Inflammatory changes in the bone marrow microenvironment drive both niche and blood system remodeling during aging
Open accessIntegrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Pharmacological inhibition of IL-1 signaling resulted in recovery of the aged hematopoietic system from inflammatory (regenerative) stress.
“The pharmacological inhibition of IL-1 signaling resulted in recovery of the aged hematopoietic system from inflammatory (regenerative) stress.”
From Inflammatory bone marrow microenvironment (2019) · cites this paper as [47]
Recent single-cell studies on niche cells in young and aged mice demonstrated activation of inflammatory response programs, changes in osteoblastic differentiation, and metabolism with age, particularly through upregulation of IL1a/b.
“Recent single-cell studies on niche cells in young and aged mice demonstrated activation of inflammatory response programs, changes in osteoblastic differentiation, and also metabolism with age, in particular through upregulation of IL1a/b.47”
From Inflammatory bone marrow microenvironment (2019) · cites this paper as [47]
The inflammatory microenvironment in the old BM cavity drives remodeling of the niche and hematopoiesis, and blocking proinflammatory cytokines is instrumental in reverting aging of the BM niche and impaired regenerative potential of old HSCs.
“This study proposed that the inflammatory microenvironment in the old BM cavity drives remodeling of the niche and hematopoiesis.They proposed that blocking of proinflammatory cytokines is instrumental in reverting the aging of the BM niche and the impaired regenerative potential of old HSCs.”
From Inflammatory bone marrow microenvironment (2019) · cites this paper as [47]
Cited by
Sorted by citations
Inflammatory bone marrow microenvironment
Leimkühler, N. B., & Schneider, R. K. (2019) · Hematology · doi:10.1182/hematology.2019000045 · Cited by 82 · see citing works
“Recent single-cell studies on niche cells in young and aged mice demonstrated activation of inflammatory response programs, changes in osteoblastic differentiation, and also metabolism with age, in particular through upregulation of IL1a/b.(47) The pharmacological inhibition of IL-1 signaling resulted in recovery of t…”
BackgroundClonal Hematopoiesis, Cardiovascular Diseases and Hematopoietic Stem Cells
Kandarakov, O. F., & Belyavsky, A. V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217902 · Cited by 21 · see citing works
“In support of this hypothesis, the pro-inflammatory milieu in bone marrow of aged mice with hematological alterations reminiscent of those occurring with CH, induced changes not only in HSPCs but in their niches as well [90].”
BackgroundChimeric Antigen Receptor T-Cell Therapy and Hematopoiesis
Reinhardt, B., Lee, P. C., & Sasine, J. P. (2023) · Cells · doi:10.3390/cells12040531 · Cited by 8 · see citing works
Acute myeloid leukemia in elderly patients: New targets, new therapies
Park, H. J., & Gregory, M. A. (2023) · Aging and Cancer · doi:10.1002/aac2.12065 · Cited by 6 · see citing works
- Authors
- Verovskaya, E., Calero-Nieto, F., Reynaud, D., Zhang, S. Y., Herault, A., Bakker, S., Pietras, E., Svendsen, A. F., Wang, X., Kinston, S., Ho, T., Göttgens, B., & Passegue, E.
- Affiliations
- University of California, San Francisco (US)
- University of Cambridge (GB)
- ORCID
- Venue
- Experimental Hematology
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 64
- Pages
- S43-S44
- ISSN
- 0301-472X (ISSN-L)
- OpenAlex
- W2888026345
- Cited by
- 4
- References
- 0
- Citations by year
- 2023: 2 · 2020: 1 · 2019: 1
- FWCI
- 0.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Experimental Hematology (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
- Keywords
- bone marrow microenvironment, hematopoietic stem cells, aging, hematopoiesis, niche remodeling, inflammatory changes, HSC differentiation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
