An international effort to cure a global health problem: A report on the 19th Hemoglobin Switching Conference

Sickle Cell Anemia, a Molecular Disease

Pauling, L., Itano, H. A., Singer, S. J., & Wells, I. C. (1949) · Science · doi:10.1126/science.110.2865.543 · Cited by 2,319 · see citing works

Looping and Interaction between Hypersensitive Sites in the Active β-globin Locus

Tolhuis, B., Palstra, R.-J., Splinter, E., Grosveld, F., & de Laat, W. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00781-5 · Cited by 1,344 · see citing works

Therapeutic genome editing: prospects and challenges

Cox, D. B. T., Platt, R. J., & Zhang, F. (2015) · Nature Medicine · doi:10.1038/nm.3793 · Cited by 1,336 · see citing works

Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia

Cavazzana-Calvo, M., Payen, E., Negre, O., Wang, G., Hehir, K., Fusil, F., Down, J., Denaro, M., Brady, T., Westerman, K., et al. (2010) · Nature · doi:10.1038/nature09328 · Cited by 1,276 · see citing works

Genome-wide Identification of Polycomb-Associated RNAs by RIP-seq

Zhao, J. C., Ohsumi, T. K., Kung, J. T., Ogawa, Y., Grau, D., Sarma, K., Song, J. J., Kingston, R. E., Borowsky, M. L., & Lee, J. T. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.12.011 · Cited by 974 · see citing works

Human Fetal Hemoglobin Expression Is Regulated by the Developmental Stage-Specific Repressor <i>BCL11A</i>

Sankaran, V. G., Menne, T. F., Xu, J., Akie, T. E., Lettre, G., Van Handel, B., Mikkola, H. K. A., Hirschhorn, J. N., Cantor, A. B., & Orkin, S. H. (2008) · Science · doi:10.1126/science.1165409 · Cited by 919 · see citing works

Upstream Open Reading Frames as Regulators of mRNA Translation

Morris, D. R., & Geballe, A. P. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.23.8635-8642.2000 · Cited by 736 · see citing works

Controlling long-range genomic interactions at a native locus by targeted tethering of a looping factor

Deng, W., Lee, J., Wang, H., Miller, J., Reik, A., Gregory, P. D., Dean, A., & Blobel, G. A. (2012) · Cell · doi:10.1016/j.cell.2012.03.051 · Cited by 734 · see citing works

Long-range chromatin regulatory interactions in vivo

Carter, D., Chakalova, L., Osborne, C. S., Dai, Y.-F., & Fraser, P. (2002) · Nature Genetics · doi:10.1038/ng1051 · Cited by 663 · see citing works

An Erythroid Enhancer of <i>BCL11A</i> Subject to Genetic Variation Determines Fetal Hemoglobin Level

Bauer, D. E., Kamran, S. C., Lessard, S., Xu, J., Fujiwara, Y., Lin, C., Shao, Z., Canver, M. C., Smith, E. C., Pinello, L., et al. (2013) · Science · doi:10.1126/science.1242088 · Cited by 653 · see citing works

Transcription of antisense RNA leading to gene silencing and methylation as a novel cause of human genetic disease

Tufarelli, C., Stanley, J. A. S., Garrick, D., Sharpe, J. A., Ayyub, H., Wood, W. G., & Higgs, D. R. (2003) · Nature Genetics · doi:10.1038/ng1157 · Cited by 547 · see citing works

A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15

Menzel, S., Garner, C., Gut, I., Matsuda, F., Yamaguchi, M., Heath, S., Foglio, M., Zelenika, D., Boland, A., Rooks, H., et al. (2007) · Nature Genetics · doi:10.1038/ng2108 · Cited by 529 · see citing works

Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment

Hughes, J. R., Roberts, N., McGowan, S., Hay, D., Giannoulatou, E., Lynch, M., De Gobbi, M., Taylor, S., Gibbons, R., & Higgs, D. R. (2014) · Nature Genetics · doi:10.1038/ng.2871 · Cited by 461 · cited 1× · see citing works

Thalassaemia

Higgs, D. R., Engel, J. D., & Stamatoyannopoulos, G. (2011) · The Lancet · doi:10.1016/s0140-6736(11)60283-3 · Cited by 445 · see citing works

The effect of prolonged administration of hydroxyurea on morbidity and mortality in adult patients with sickle cell syndromes: results of a 17-year, single-center trial (LaSHS)

Voskaridou, E., Christoulas, D., Bilalis, A., Plata, E., Varvagiannis, K., Stamatopoulos, G., Sinopoulou, K., Balassopoulou, A., Loukopoulos, D., & Terpos, E. (2010) · Blood · doi:10.1182/blood-2009-05-221333 · Cited by 430 · see citing works

Identification of genetic elements that autonomously determine DNA methylation states

Lienert, F., Wirbelauer, C., Som, I., Dean, A., Mohn, F., & Schübeler, D. (2011) · Nature Genetics · doi:10.1038/ng.946 · Cited by 385 · see citing works

Developmental and species-divergent globin switching are driven by BCL11A

Sankaran, V. G., Xu, J., Ragoczy, T., Ippolito, G. C., Walkley, C. R., Maika, S. D., Fujiwara, Y., Ito, M., Groudine, M., Bender, M. A., et al. (2009) · Nature · doi:10.1038/nature08243 · Cited by 379 · see citing works

Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin

Borg, J., Papadopoulos, P., Georgitsi, M., Gutiérrez, L., Grech, G., Fanis, P., Phylactides, M., Verkerk, A. J. M. H., van der Spek, P. J., Scerri, C. A., et al. (2010) · Nature Genetics · doi:10.1038/ng.630 · Cited by 371 · see citing works

KLF1 regulates BCL11A expression and γ- to β-globin gene switching

Zhou, D., Liu, K., Sun, C.-W., Pawlik, K. M., & Townes, T. M. (2010) · Nature Genetics · doi:10.1038/ng.637 · Cited by 367 · see citing works

The Inheritance of Sickle Cell Anemia

Neel, J. V. (1949) · Science · doi:10.1126/science.110.2846.64 · Cited by 362 · see citing works

Transcriptional silencing of γ-globin by BCL11A involves long-range interactions and cooperation with SOX6

Xu, J., Sankaran, V. G., Ni, M., Menne, T. F., Puram, R. V., Kim, W., & Orkin, S. H. (2010) · Genes &amp; Development · doi:10.1101/gad.1897310 · Cited by 361 · see citing works

Discovering Hematopoietic Mechanisms through Genome-wide Analysis of GATA Factor Chromatin Occupancy

Fujiwara, T., O’Geen, H., Keleş, S., Blahnik, K. R., Linnemann, A. K., Kang, Y.-A., Choi, K., Farnham, P., & Bresnick, E. H. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.11.001 · Cited by 347 · see citing works

Developmental regulation of β-globin gene switching

Choi, O.-R., & Engel, J. D. (1988) · Cell · doi:10.1016/0092-8674(88)90005-0 · Cited by 308 · see citing works

Inhibition of translation in eukaryotic systems by harringtonine

FRESNO, M., JIMÉNEZ, A., & VÁZQUEZ, D. (1977) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1977.tb11256.x · Cited by 295 · see citing works

Mediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRAPreprint

Yao, H., Brick, K., Evrard, Y. A., Xiao, T., Camerini‐Otero, R. D., & Felsenfeld, G. (2010) · Genes & Development · doi:10.1101/gad.1967810 · Cited by 237 · see citing works

The hematopoietic stem compartment consists of a limited number of discrete stem cell subsets

Sieburg, H. B., Cho, R. H., Dykstra, B. J., Uchida, N., Eaves, C. J., & Müller‐Sieburg, C. E. (2005) · Blood · doi:10.1182/blood-2005-07-2970 · Cited by 236 · see citing works

Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A

Xu, J., Bauer, D. E., Kerenyi, M. A., Vo, T. D., Hou, S., Hsu, Y.-J., Yao, H., Trowbridge, J. J., Mandel, G., & Orkin, S. H. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303976110 · Cited by 233 · see citing works

Distinct Origins of Adult and Embryonic Blood in Xenopus

Ciau‐Uitz, A., Walmsley, M. E., & Patient, R. K. (2000) · Cell · doi:10.1016/s0092-8674(00)00067-2 · Cited by 228 · see citing works

Clinical experience with fetal hemoglobin induction therapy in patients with β-thalassemia

Musallam, K. M., Taher, A. T., Cappellini, M. D., & Sankaran, V. G. (2013) · Blood · doi:10.1182/blood-2012-10-408021 · Cited by 208 · see citing works

An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment

Lynch, M., Smith, A. J. H., Gobbi, M. D., Flenley, M., Hughes, J. R., Vernimmen, D., Ayyub, H., Sharpe, J. A., Sloane-Stanley, J. A., Sutherland, L., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.399 · Cited by 192 · see citing works

Pathophysiology and Clinical Manifestations of the -ThalassemiasPreprint

Nienhuis, A. W., & Nathan, D. G. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a011726 · Cited by 180 · see citing works

Distinct Mechanisms Control RNA Polymerase II Recruitment to a Tissue-Specific Locus Control Region and a Downstream Promoter

Johnson, K. D., Christensen, H. M., Zhao, B. M., & Bresnick, E. H. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00309-4 · Cited by 168 · see citing works

Newborn screening for hemoglobinopathies in California

Michlitsch, J., Azimi, M., Hoppe, C. C., Walters, M. C., Lubin, B. H., Lorey, F., & Vichinsky, E. P. (2008) · Pediatric Blood & Cancer · doi:10.1002/pbc.21883 · Cited by 164 · see citing works

HSP70 sequestration by free α-globin promotes ineffective erythropoiesis in β-thalassaemia

Arlet, J.-B., Ribeil, J.-A., Guillem, F., Negre, O., Hazoume, A., Marcion, G., Beuzard, Y., Dussiot, M., Moura, I. C., Demarest, S., et al. (2014) · Nature · doi:10.1038/nature13614 · Cited by 151 · see citing works

A single point mutation is the cause of the Greek form of hereditary persistence of fetal haemoglobin

Berry, M., Grosveld, F. G., & Dillon, N. (1992) · Nature · doi:10.1038/358499a0 · Cited by 142 · see citing works

The −117 mutation in Greek HPFH affects the binding of three nuclear factors to the CCAAT region of the gamma‐globin gene.

Superti‐Furga, G., Barberis, A., Schaffner, G., & Busslinger, M. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb03176.x · Cited by 130 · see citing works

Chicken “erythroid” cells transformed by the Gag-Myb-Ets-encoding E26 leukemia virus are multipotent

Graf, T., McNagny, K. M., Brady, G., & Frampton, J. (1992) · Cell · doi:10.1016/0092-8674(92)90096-u · Cited by 123 · see citing works

Characterisation of transcriptional networks in blood stem and progenitor cells using high-throughput single cell gene expression analysis

Moignard, V., Macaulay, I., Swiers, G., Buettner, F., Schütte, J., Calero-Nieto, F., Kinston, S., Joshi, A., Hannah, R., Theis, F. J., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2709 · Cited by 116 · see citing works

c-myb supports erythropoiesis through the transactivation of KLF1 and LMO2 expression

Bianchi, E., Zini, R., Salati, S., Tenedini, E., Norfo, R., Tagliafico, E., Manfredini, R., & Ferrari, S. (2010) · Blood · doi:10.1182/blood-2009-08-238311 · Cited by 115 · see citing works

An embryonic/fetal β‐type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer

Tanabe, O., Katsuoka, F., Campbell, A., Song, W., Yamamoto, M. P., Tanimoto, K., & Engel, J. D. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf340 · Cited by 113 · see citing works

Nuclear Receptors TR2 and TR4 Recruit Multiple Epigenetic Transcriptional Corepressors That Associate Specifically with the Embryonic β-Type Globin Promoters in Differentiated Adult Erythroid Cells

Cui, S., Kolodziej, K. E., Obara, N., Amaral-Psarris, A., Demmers, J., Shi, L., Engel, J. D., Grosveld, F. G., Strouboulis, J., & Tanabe, O. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05310-11 · Cited by 112 · see citing works

Mutations in Krüppel-like factor 1 cause transfusion-dependent hemolytic anemia and persistence of embryonic globin gene expression

Viprakasit, V., Ekwattanakit, S., Riolueang, S., Chalaow, N., Fisher, C. A., Lower, K. M., Kanno, H., Tachavanich, K., Bejrachandra, S., Saipin, J., et al. (2014) · Blood · doi:10.1182/blood-2013-09-526087 · Cited by 95 · see citing works

Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expression

Rank, G., Cerruti, L., Simpson, R. J., Moritz, R. L., Jane, S. M., & Zhao, Q. (2010) · Blood · doi:10.1182/blood-2009-10-251116 · Cited by 94 · see citing works

The BMP/BMPR/Smad pathway directs expression of the erythroid-specific EKLF and GATA1 transcription factors during embryoid body differentiation in serum-free media

Adelman, C. A., Chattopadhyay, S., & Bieker, J. J. (2002) · Development · doi:10.1242/dev.129.2.539 · Cited by 94 · see citing works

KLF1-null neonates display hydrops fetalis and a deranged erythroid transcriptome

Magor, G. W., Tallack, M. R., Gillinder, K. R., Bell, C. C., McCallum, N., Williams, B., & Perkins, A. C. (2015) · Blood · doi:10.1182/blood-2014-08-590968 · Cited by 92 · see citing works

A dynamic alternative splicing program regulates gene expression during terminal erythropoiesis

Pimentel, H., Parra, M., Gee, S. L., Ghanem, D., An, X., Li, J., Mohandas, N., Pachter, L. S., & Conboy, J. G. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1388 · Cited by 84 · see citing works

Dynamic shifts in occupancy by TAL1 are guided by GATA factors and drive large-scale reprogramming of gene expression during hematopoiesisPreprint

Wu, W.-S., Morrissey, C. S., Keller, C. A., Mishra, T., Pimkin, M., Blobel, G. A., Weiss, M. J., & Hardison, R. C. (2014) · Genome Research · doi:10.1101/gr.164830.113 · Cited by 82 · see citing works

GATA Motifs Regulate Early Hematopoietic Lineage-Specific Expression of the Gata2 Gene

Kobayashi‐Osaki, M., Ohneda, O., Suzuki, N., Minegishi, N., Yokomizo, T., Takahashi, S., Lim, K.-C., Engel, J. D., & Yamamoto, M. P. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.16.7005-7020.2005 · Cited by 75 · see citing works

Histones to the cytosol: exportin 7 is essential for normal terminal erythroid nuclear maturation

Hattangadi, S. M., Martínez-Morilla, S., Patterson, H. C., Shi, J., Burke, K. A., Figueroa, A. A., Venkatesan, S., Wang, J., Paulsen, K., Görlich, D., et al. (2014) · Blood · doi:10.1182/blood-2013-11-537761 · Cited by 71 · see citing works

Silencing of A γ-Globin Gene Expression during Adult Definitive Erythropoiesis Mediated by GATA-1-FOG-1-Mi2 Complex Binding at the −566 GATA Site

Harju-Baker, S., Costa, F. C., Fedosyuk, H., Neades, R. Y., & Peterson, K. R. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01858-07 · Cited by 65 · see citing works

Binding patterns of BCL11A in the globin and GATA1 loci and characterization of the BCL11A fetal hemoglobin locus

Jawaid, K., Wahlberg, K., Thein, S. L., & Best, S. (2010) · Blood Cells, Molecules, and Diseases · doi:10.1016/j.bcmd.2010.05.006 · Cited by 64 · see citing works

Activation of Eklf expression during hematopoiesis by Gata2 and Smad5 prior to erythroid commitment

Lohmann, F., & Bieker, J. J. (2008) · Development · doi:10.1242/dev.018200 · Cited by 58 · see citing works

Lymphomagenesis in SCID-X1 Mice Following Lentivirus-mediated Phenotype Correction Independent of Insertional Mutagenesis and γc Overexpression

Ginn, S. L., Liao, S. H. Y., Dane, A. P., Hu, M., Hyman, J., Finnie, J. W., Zheng, M., Cavazzana, M., Alexander, S. I., Thrasher, A. J., et al. (2010) · Molecular Therapy · doi:10.1038/mt.2010.50 · Cited by 58 · see citing works

Erythropoiesis and globin switching in compound Klf1::Bcl11a mutant mice

Esteghamat, F., Gillemans, N., Bilić, I., van den Akker, E., Cantú, I., van Gent, T., Klingmüller, U., van Lom, K., Lindern, M. V., Grosveld, F. G., et al. (2013) · Blood · doi:10.1182/blood-2012-06-434530 · Cited by 51 · see citing works

Lentiviral Vector Gene Therapy: Effective and Safe?

Persons, D. A. (2010) · Molecular Therapy · doi:10.1038/mt.2010.70 · Cited by 49 · see citing works

Hematopoietic Stem Cell Transplantation for Thalassemia

Gaziev, J., & Lucarelli, G. (2011) · Current Stem Cell Research & Therapy · doi:10.2174/157488811795495413 · Cited by 49 · see citing works

Recent Advances in β-Thalassemias

Cao, A., Moi, P., & Galanello, R. (2011) · Pediatric Reports · doi:10.4081/pr.2011.e17 · Cited by 44 · see citing works

A T-to-G Transversion at Nucleotide −567 Upstream of HBG2 in a GATA-1 Binding Motif Is Associated with Elevated Hemoglobin F

Chen, Z., Luo, H., Basran, R. K., Hsu, T.-H., Mang, D. W. H., Nuntakarn, L., Rosenfield, C. G., Patrinos, G. P., Hardison, R. C., Steinberg, M. H., et al. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00071-08 · Cited by 44 · see citing works

Allogeneic cellular gene therapy in hemoglobinopathies—evaluation of hematopoietic SCT in sickle cell anemia

Lucarelli, G. T., Gaziev, J., Isgrò, A., Sodani, P., Paciaroni, K., Alfieri, C., Angelis, G. D., Marziali, M., Simone, M. D., Gallucci, C., et al. (2011) · Bone Marrow Transplantation · doi:10.1038/bmt.2011.79 · Cited by 41 · see citing works

The emerging role of fetal hemoglobin induction in non-transfusion-dependent thalassemia

Thein, S. L. (2012) · Blood Reviews · doi:10.1016/s0268-960x(12)70011-5 · Cited by 41 · see citing works

Simvastatin and t-butylhydroquinone suppress KLF1 and BCL11A gene expression and additively increase fetal hemoglobin in primary human erythroid cells

Macari, E. R., Schaeffer, E. K., West, R. J., & Lowrey, C. H. (2012) · Blood · doi:10.1182/blood-2012-07-443986 · Cited by 40 · see citing works

TRIM28 is essential for erythroblast differentiation in the mouse

Hosoya, T., Clifford, M., Losson, R., Tanabe, O., & Engel, J. D. (2013) · Blood · doi:10.1182/blood-2013-04-496166 · Cited by 35 · see citing works

Differential GATA Factor Stabilities: Implications for Chromatin Occupancy by Structurally Similar Transcription Factors

Lurie, L. J., Boyer, M. E., Grass, J. A., & Bresnick, E. H. (2007) · Biochemistry · doi:10.1021/bi701692p · Cited by 35 · see citing works

Disruption of the Hbs1l-Myb Locus Causes Hereditary Persistence of Fetal Hemoglobin in a Mouse Model

Suzuki, M., Yamazaki, H., Mukai, H. Y., Motohashi, H., Shi, L., Tanabe, O., Engel, J. D., & Yamamoto, M. P. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01617-12 · Cited by 35 · see citing works

Adult Stage γ-Globin Silencing Is Mediated by a Promoter Direct Repeat Element

Omori, A., Tanabe, O., Engel, J. D., Fukamizu, A., & Tanimoto, K. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.9.3443-3451.2005 · Cited by 33 · see citing works

Chapter 5 Long‐Range Regulation of α‐Globin Gene Expression

Higgs, D. R., Vernimmen, D., & Wood, B. (2008) · Advances in genetics · doi:10.1016/s0065-2660(07)00005-3 · Cited by 32 · see citing works

Regulatory elements of the EKLF gene that direct erythroid cell-specific expression during mammalian development

Li, X., Chen, X., Chang, Y., & Bieker, J. J. (2004) · Blood · doi:10.1182/blood-2003-09-3231 · Cited by 28 · see citing works

PGC-1 Coactivator Activity Is Required for Murine Erythropoiesis

Cui, S., Tanabe, O., Lim, K.-C., Xu, H. E., Zhou, X. E., Lin, J. D., Shi, L., Schmidt, L. A., Campbell, A., Shimizu, R., et al. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.00247-14 · Cited by 26 · see citing works

Alternative options for DNA-based experimental therapy of β-thalassemia

Gambari, R. (2012) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2012.665047 · Cited by 22 · see citing works

DEK oncogene expression during normal hematopoiesis and in Acute Myeloid Leukemia (AML)

Logan, G. E., Mor‐Vaknin, N., Braunschweig, T. A., Jost, E., Schmidt, P. V., Markovitz, D. M., Mills, K., Kappes, F., & Percy, M. J. (2014) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2014.07.009 · Cited by 20 · see citing works

Tight Regulation of a Timed Nuclear Import Wave of EKLF by PKCθ and FOE during Pro-E to Baso-E Transition

Shyu, Y., Lee, T., Chen, X., Hsu, P., Wen, S.-C., Liaw, Y.-W., Lu, C.-H., Hsu, P.-Y., Lu, M., Hwang, J.-L., et al. (2014) · Developmental Cell · doi:10.1016/j.devcel.2014.01.007 · Cited by 19 · see citing works

DNA Methyltransferase Probing of Chromatin Structure Within Populations and on Single Molecules

Pardo, C., Hoose, S. A., Pondugula, S., & Kladde, M. P. (2009) · Methods in molecular biology · doi:10.1007/978-1-59745-190-1_4 · Cited by 11 · see citing works

Introduction

Porter, J. B. (2009) · Blood Reviews · doi:10.1016/s0268-960x(09)70002-5 · Cited by 2 · see citing works

Fetal hemoglobin in sickle cell anemia

Steinberg, M. H. (2020) · Blood · doi:10.1182/blood.2020007645 · Cited by 136 · see citing works

Reactivation of a developmentally silenced embryonic globin gene

King, A. J., Songdej, D., Downes, D. J., Beagrie, R. A., Liu, S., Buckley, M., Peng, H., Suciu, M., Oudelaar, A. M., Hanssen, L. L. P., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24402-3 · Cited by 53 · see citing works

HbE/β-Thalassemia and Oxidative Stress: The Key to Pathophysiological Mechanisms and Novel Therapeutics

Hirsch, R. E., Sibmooh, N., Fucharoen, S., & Friedman, J. M. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2016.6806 · Cited by 48 · see citing works

Potential new approaches to the management of the Hb Bart’s hydrops fetalis syndrome: the most severe form of α-thalassemia

King, A. J., & Higgs, D. R. (2018) · Hematology · doi:10.1182/asheducation-2018.1.353 · Cited by 33 · see citing works

Evolving treatment paradigms in sickle cell disease

Jagadeeswaran, R., & Rivers, A. E. (2017) · Hematology · doi:10.1182/asheducation-2017.1.440 · Cited by 26 · see citing works

When basic science reaches into rational therapeutic design: from historical to novel leads for the treatment of β-globinopathies

Andrieu‐Soler, C., & Soler, É. (2020) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000577 · Cited by 10 · see citing works

Control of fetal globin expression in man: new opportunities to challenge past discoveries

Papayannopoulou, T. (2020) · Experimental Hematology · doi:10.1016/j.exphem.2020.09.195 · Cited by 7 · see citing works

New therapeutic strategies for the treatment of β-hemoglobinopathies

Weber, L. (2018) · doi:10.70675/09314463zdfd1z46b4z9c0cz32c6c2c5ccc2

Rôle de l'histone désacétylase HDAC6 au cours de l'érythropoïèse humaine

Vong, P. (2022) · doi:10.70675/699e8d9bz5404z43f6zabe7zdd0f0b6c8c42

Abstracts of the 13 th Conference on Hemoglobin Switching Oxford, United Kingdom, September 26–30, 2002

(2003) · Blood Cells Molecules and Diseases · doi:10.1016/s1079-9796(03)00043-3

Abstracts from the 15th Conference on Hemoglobin Switching. September 14-18, 2006. Oxford, United Kingdom.

(2007) · PubMed

The 12th Conference on Hemoglobin Switching

(2000) · Blood Cells Molecules and Diseases · doi:10.1006/bcmd.2000.0326 · Cited by 2 · see citing works

De la globine à l’hématopoïèse : compte rendu de la 11e conférence « Hemoglobin switching »

Dusanter‐Fourt, I., Mignotte, V., Morlé, F., & Roméo, P. (1999) · Hématologie

From globine to hematopoïesis : 11th conference « Hemoglobin switching »

Dusanter‐Fourt, I., Mignotte, V., Morlé, F., & Roméo, P. (1999) · Hématologie