology · doi:10.1210/endo-123-3-1418 · Cited by 16
Testosterone Treatment in Older Men: Effects on the Prostate
Morley, J. E. (2000) · Endocrine Practice · doi:10.4158/ep.6.2.218 · Cited by 15
Dehydroepiandrosterone Treatment in the Aging Male – What Should the Urologist Know?
Saad, F., Hoesl, C. E., Oettel, M., Fauteck, J., & Römmler, A. (2005) · European Urology · doi:10.1016/j.eururo.2005.06.020 · Cited by 14
Combined use of insulin and endothelin-1 causes decrease of protein expression of ?-subunit of insulin receptor, insulin receptor substrate-1, and insulin-stimulated glucose uptake in rat adipocytes
Shih, K., Kwok, C., & Ho, L.-T. (2000) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(20000801)78:2 · Cited by 13
Investigation, Treatment and Monitoring of Late-onset Hypogonadism
Schulman, C., & Kaufman, J. (2006) · touchREVIEWS in Endocrinology · doi:10.17925/ee.2006.00.02.1l · Cited by 13
Testosterone restores diabetes-induced erectile dysfunction and sildenafil responsiveness in two distinct animal models of chemical diabetes
Filippi, S., Morelli, A., Vignozzi, L., Zhang, X., Luconi, M., Donati, S., Forti, G., & Maggi, M. (2006) · 8th European Congress of Endocrinology incorporating the British Endocrine Societies · Cited by 11
[Ageing men's sexual functions decline and the erectile dysfunction (ED) increase].
Amar, E., Grivel, T., Hamidi, K., Lemaire, A., & Giuliano, F. (2005) · PubMed · Cited by 10
[Pharmacotherapy for erectile dysfunction].
Hu, W., & Hu, L. (2005) · PubMed · Cited by 9
Effect of Hypothyroidism on the NO/cGMP Pathway of Corpus Cavernosum in Rabbits
Kılıçarslan, H., Bağcıvan, İ., YILDIRIM, M. K., Saraç, B., & Kaya, T. (2006) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2006.00289.x · Cited by 8
Erectile dysfunction: molecular biology, pathophysiology and pharmacological treatment.
Morelli, A., Vignozzi, L., Filippi, S., Mancina, R., & Maggi, M. (2005) · PubMed · Cited by 7
Assays for complexed prostate-specific antigen and other advances in the diagnosis of prostate cancer.
Brawer, M. K. (2003) · PubMed · Cited by 6

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2 of the 184 references couldn’t be matched to a known paper.

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A Systematic Review of the Association Between Erectile Dysfunction and Cardiovascular Disease
Gandaglia, G., Briganti, A., Jackson, G., Kloner, R. A., Montorsi, F., Montorsi, P., & Vlachopoulos, C. V. (2013) · European Urology · doi:10.1016/j.eururo.2013.08.023 · Cited by 522
The role of estradiol in male reproductive function
Ramasamy, R., Schulster, M., & Bernie, A. (2016) · Asian Journal of Andrology · doi:10.4103/1008-682x.173932 · Cited by 411
Mechanisms of Penile Erection and Basis for Pharmacological Treatment of Erectile Dysfunction
Andersson, K. (2011) · Pharmacological Reviews · doi:10.1124/pr.111.004515 · Cited by 405
Low testosterone associated with obesity and the metabolic syndrome contributes to sexual dysfunction and cardiovascular disease risk in men with type 2 diabetes
Wang, C., Jackson, G., Jones, T. H., Matsumoto, A. M., Nehra, A., Perelman, M. A., Swerdloff, R. S., Traish, A., Zitzmann, M., & Cunningham, G. (2011) · Diabetes Care · doi:10.2337/dc10-2339 · Cited by 366
Self-citation
Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido and Erectile Dysfunction and Depression in a Subset of Patients
Traish, A. M., Hassani, J., Guay, A. T., Zitzmann, M., & Hansen, M. L. (2010) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2010.02157.x · Cited by 283
Self-citation

See all 268

Authors: Traish, A. M., Goldstein, I., & Kim, N. N.
Affiliations: Boston University (US)
Corresponding author: Traish, Abdulmaged M.
ORCID: Traish, Abdulmaged M.
Goldstein, Irwin
Kim, Noel N.
Venue: European Urology
Publisher: Elsevier BV
Published: 2007-07
Volume: 52
Issue: 1
Pages: 54-70
ISSN: 0302-2838 (ISSN-L)
DOI: 10.1016/j.eururo.2007.02.034
PMC: PMC2562639
OpenAlex: W2074489144
Cited by: 268
References: 184
Citations by year: 2026: 6 · 2025: 9 · 2024: 6 · 2023: 12 · 2022: 16 · 2021: 16 · 2020: 10 · 2019: 11 · 2018: 10 · 2017: 9 · 2016: 28 · 2015: 12 · 2014: 11 · 2013: 14 · 2012: 9
FWCI: 3.11
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: European Urology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK 56846, DK02696, K01DK002696, R01DK056846)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
Health Sciences › Medicine › Urology › Urological Disorders and Treatments
Keywords: testosterone, erectile dysfunction, androgen deficiency, erectile physiology, penile tissue, testosterone replacement therapy, male sexual health
MeSH terms: Androgens, Animals, Humans, Hypogonadism, Erectile Dysfunction, Male, Penile Erection, Testosterone

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Testosterone and Erectile Function: From Basic Research to a New Clinical Paradigm for Managing Men with Androgen Insufficiency and Erectile Dysfunction

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