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Cited by 124Aluminum toxicity and tolerance in plants and animalsCarcinogens and Genotoxicity AssessmentBee Products Chemical Analysis

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Propolis prevents aluminium-induced genetic and hepatic damages in rat liver

Türkez, Hasan, Yousef, Mokhtar I., Geyikoglu, Fatime·2010·Food and Chemical Toxicology
DOI 10.1016/j.fct.2010.06.049
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Abstract

Aluminium is present in several manufactured foods and medicines and is also used in water purification. Therefore, the present experiment was undertaken to determine the effectiveness of propolis in modulating the aluminium chloride (AlCl(3)) induced genotoxicity and hepatotoxicity in liver of rats. Animals were assigned to 1 of 4 groups: control; 34 mg AlCl(3)/kg bw; 50mg propolis/kg bw; AlCl(3) (34 mg/kg bw) plus propolis (50mg/kg bw), respectively. Rats were orally administered their respective doses daily for 30 days. At the end of the experiment, rats were anesthetized and hepatocytes (HEP) were isolated for counting the number of micronucleated hepatocytes (MNHEPs). In addition, the levels of serum enzymes and histological alterations in liver were investigated. AlCl(3) caused a significant increase in MNHEPs, alkaline phosphatase, transaminases (AST and ALT) and lactate dehydrogenase (LDH). Furthermore, severe pathological damages such as: sinusoidal dilatation, congestion of central vein, lipid accumulation and lymphocyte infiltration were established in liver. On the contrary, treatment with propolis alone did not cause any adverse effect on above parameters. Moreover, simultaneous treatments with propolis significantly modulated the toxic effects of AlCl(3). It can be concluded that propolis has beneficial influences and could be able to antagonize AlCl(3) toxicity.

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  • Propolis prevented genetic and hepatic damages induced by Al intoxication.

    “Türkez et al. (2010) reported that propolis prevented the genetic and hepatic damages induced by Al intoxication.”

    From Aluminium toxicosis: a review of toxic actions and effects (2019) · cites this paper as Türkez et al., 2010

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Metadata

Authors
Türkez, H., Yousef, M. I., & Geyikoglu, F.
Affiliations
  • Atatürk University (TR)
  • Alexandria University (EG)
Corresponding author
Yousef, Mokhtar I.
ORCID
Venue
Food and Chemical Toxicology
Publisher
Elsevier BV
Published
2010-10
Volume
48
Issue
10
Pages
2741-2746
ISSN
0278-6915 (ISSN-L)
DOI
10.1016/j.fct.2010.06.049
OpenAlex
W1965983315
Cited by
124
References
0
Citations by year
2026: 1 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 7 · 2021: 5 · 2020: 13 · 2019: 10 · 2018: 7 · 2017: 13 · 2016: 12 · 2015: 6 · 2014: 8 · 2013: 8 · 2012: 14
FWCI
10.74
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Food and Chemical Toxicology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ataturk University (2007-161)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Carcinogens and Genotoxicity Assessment
  • Life Sciences › Agricultural and Biological Sciences › Insect Science › Bee Products Chemical Analysis
Keywords
propolis, aluminum chloride, genotoxicity, hepatotoxicity, micronuclei, liver histopathology, transaminases, alkaline phosphatase, lactate dehydrogenase, hepatoprotection, metal toxicity
MeSH terms
Aluminum Chloride, Alanine Transaminase, Alkaline Phosphatase, Animals, Aspartate Aminotransferases, Chlorides, L-Lactate Dehydrogenase, Liver, Liver Function Tests, Male, Propolis, Micronucleus Tests, Antimutagenic Agents, Rats, Sprague-Dawley, Aluminum Compounds, Oxidative Stress, Hepatocytes, Rats, Chemical and Drug Induced Liver Injury

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