CoChat
Sign Up
Cited by 190

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Polyamine-rich food decreases age-associated pathology and mortality in aged mice

Soda, Kuniyasu, Dobashi, Yoh, Kano, Yoshihiko, Tsujinaka, Shingo, Konishi, Fumio·2009·Experimental Gerontology
DOI 10.1016/j.exger.2009.08.013
Open this paper in CoChat — free account

Abstract

The purpose of this study was to test whether oral intake of foods rich in polyamines (spermine and spermidine) suppresses age-associated pathology in aged mice. Synthetic polyamines were mixed into experimental chows, and 24-week-old Jc1:ICR male mice were fed one of three chows containing differing polyamine concentrations. The spermine and spermidine concentrations in the low, normal, and high polyamine chows were 143 and 224 nmol/g, 160 and 434 nmol/g, and 374 and 1540 nmol/g, respectively. An increase in concentration of polyamine in the blood was found only in mice fed the high polyamine chow at 50 weeks of age. While the body weights of mice in all three groups were similar, the survival rate of mice fed high polyamine chow was significantly higher than those in the other two groups (p=0.011). Mice fed the high polyamine chow analyzed at 88 weeks of age, corresponding to the end of the study, demonstrated lower incidence of glomerulosclerosis and increased expression of senescence marker protein-30 in both kidney and liver compared to those fed the low polyamine chow. As these pathological changes are associated with senescence, oral polyamine appears to inhibit the progression of age-associated pathologies.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.exger.2009.08.013

Cites

3 of 3 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 3 references

Research works printed but not linked: 35

  1. Anderson, 1986, Effects of aging on the renal glomerulus, Am. J. Med., 80, 435, 10.1016/0002-9343(86)90718-7 · DOI
  2. Bardocz, 1990, Luminal and basolateral polyamine uptake by rat small intestine stimulated to grow by Phaseolus vulgaris lectin phytohaemagglutinin in vivo, Biochim. Biophys. Acta, 1034, 46, 10.1016/0304-4165(90)90151-L · DOI
  3. Bardócz, 1993, Polyamines in food – implications for growth and health, J. Nutr. Biochem., 4, 66, 10.1016/0955-2863(93)90001-D · DOI
  4. Bardocz, 1995, The importance of dietary polyamines in cell regeneration and growth, Br. J. Nutr., 73, 819, 10.1079/BJN19950087 · DOI
  5. Bolton, 1980, Spontaneous glomerular sclerosis in aging Sprague–Dawley rats. II. Ultrastructural studies, Am. J. Pathol., 98, 339
  6. Childs, 2003, Polyamine-dependent gene expression, Cell. Mol. Life Sci., 60, 1394, 10.1007/s00018-003-2332-4 · DOI
  7. Clifford, 1995, Role of ornithine decarboxylase in epidermal tumorigenesis, Cancer Res., 55, 1680
  8. Das, 1982, Activity and modulation of ornithine decarboxylase and concentrations of polyamines in various tissues of rats as a function of age, Exp. Gerontol., 17, 95, 10.1016/0531-5565(82)90042-0 · DOI
  9. Demierre, 2005, Statins and cancer prevention, Nat. Rev. Cancer, 5, 930, 10.1038/nrc1751 · DOI
  10. Franceschi, 2000, Inflamm-aging. An evolutionary perspective on immunosenescence, Ann. NY Acad. Sci., 908, 244, 10.1111/j.1749-6632.2000.tb06651.x · DOI · Paper page
  11. Fujita, 1992, Purification of senescence marker protein-30 (SMP30) and its androgen-independent decrease with age in the rat liver, Biochim. Biophys. Acta, 1116, 122, 10.1016/0304-4165(92)90108-7 · DOI
  12. Hibshoosh, 1991, Effects of overexpression of ornithine decarboxylase (ODC) on growth control and oncogene-induced cell transformation, Oncogene, 6, 739
  13. Hu, 2002, Optimal diets for prevention of coronary heart disease, JAMA, 288, 2569, 10.1001/jama.288.20.2569 · DOI · Paper page
  14. Kano, 2007, Increased blood spermine levels decrease the cytotoxic activity of lymphokine-activated killer cells: a novel mechanism of cancer evasion, Cancer Immunol. Immunother., 56, 771, 10.1007/s00262-006-0229-4 · DOI
  15. Krauss, 1996, Dietary guidelines for healthy American adults. A statement for health professionals from the Nutrition Committee. American Heart Association, Circulation, 94, 1795, 10.1161/01.CIR.94.7.1795 · DOI
  16. Kutuzov, 2005, Regulation of apoptosis signal-regulating kinase 1 (ASK1) by polyamine levels via protein phosphatase 5, J. Biol. Chem., 280, 25388, 10.1074/jbc.M413202200 · DOI
  17. Morgan, 1998, Polyamines. An introduction, Methods Mol. Biol., 79, 3
  18. O’Brien, 1997, Ornithine decarboxylase overexpression is a sufficient condition for tumor promotion in mouse skin, Cancer Res., 57, 2630
  19. Okamoto, 1997, Polyamine content of ordinary foodstuffs and various fermented foods, Biosci. Biotechnol. Biochem., 61, 1582, 10.1271/bbb.61.1582 · DOI
  20. Papanikolaou, 2008, Bean consumption is associated with greater nutrient intake, reduced systolic blood pressure, lower body weight, and a smaller waist circumference in adults: results from the National Health and Nutrition Examination Survey 1999–2002, J. Am. Coll. Nutr., 27, 569, 10.1080/07315724.2008.10719740 · DOI
  21. Quemener, 1994, Polyamine deprivation: a new tool in cancer treatment, Anticancer Res., 14, 443
  22. Renaud, 2001, Coronary heart disease: dietary links and pathogenesis, Public Health Nutr., 4, 459, 10.1079/PHN2001134 · DOI
  23. Russell, 1983, Clinical relevance of polyamines, Crit. Rev. Clin. Lab. Sci., 18, 261
  24. Sarhan, 1992, Polyamine deprivation, malnutrition and tumor growth, Anticancer Res., 12, 457
  25. Sato, 2008, Hydrogen-rich pure water prevents superoxide formation in brain slices of vitamin C-depleted SMP30/GNL knockout mice, Biochem. Biophys. Res. Commun., 375, 346, 10.1016/j.bbrc.2008.08.020 · DOI
  26. Soda, 2005, Spermine, a natural polyamine, suppresses LFA-1 expression on human lymphocyte, J. Immunol., 175, 237, 10.4049/jimmunol.175.1.237 · DOI
  27. Soda, 2009, Long-term polyamine intake increases blood polyamine concentration, J. Nutr. Sci. Vitaminol., 55, 361, 10.3177/jnsv.55.361 · DOI
  28. Sousadias, 1995, Toxicity and growth-promoting potential of spermine when fed to chicks, J. Anim. Sci., 73, 2375, 10.2527/1995.7382375x · DOI
  29. Thomas, 2001, Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications, Cell. Mol. Life Sci., 58, 244, 10.1007/PL00000852 · DOI
  30. Til, 1997, Acute and subacute toxicity of tyramine, spermidine, spermine, putrescine and cadaverine in rats, Food Chem. Toxicol., 35, 337, 10.1016/S0278-6915(97)00121-X · DOI
  31. Uda, 2003, Rapid absorption of luminal polyamines in a rat small intestine ex vivo model, J. Gastroenterol. Hepatol., 18, 554, 10.1046/j.1440-1746.2003.03020.x · DOI
  32. Vasselli, 2005, Intentional weight loss reduces mortality rate in a rodent model of dietary obesity, Obes. Res., 13, 693, 10.1038/oby.2005.78 · DOI
  33. Wacholtz, 1989, Leukocyte function-associated antigen 1 is an activation molecule for human T cells, J. Exp. Med., 170, 431, 10.1084/jem.170.2.431 · DOI
  34. Wallace, 2003, A perspective of polyamine metabolism, Biochem. J., 376, 1, 10.1042/bj20031327 · DOI
  35. Williams, 1997, Interactions of polyamines with ion channels, Biochem. J., 325, 289, 10.1042/bj3250289 · DOI

Cited by

Sorted by citations

See all 190

Metadata

Authors
Soda, K., Dobashi, Y., Kano, Y., Tsujinaka, S., & Konishi, F.
Venue
Experimental Gerontology
Publisher
Elsevier BV
Published
2009-11
Volume
44
Issue
11
Pages
727-732
ISSN
0531-5565
DOI
10.1016/j.exger.2009.08.013
Cited by
190
References
3
Language
en
Licence

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Polyamine-rich food decreases age-associated pathology and mortality in aged mice. https://app.cochat.ai/papers/10.1016/j.exger.2009.08.013
The paper
Soda, K., Dobashi, Y., Kano, Y., Tsujinaka, S., & Konishi, F. (2009). Polyamine-rich food decreases age-associated pathology and mortality in aged mice. Experimental Gerontology. https://doi.org/10.1016/j.exger.2009.08.013