The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Light-induced melatonin suppression: age-related reduction in response to short wavelength light
Abstract
One of the possible causes of disturbed circadian rhythms and sleep in the elderly may be impaired photic input to the circadian clock. Age-related changes in lens density are known to reduce the transmission of short wavelength light, which has been shown to be most effective in suppressing nocturnal melatonin. The aim of the study therefore was to investigate age-related changes in melatonin suppression in response to short and medium wavelength light. Young premenopausal (n=13) and postmenopausal (n=21) women were exposed to 30 min of monochromatic light at two different wavelengths and irradiances (lambda(max) 456 nm: 3.8 and 9.8 microW/cm(2); lambda(max) 548 nm: 28 and 62 microW/cm(2)). Melatonin suppression was compared across light treatments and between age groups. Significantly reduced melatonin suppression was noted in the elderly subjects following exposure to short wavelength (456 nm) light compared to the young subjects. These results are likely to reflect age-related changes in lens density.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Significantly reduced melatonin suppression was measured in the elderly subjects in response to exposure to blue (456 nm) light as compared to the young group.”
From The inner clock-Blue light sets the human rhythm (2019) · cites this paper as [48]
The cited source says what the claim attributes to it.
In the citing paper
“This finding is suggested to reflect the age‐related changes in lens density.”
From The inner clock-Blue light sets the human rhythm (2019) · cites this paper as [48]
In the citing paper
“There is substantial literature showing that environmental noise228,229 and light230–233 can adversely impact sleep and that neighborhoods that are active at night may directly impact sleep through these.”
From Sleep, Health, and Society (2017) · cites this paper as [233]
In the citing paper
“There is substantial literature showing that environmental noise228,229 and light230–233 can adversely impact sleep and that neighborhoods that are active at night may directly impact sleep through these.”
From Sleep, Health, and Society (2017) · cites this paper as [233]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Action Spectrum for Melatonin Regulation in Humans: Evidence for a Novel Circadian Photoreceptor
Brainard, G. C., Hanifin, J. P., Greeson, J. M., Byrne, B., Glickman, G., Gerner, E., & Rollag, M. D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-16-06405.2001 · Cited by 1,930
Thapan, K., Arendt, J., & Skene, D. J. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.t01-1-00261.x · Cited by 1,320
Spectral sensitivity of the foveal cone photopigments between 400 and 500 nm
Smith, V. C., & Pokorny, J. (1975) · Vision Research · doi:10.1016/0042-6989(75)90203-5 · Cited by 1,318
Sleep in Normal Aging and Dementia
Bliwise, D. L. (1993) · SLEEP · doi:10.1093/sleep/16.1.40 · Cited by 854
High Sensitivity of the Human Circadian Melatonin Rhythm to Resetting by Short Wavelength Light
Lockley, S. W., Brainard, G. C., & Czeisler, C. A. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-030570 · Cited by 782
Direct radioimmunoassay for melatonin in plasma.
Fraser, S., Cowen, P. J., Franklin, M., Franey, C. S., & Arendt, J. (1983) · Clinical Chemistry · doi:10.1093/clinchem/29.2.396 · Cited by 578
Pokorny, J., Smith, V. C., & Lutze, M. (1987) · Applied Optics · doi:10.1364/ao.26.001437 · Cited by 516
Indirect bright light improves circadian rest-activity rhythm disturbances in demented patients
Someren, E. J. W. V., Kessler, A., Mirmiran, M., & Swaab, D. F. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(97)89928-3 · Cited by 440
Spectral transmission of the human ocular media
Norren, D. V., & Vos, J. J. (1974) · Vision Research · doi:10.1016/0042-6989(74)90222-3 · Cited by 377
The Variation with Age of the Spectral Transmissivity of the Living Human Crystalline Lens
Said, F., & Weale, R. A. (2009) · Gerontologia · doi:10.1159/000210900 · Cited by 337
Cited by
Sorted by citations
Grandner, M. A. (2017) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2016.10.012 · Cited by 720
Haus, E. L., & Smolensky, M. H. (2013) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2012.08.003 · Cited by 499
Evidence‐Based Recommendations for the Assessment and Management of Sleep Disorders in Older Persons
Bloom, H. G., Ahmed, I., Alessi, C. A., Ancoli‐Israel, S., Buysse, D. J., Kryger, M. H., Phillips, B. A., Thorpy, M. J., Vitiello, M. V., & Zee, P. C. (2009) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02220.x · Cited by 464
The effects of light therapy on sleep problems: A systematic review and meta-analysis
van Maanen, A., Meijer, A. M., van der Heijden, K. B., & Oort, F. J. (2015) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2015.08.009 · Cited by 372
Duffy, J. F., Zitting, K.-M., & Chinoy, E. D. (2015) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2015.08.002 · Cited by 367
Metadata
- Authors
- HERLJEVIC, M., MIDDLETON, B., THAPAN, K., & SKENE, D.
- Affiliations
- University of Surrey (GB)
- Corresponding author
- SKENE, D
- ORCID
- Venue
- Experimental Gerontology
- Publisher
- Elsevier BV
- Published
- 2005-03
- Volume
- 40
- Issue
- 3
- Pages
- 237-242
- ISSN
- 0531-5565 (ISSN-L)
- OpenAlex
- W2050381923
- Cited by
- 169
- References
- 32
- Citations by year
- 2026: 8 · 2025: 7 · 2024: 8 · 2023: 5 · 2022: 8 · 2021: 12 · 2020: 5 · 2019: 8 · 2018: 7 · 2017: 11 · 2016: 10 · 2015: 5 · 2014: 9 · 2013: 6 · 2012: 8
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Experimental Gerontology (publishedVersion)
- PubMed (publishedVersion)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Physical Sciences › Environmental Science › Global and Planetary Change › Impact of Light on Environment and Health
- Keywords
- melatonin suppression, short-wavelength light, circadian rhythm, aging, lens density, postmenopausal women, sleep disorders, light irradiance, nocturnal melatonin
- MeSH terms
- Adult, Female, Humans, Melatonin, Middle Aged, Radiation, Postmenopause, Area Under Curve
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
