Spermidine in health and disease

The Hallmarks of Aging

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Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases

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Inflamm‐aging: An Evolutionary Perspective on Immunosenescence

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Resveratrol improves health and survival of mice on a high-calorie diet

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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Immunogenic cell death in cancer and infectious disease

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Extending Healthy Life Span—From Yeast to Humans

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Autophagy in Human Health and Disease

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Autophagy and Aging

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FoxO3 Controls Autophagy in Skeletal Muscle In Vivo

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Long-term weight loss maintenance

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Sirtuin activators mimic caloric restriction and delay ageing in metazoans

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Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

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Induction of autophagy by spermidine promotes longevity

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The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β

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mTOR regulates memory CD8 T-cell differentiation

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Enhancing CD8 T-cell memory by modulating fatty acid metabolism

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Immunological effects of conventional chemotherapy and targeted anticancer agents

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Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials

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Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

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Metformin improves healthspan and lifespan in mice

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Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

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Autophagy maintains stemness by preventing senescence

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Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

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Acetyl Coenzyme A: A Central Metabolite and Second Messenger

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NAD ⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice

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The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

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The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

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Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress

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Cardioprotection and lifespan extension by the natural polyamine spermidine

Eisenberg, T., Abdellatif, M., Schroeder, S., Primessnig, U., Stekovic, S., Pendl, T., Harger, A., Schipke, J., Zimmermann, A., Schmidt, A., et al. (2016) · Nature Medicine · doi:10.1038/nm.4222 · Cited by 1,168 · see citing works

Polyamines and cancer: old molecules, new understanding

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Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

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Metformin as a tool to target aging

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Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila Melanogaster

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Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan

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Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism

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Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

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Modulation of cellular function by polyamines

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Mammalian polyamine metabolism and function

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GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease

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Metabolic Control of Longevity

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The Ancient Drug Salicylate Directly Activates AMP-Activated Protein Kinase

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Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake

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Functions of Polyamines in Mammals

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Fasting Cycles Retard Growth of Tumors and Sensitize a Range of Cancer Cell Types to Chemotherapy

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Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells

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TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

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Rapamycin‐mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction

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PINK1/Parkin-mediated mitophagy in mammalian cells

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Association of Coffee Drinking with Total and Cause-Specific Mortality

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The GH/IGF-1 axis in ageing and longevity

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Polyamines: Natural and engineered abiotic and biotic stress tolerance in plants

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Caloric restriction mimetics enhance anticancer immunosurveillance

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Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

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Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

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Regulation of autophagy by cytosolic acetyl-coenzyme A

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Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome

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Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity

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Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1

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Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

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A dual role for autophagy in a murine model of lung cancer

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Metformin Inhibits Hepatic Mtorc1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex

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Engineered polyamine accumulation in tomato enhances phytonutrient content, juice quality, and vine life

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Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity

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The SIRT1 Activator SRT1720 Extends Lifespan and Improves Health of Mice Fed a Standard Diet

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SIRT1 Negatively Regulates the Mammalian Target of Rapamycin

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Increased monoamine oxidase b activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography

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Resveratrol Supplementation Does Not Improve Metabolic Function in Nonobese Women with Normal Glucose Tolerance

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Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43

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Restoring polyamines protects from age-induced memory impairment in an autophagy-dependent manner

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Rapamycin extends murine lifespan but has limited effects on aging

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Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan

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Autophagy is a critical regulator of memory CD8+ T cell formation

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Spermidine induces autophagy by inhibiting the acetyltransferase EP300

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Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice

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The Search for Antiaging Interventions: From Elixirs to Fasting Regimens

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Impact of intestinal microbiota on intestinal luminal metabolome

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Autophagy and neurodegeneration

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Reduced Levels of IGF-I Mediate Differential Protection of Normal and Cancer Cells in Response to Fasting and Improve Chemotherapeutic Index

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Spermine inhibits proinflammatory cytokine synthesis in human mononuclear cells: a counterregulatory mechanism that restrains the immune response

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Spermine and spermidine mediate protection against oxidative damage caused by hydrogen peroxide

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Polyamines and cancer: implications for chemotherapy and chemoprevention

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Metabolic Disturbances Identified in Plasma Are Associated With Outcomes in Patients With Heart Failure

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Rapamycin and Other Longevity-Promoting Compounds Enhance the Generation of Mouse Induced Pluripotent Stem Cells

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Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and Hepatocellular Carcinoma by Activating MAP1S-Mediated Autophagy

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The phytochemical, EGCG , extends lifespan by reducing liver and kidney function damage and improving age‐associated inflammation and oxidative stress in healthy rats

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Spermidine alleviates experimental autoimmune encephalomyelitis through inducing inhibitory macrophages

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Spermidine pretreatment enhances heat tolerance in rice seedlings through modulating antioxidative and glyoxalase systems

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Spermidine protects against α-synuclein neurotoxicity

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Macrophage PTEN Regulates Expression and Secretion of Arginase I Modulating Innate and Adaptive Immune Responses

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Modulation of cadmium toxicity and enhancing cadmium-tolerance in wheat seedlings by exogenous application of polyamines

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Protective effect of spermidine on salt stress induced oxidative damage in two Kentucky bluegrass (Poa pratensis L.) cultivars

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Lycibarbarspermidines A–O, New Dicaffeoylspermidine Derivatives from Wolfberry, with Activities against Alzheimer’s Disease and Oxidation

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Alzheimer's disease–like pathology has transient effects on the brain and blood metabolome

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Induction of autophagy by spermidine is neuroprotective via inhibition of caspase 3-mediated Beclin 1 cleavage

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Identification of a mammalian vesicular polyamine transporter

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Spermidine Suppresses Age-Associated Memory Impairment by Preventing Adverse Increase of Presynaptic Active Zone Size and Release

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The natural polyamines spermidine and spermine prevent bone loss through preferential disruption of osteoclastic activation in ovariectomized mice

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Spermidine promotes stress resistance in Drosophila melanogaster through autophagy-dependent and -independent pathways

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Increased Polyamine Intake Inhibits Age-Associated Alteration in Global DNA Methylation and 1,2-Dimethylhydrazine-Induced Tumorigenesis

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Polyamines-induced aluminum tolerance in mung bean: A study on antioxidant defense and methylglyoxal detoxification systems

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Spermidine ameliorates 3-nitropropionic acid (3-NP)-induced striatal toxicity: Possible role of oxidative stress, neuroinflammation, and neurotransmitters

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Spermidine alleviates the growth of saline-stressed ginseng seedlings through antioxidative defense system

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Reactivation of autophagy by spermidine ameliorates the myopathic defects of collagen VI-null mice

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Polyamines in biological samples: Rapid and robust quantification by solid-phase extraction online-coupled to liquid chromatography–tandem mass spectrometry

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Macrophage ABHD5 promotes colorectal cancer growth by suppressing spermidine production by SRM

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Spermidine reduces lipid accumulation and necrotic core formation in atherosclerotic plaques via induction of autophagy

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