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Structure and function of the interphotoreceptor matrix surrounding retinal photoreceptor cells
Abstract
The interphotoreceptor matrix (IPM) is a highly organized structure with interconnected domains surrounding cone and rod photoreceptor cells and extends throughout the subretinal space. Based on known roles of the extracellular matrix in other tissues, the IPM is thought to have several prominent functions including serving as a receptor for growth factors, regulating retinoid transport, participating in cytoskeletal organization in surrounding cells, and regulation of oxygen and nutrient transport. In addition, a number of studies suggest that the IPM also may play a significant role in the etiology of retinal degenerative disorders. In this review, we describe the present knowledge concerning the structure and function of the IPM under physiological and pathological conditions.
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Oleic acid constitutes VLDL and is present in extracellular matrix in the eyes.
“oleic acid was used as it constitutes VLDL, and it is present in extracellular matrix in the eyes (22, 34).”
From ADAM17 mediates ectodomain shedding of the soluble VLDL receptor fragment in the retinal epithelium (2021) · cites this paper as [22]
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Metadata
- Authors
- Ishikawa, M., Sawada, Y., & Yoshitomi, T.
- Venue
- Experimental Eye Research
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 133
- Pages
- 3-18
- ISSN
- 0014-4835
- Cited by
- 153
- References
- 8
- Language
- en
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