Differences in Tumor VHL Mutation and Hypoxia-inducible Factor 2α Expression Between African American and White Patients with Clear Cell Renal Cell Carcinoma
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VHL gene mutations lead to stability of HIF subunits and constitutive activation of HIF-mediated transcriptional pathways in patients with VHL, causing progression of renal cell carcinoma.
“VHL gene mutations lead to the stability of HIF subunits and the constitutive activation of HIF‐mediated transcriptional pathways in patients with VHL, causing the progression of renal cell carcinoma.”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [25]
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Genetic basis of kidney cancer: Role of genomics for the development of disease-based therapeuticsPreprint
Linehan, W. M. (2012) · Genome Research · doi:10.1101/gr.131110.111 · Cited by 240 · see citing works
Self-citationHypertension and Risk of Renal Cell Carcinoma Among White and Black Americans
Colt, J. S., Schwartz, K., Graubard, B. I., Davis, F. G., Ruterbusch, J. J., DiGaetano, R., Purdue, M. P., Rothman, N., Wacholder, S., & Chow, W. (2011) · Epidemiology · doi:10.1097/ede.0b013e3182300720 · Cited by 143 · see citing works
Self-citationKrishnan, B., Rose, T. L., Kardos, J., Milowsky, M. I., & Kim, W. Y. (2016) · JAMA Oncology · doi:10.1001/jamaoncol.2016.0005 · Cited by 75 · see citing works
Racial disparity in outcomes of a clinical trial population with metastatic renal cell carcinoma
Tripathi, R., Heilbrun, L. K., Jain, V., & Vaishampayan, U. N. (2006) · Urology · doi:10.1016/j.urology.2006.02.036 · Cited by 47 · see citing works
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Hypoxia signaling in cancer: Implications for therapeutic interventions
Zhuang, Y., Liu, K., He, Q., Gu, X., Jiang, C., & Wu, J. (2023) · MedComm · doi:10.1002/mco2.203 · Cited by 119 · see citing works
- Authors
- Callahan, C. L., Moore, L., Lenz, P., Linehan, W. M., Nickerson, M. L., Rothman, N., & Purdue, M. P.
- Affiliations
- National Cancer Institute (US)
- Leidos Biomedical Research Inc. (United States) (US)
- Corresponding author
- Purdue, Mark P.
- Venue
- European Urology
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 75
- Issue
- 5
- Pages
- 882-884
- ISSN
- 0302-2838 (ISSN-L)
- PMC
- PMC8495471
- OpenAlex
- W2910995561
- Cited by
- 7
- References
- 4
- Citations by year
- 2025: 2 · 2024: 2 · 2023: 3
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- European Urology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Renal cell carcinoma treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Keywords
- clear cell renal cell carcinoma, von Hippel-Lindau gene, VHL mutation, HIF-2α, racial differences, African American patients, genetic susceptibility
- MeSH terms
- Endothelial PAS Domain-Containing Protein 1, Black or African American, Carcinoma, Renal Cell, Humans, Kidney Neoplasms, Mutation, White People, Basic Helix-Loop-Helix Proteins, Von Hippel-Lindau Tumor Suppressor Protein, Hypoxia-Inducible Factor 1, alpha Subunit
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