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Subcortical Structures and Pathways Involved in Convulsive Seizure Generation

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The Midline Thalamus: Alterations and a Potential Role in Limbic Epilepsy

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MRI volumetry of the thalamus in temporal, extratemporal, and idiopathic generalized epilepsy

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Amygdaloid sclerosis in temporal lobe epilepsy

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Interaction of cortex and thalamus in spike and wave discharges of feline generalized penicillin epilepsy

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Temporal lobe epilepsy: Where do the seizures really begin?

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Mesial temporal lobe epilepsy: How do we improve surgical outcome?

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Functional Anatomy of Spontaneous Seizures in a Rat Model of Limbic Epilepsy

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Mediodorsal Thalamus Plays a Critical Role in the Development of Limbic Motor Seizures

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Thalamic excitation of hippocampal CA1 neurons: a comparison with the effects of CA3 stimulation

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Glucose and [ 11 C]flumazenil positron emission tomography abnormalities of thalamic nuclei in temporal lobe epilepsy

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Multiple roles of midline dorsal thalamic nuclei in induction and spread of limbic seizures

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Involvement of the Thalamocortical System in Epileptic Loss of Consciousness

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The Pathological Substrate of Limbic Epilepsy: Neuronal Loss in the Medial Dorsal Thalamic Nucleus as the Consistent Change

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Midline Thalamic Region: Widespread Excitatory Input to the Entorhinal Cortex and Amygdala

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Identification of a Median Thalamic System Regulating Seizures and Arousal

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Ontogeny and topography of seizure regulation by the substantia nigra

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Responses of Deep Entorhinal Cortex are Epileptiform in an Electrogenic Rat Model of Chronic Temporal Lobe Epilepsy

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Blockade of GABA receptors in superior colliculus protects against focally evoked limbic motor seizures

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Increased GABAergic inhibition in the midline thalamus affects signaling and seizure spread in the hippocampus-prefrontal cortex pathway

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Changes in midline thalamic recruiting responses in the prefrontal cortex of the rat during the development of chronic limbic seizures

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Aberrant neuronal physiology in the basal nucleus of the amygdala in a model of chronic limbic epilepsy

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Why does surgery fail to cure limbic epilepsy?

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Review: Hippocampal sclerosis in epilepsy: a neuropathology review

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An update for epilepsy research and antiepileptic drug development: Toward precise circuit therapy

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A sensitive and specific nanosensor for monitoring extracellular potassium levels in the brain

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Increased segregation of brain networks in focal epilepsy: An fMRI graph theory finding

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Expression of the Neuronal tRNA n-Tr20 Regulates Synaptic Transmission and Seizure Susceptibility

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Forecasting stroke-like episodes and outcomes in mitochondrial disease

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Role of the Fyn-PKCδ signaling in SE-induced neuroinflammation and epileptogenesis in experimental models of temporal lobe epilepsy

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Targeting brain and peripheral plasticity of the lipidome in acute kainic acid-induced epileptic seizures in mice via quantitative mass spectrometry

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Localization of epileptogenic zone based on graph analysis of stereo-EEG

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Glial source of nitric oxide in epileptogenesis: A target for disease modification in epilepsy

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Depression and Anxiety in the Epilepsies: from Bench to Bedside

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Frontal Lobe Epilepsy Alters Functional Connections Within the Brain's Motor Network: A Resting-State fMRI Study

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Antiepileptic Drug Combinations for Epilepsy: Mechanisms, Clinical Strategies, and Future Prospects

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Neuronal networks and energy bursts in epilepsy

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Hippocampal neuro-networks and dendritic spine perturbations in epileptogenesis are attenuated by neuroprotectin D1

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The epileptic amygdala: Toward the development of a neural prosthesis by temporally coded electrical stimulation

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The Endocannabinoid System Activation as a Neural Network Desynchronizing Mediator for Seizure Suppression

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Targeting prostaglandin receptor EP2 for adjunctive treatment of status epilepticus

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Vagus Nerve Stimulation Elicits Sleep EEG Desynchronization and Network Changes in Responder Patients in Epilepsy

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Abnormal Brain Areas Common to the Focal Epilepsies: Multivariate Pattern Analysis of fMRI

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Widespread EEG Changes Precede Focal Seizures

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Utility of Absolute Quantification in Non-lesional Extratemporal Lobe Epilepsy Using FDG PET/MR Imaging

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Metyrapone prevents brain damage induced by status epilepticus in the rat lithium-pilocarpine model

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An Overview of Non-drug Therapies for the Treatment of Epilepsy

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Involvement of Thalamus in Initiation of Epileptic Seizures Induced by Pilocarpine in Mice

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The medial pulvinar as a subcortical relay in temporal lobe status epilepticus

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Effective Connectivity of Hippocampal Neural Network and Its Alteration in Mg2+-Free Epilepsy Model

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Temporally unstructured electrical stimulation to the amygdala suppresses behavioral chronic seizures of the pilocarpine animal model

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Interactive effects of seizure frequency and lateralization on intratemporal effective connectivity in temporal lobe epilepsy

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Beyond the Epileptic Focus: Functional Epileptic Networks in Focal Epilepsy

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Nonperiodic stimulation for the treatment of refractory epilepsy: Applications, mechanisms, and novel insights

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Magnetic resonance imaging fingerprints of status epilepticus: A case–control study

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Earlier seizure onset and longer epilepsy duration correlate with the degree of temporal hypometabolism in patients with mesial temporal lobe sclerosis

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Seizure Control and Memory Impairment Are Related to Disrupted Brain Functional Integration in Temporal Lobe Epilepsy

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Lithium modulates the muscarinic facilitation of synaptic plasticity and theta-gamma coupling in the hippocampal-prefrontal pathway

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p53-Sensitive Epileptic Behavior and Inflammation in Ft1 Hypomorphic Mice

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Executive Function Performance for Children With Epilepsy Localized to the Frontal or Temporal Lobes

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Three-dimensionality shapes the dynamics of cortical interconnected to hippocampal networks

Brofiga, M., Pisano, M., Tedesco, M., Raiteri, R., & Massobrio, P. (2020) · Journal of Neural Engineering · doi:10.1088/1741-2552/abc023 · Cited by 17 · see citing works

Model-based asessment of an in-vivo predictive relationship from CA1 to CA3 in the rodent hippocampus

Sandler, R., Song, D. B., Hampson, R. E., Deadwyler, S. A., Berger, T. W., & Marmarelis, V. Z. (2014) · Journal of Computational Neuroscience · doi:10.1007/s10827-014-0530-8 · Cited by 16 · see citing works

Excitatory amino acid transporter 2 downregulation correlates with thalamic neuronal death following kainic acid‐induced status epilepticus in rat

Sakurai, M., Kurokawa, H., Shimada, A., Nakamura, K., Miyata, H., & MORITA, T. (2014) · Neuropathology · doi:10.1111/neup.12141 · Cited by 15 · see citing works

2014 Epilepsy Benchmarks Area I: Understanding the Causes of the Epilepsies and Epilepsy-Related Neurologic, Psychiatric, and Somatic Conditions

Caplan, R., Mefford, H. C., Berl, M. M., Chang, B. S., Lin, J. J., Mazarati, A. M., Fureman, B. E., & Dingledine, R. J. (2016) · Epiliepsy currents/Epilepsy currents · doi:10.5698/1535-7511-16.3.182 · Cited by 15 · see citing works

Epilepsy Benchmarks Area I: Understanding the Causes of the Epilepsies and Epilepsy-Related Neurologic, Psychiatric, and Somatic Conditions

Chang, B. S., Krishnan, V., Dulla, C. G., Jetté, N., Marsh, E. D., Dacks, P. A., Whittemore, V., & Poduri, A. (2020) · Epiliepsy currents/Epilepsy currents · doi:10.1177/1535759719895280 · Cited by 14 · see citing works

Nucleus accumbens shell: A potential target for drug-resistant epilepsy with neuropsychiatric disorders

Wang, J., Zhang, Y., Zhang, H., Wang, K., Wang, H., Qian, D., Qi, S., Yang, K., & Long, H. (2020) · Epilepsy Research · doi:10.1016/j.eplepsyres.2020.106365 · Cited by 11 · see citing works

Functional connectivity changes of nucleus Accumbens Shell portion in left mesial temporal lobe epilepsy patients

Yang, R., Zhao, X., Liu, J., Yao, X., Hou, F., Xu, Y., & Feng, Q. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-019-00217-1 · Cited by 10 · see citing works

Metabolic flux from the Krebs cycle to glutamate transmission tunes a neural brake on seizure onset

Jeong, J., Lee, J., Kim, J.-H., & Lim, C. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009871 · Cited by 9 · see citing works

A Magnetoencephalography Study of Pediatric Interictal Neuromagnetic Activity Changes and Brain Network Alterations Caused by Epilepsy in the High Frequency (80–1000 Hz)

Meng, L. (2019) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2019.2898683 · Cited by 9 · see citing works

A Deep Dive in the Involvement of the Cerebellum in Epilepsy: A Neuroanatomical and Cellular Approach

Rubio, C., Moreno, W., Ochoa, E., & Uribe, E. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867330666221028150138 · Cited by 8 · see citing works

Seizure Susceptibility Corrupts Inferior Colliculus Acoustic Integration

Pinto, H. P. P., Lucas, E. L. D. O., Carvalho, V. R., Mourão, F. A. G., Guarnieri, L. D. O., Mendes, E. M. A. M., Medeiros, D. D. C., & Moraes, M. F. D. (2019) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2019.00063 · Cited by 8 · see citing works

Alternate Seizure Spread with Agenesis of the Corpus Callosum

Velagapudi, L., Matias, C. M., Ambrose, T. M., Sperling, M. R., Nei, M., Wu, C., & Sharan, A. D. (2021) · Journal of Epilepsy Research · doi:10.14581/jer.21014 · Cited by 8 · see citing works

Combination of Matching Responsive Stimulations of Hippocampus and Subiculum for Effective Seizure Suppression in Temporal Lobe Epilepsy

Zhang, F., Yang, Y., Zheng, Y., Zhu, J., Wang, P., & Xu, K. (2021) · Frontiers in Neurology · doi:10.3389/fneur.2021.638795 · Cited by 8 · see citing works

A mathematical model of neuroimmune interactions in epileptogenesis for discovering treatment strategies

Batulin, D., Lagzi, F., Vezzani, A., Jedlička, P., & Triesch, J. (2022) · iScience · doi:10.1016/j.isci.2022.104343 · Cited by 8 · see citing works

Interaction between Thalamus and Hippocampus in Termination of Amygdala-Kindled Seizures in Mice

Zhang, Z., Li, J., Lu, Q.-C., Gong, H.-Q., Liang, P.-J., & Zhang, P.-M. (2016) · Computational and Mathematical Methods in Medicine · doi:10.1155/2016/9580724 · Cited by 8 · see citing works

Deep brain stimulation probing performance is enhanced by pairing stimulus with epileptic seizure

Medeiros, D. D. C., Raspante, L. B. D. P., Mourão, F. A. G., Carvalho, V. R., Mendes, E. M. A. M., & Moraes, M. F. D. (2018) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2018.09.048 · Cited by 8 · see citing works

Neuronal Networks in Epilepsy

Faingold, C. L., Raisinghani, M., & N’Gouemo, P. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-415804-7.00026-5 · Cited by 8 · see citing works

The potential mechanism of musicogenic epilepsy and future research avenues

Ellis, L. (2017) · Bioscience Horizons The International Journal of Student Research · doi:10.1093/biohorizons/hzx004 · Cited by 8 · see citing works

A new bio-inspired stimulator to suppress hyper-synchronized neural firing in a cortical network

Amiri, M., Amiri, M., Nazari, S., & Karim Faez, A. (2016) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2016.09.007 · Cited by 6 · see citing works

Data-Driven Network Dynamical Model of Rat Brains During Acute Ictogenesis

Tsukahara, V. H. B., Natal, J., Barth, V. B. D. O., de Oliveira, J. C., Cota, V. R., & Maciel, C. D. (2022) · Frontiers in Neural Circuits · doi:10.3389/fncir.2022.747910 · Cited by 6 · see citing works

Spatiotemporal expression patterns of genes coding for plasmalemmal chloride transporters and channels in neurological diseases

Huang, Y., Wang, Q., Peng, Y., Du, W., Wang, Q., Qi, J., Hao, Z., & Wang, Y. (2023) · Molecular Brain · doi:10.1186/s13041-023-01018-w · Cited by 5 · see citing works

Persistent alterations in seizure susceptibility, drug responsiveness and comorbidities associated with chemical kindling after neonatal exposure to an organophosphate

Alipour, V., Hoseinpour, F., & Vatanparast, J. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.03.002 · Cited by 5 · see citing works

Electrophysiology in epilepsy surgery: Roles and limitations

Bertram, E. H. (2014) · Annals of Indian Academy of Neurology · doi:10.4103/0972-2327.128649 · Cited by 5 · see citing works

Rapid chain generation of interpostsynaptic functional LINKs can trigger seizure generation: Evidence for potential interconnections from pathology to behavior

Vadakkan, K. I. (2016) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2016.03.014 · Cited by 6 · see citing works

Distribution of NECAB1-Positive Neurons in Normal and Epileptic Brain—Expression Changes in Temporal Lobe Epilepsy and Modulation by Levetiracetam and Brivaracetam

Kelemen, K., Orbán-Kis, K., Szentes, Á., Nagy, Z., Kelemen, H., Fehér, A., Bába, L.-I., Gáll, Z., Horváth, E., Katona, I., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26104906 · Cited by 4 · see citing works

A multiplier-less digital design of a bio-inspired stimulator to suppress synchronized regime in a large-scale, sparsely connected neural network

Nazari, S., Karim Faez, A., & Amiri, M. (2015) · Neural Computing and Applications · doi:10.1007/s00521-015-2071-0 · Cited by 3 · see citing works

Surgical alternatives for the control of epileptic seizures

Rubio, C., Taddei, E., Custodio, V., & Paz, C. (2019) · Neurology and Neurosurgery · doi:10.15761/nns.1000126 · Cited by 3 · see citing works

Inhibition of the glutamatergic PVT-NAc projections attenuates local anesthetic-induced neurotoxic behaviors

Zou, Y., He, X., Ye, Z., Li, Z., Guo, Q., Zou, W., & Peng, Q. (2024) · Regional Anesthesia & Pain Medicine · doi:10.1136/rapm-2023-104964 · Cited by 2 · see citing works

Compartmental neuronal degeneration in the ventral striatum induced by status epilepticus in young rats' brain in comparison with adults

Al‐Redouan, A., Salaj, M., Kubová, H., & Druga, R. (2024) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10331 · Cited by 2 · see citing works

Prevalence of seizures in thalamic brain tumour, a single centre experience and a meta-analysis

Choon, X.-Y., Al-Nuaimy, Y., Lee, J. M.-C., Audrey, C., Fong, S., Lim, K. S., Narayanan, V., & Tan, C. T. (2023) · Brain Disorders · doi:10.1016/j.dscb.2023.100083 · Cited by 1 · see citing works

Distinct Patterns of Temporally Coded Electrical Stimulation Interfere With Long-Range Interhemispheric Coupling in a Focal Model of Epilepsy

Xavier, L. R., Montalvão, T. M. M., Guarnieri, L. D. O., Carvalho‐Moreira, J. P., Passos, M. C., Cota, V. R., & Moraes, M. F. D. (2025) · Neuromodulation Technology at the Neural Interface · doi:10.1016/j.neurom.2025.08.414 · Cited by 1 · see citing works

Patterns of Postictal Abnormalities in Relation to Status Epilepticus in Adults

Bolle, A. E., Sarria‐Estrada, S., Bonduelle, T., Dynesen, B. D., Toledo, M., Che, Z. C., Heuser, K., Chatzikonstantinou, A., Aupy, J., Seneviratne, U. K., et al. (2025) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.70295 · Cited by 1 · see citing works

Transparent Transfer‐Free Ultrasmall Multilayer Graphene Microelectrodes Enable High Quality Recordings in Brain Slices

de Eulate, N. A., Pavlou, C., González, G. L., Camarena, M., Holzapfel, L., Gao, Z., Vollebregt, S., & Giagka, V. (2026) · Advanced Science · doi:10.1002/advs.202517524 · Cited by 1 · see citing works

Detection of early seizures by diffuse optical tomography

Zhang, T., Hajihashemi, M. R., Zhou, J., Carney, P. R., & Jiang, H. (2015) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.2075409 · Cited by 1 · see citing works

Are Absence and Limbic Seizures Mutually Exclusive?: An Experimental Approach to Enigmatic Clinical Concept

Onat, F., & Eşkazan, E. (2021) · Journal of Pediatric Epilepsy · doi:10.1055/s-0041-1722870 · Cited by 1 · see citing works

Bcl-2 and caspase-9 serum levels in children and adolescents with idiopathic epilepsy and active seizures

SKARDOUTSOU, A., PRIMIKIRIS, P., TSENTIDIS, C., MARMARINOS, A., & GOURGIOTIS, D. (2022) · Minerva Pediatrics · doi:10.23736/s2724-5276.17.04787-9 · Cited by 1 · see citing works

A model for the evolution of the neuronal network in kindled brain slices

Mishra, N., Karan, R., Biswal, B., & Singh, H. P. (2018) · Physica A Statistical Mechanics and its Applications · doi:10.1016/j.physa.2018.03.098 · Cited by 1 · see citing works

Do the Dento-Thalamic Connections of Genetic Absence Epilepsy Rats from Strasbourg Differ from Those of Control Wistar Rats?

Bay, H. H., Özkan, M., Onat, F., & Çavdar, S. (2019) · Brain Connectivity · doi:10.1089/brain.2019.0694 · Cited by 1 · see citing works

Dataset of long-term multi-site LFP activity with spontaneous chronic seizures in temporal lobe epilepsy rats

Ni, H., Yang, Y., Zhang, F., Sun, Y., Zheng, Y., Zhu, J., & Xu, K. (2025) · Scientific Data · doi:10.1038/s41597-025-05023-7 · Cited by 1 · see citing works

Chimera states in hybrid coupled neuron populations

Çalım, A., Torres, J. J., Özer, M., & Uzuntarla, M. (2020) · Neural Networks · doi:10.1016/j.neunet.2020.03.002

Special Issue on Epilepsy

Carney, P. R. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.04.006

Molecular Targets on Antiepileptogenic Therapy Research: Deconstructing the Network for Translational Purposes

Freire‐Cobo, C. (2015) · Pharmacy & Pharmacology International Journal · doi:10.15406/ppij.2015.02.00018

Ratio Ictal SPECT Co-registered with MRI visualizes a greater extent of the ictal onset zone in focal refractory epilepsy

Jain, M. (2016) · Journal of Medical Science And clinical Research · doi:10.18535/jmscr/v4i5.33

Studies of the N-end Rule Pathway in Bacteria and Mammals

Vu, T. M. T. (2016) · CaltechTHESIS (California Institute of Technology) · doi:10.7907/z9668b5j

The Development of Propagated Discharge and Behavioural Arrest in Temporal Lobe Focal Seizures with Impairment of Awareness

Mohamed, J. (2018) · TSpace (University of Toronto)

Devices used for Treatment of Epilepsy

Alam, M. N., Jain, J., Khan, A. D., Kaushik, R., Khan, N. A., & Singh, L. (2020) · INTERNATIONAL JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH (IJPER) · doi:10.37021/ijper.v2i2.5

Central Histaminergic Signaling, Neural Excitability and EpilepsyPreprint

Yang, L. C., Wang, Y., & Chen, Z. (2020) · doi:10.22541/au.160937136.67710116/v1

A phenomenological model of neuroimmune interactions in epileptogenesisPreprint

Batulin, D., Lagzi, F., Vezzani, A., Jedlička, P., & Triesch, J. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.30.454477

A Mathematical Model of Neuroimmune Interactions in Epileptogenesis: A New Tool for Discovering Treatment Strategies In SilicoPreprint

Batulin, D., Lagzi, F., Vezzani, A., Jedlička, P., & Triesch, J. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3910799

Focal trigger zones and pathways of propagation in seizure generation

Gale, K. (1993) · Epilepsy · doi:10.1017/cbo9780511663314.004 · Cited by 17 · see citing works

Epileptic Seizures: Glia–Neuron Interactions For Better or For Worse

Rosch, R. E., & Samarut, É. (2019) · Current Biology · doi:10.1016/j.cub.2019.10.015 · Cited by 8 · see citing works

Connectivity and Excitability Shape Seizure Circuits

Brodovskaya, A., & Kapur, J. (2022) · Epiliepsy currents/Epilepsy currents · doi:10.1177/15357597221136961 · Cited by 4 · see citing works

Reviewed by:

Neubauer, F. B., Sederberg, A., MacLean, J. N., Traub, R. D., Health, S., Adams, N. E., & Neubauer, F. B. (2014)

Microcircuits and their interactions in epilepsy: is the focus out of focus?

Paz, J. T., & Huguenard, J. R. (2015) · Nature Neuroscience · doi:10.1038/nn.3950 · Cited by 321 · see citing works