Cited by 228Cholesterol and Lipid MetabolismAntioxidant Activity and Oxidative StressSteroid Chemistry and Biochemistry

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Oxysterols: A world to explore

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Otaegui-Arrazola, A., Menéndez-Carreño, M., Ansorena, D., Astiasarán, I.·2010·Food and Chemical Toxicology

DOI 10.1016/j.fct.2010.09.023

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Abstract

Oxysterols (oxidized derivatives of cholesterol and phytosterols) can be generated in the human organism through different oxidation processes, some requiring enzymes. Furthermore, oxysterols are also present in food due to lipid oxidation reactions caused by heating treatments, contact with oxygen, exposure to sunlight, etc., and they could be absorbed from the diet, at different rates depending on their side chain length. In the organism, oxysterols can follow different routes: secreted into the intestinal lumen, esterified and distributed by lipoproteins to different tissues or degraded, mainly in the liver. Cholesterol oxidation products (COPs) have shown cytotoxicity, apoptotic and pro-inflammatory effects and they have also been linked with chronic diseases including atherosclerotic and neurodegenerative processess. In the case of phytosterol oxidation products (POPs), more research is needed on toxic effects. Nevertheless, current knowledge suggests they may also cause cytotoxic and pro-apoptotic effects, although at higher concentrations than COPs. Recently, new beneficial biological activities of oxysterols are being investigated. Whereas COPs are associated with cholesterol homeostasis mediated by different mechanisms, the implication of POPs is not clear yet. Available literature on sources of oxysterols in the organism, metabolism, toxicity and potential beneficial effects of these compounds are reviewed in this paper.

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Authors: Otaegui-Arrazola, A., Menéndez-Carreño, M., Ansorena, D., & Astiasarán, I.
Affiliations: Universidad de Navarra (ES)
Corresponding author: Ansorena, D.
ORCID: Ansorena, D.
Astiasarán, I.
Venue: Food and Chemical Toxicology
Publisher: Elsevier BV
Published: 2010-12
Volume: 48
Issue: 12
Pages: 3289-3303
ISSN: 0278-6915 (ISSN-L)
DOI: 10.1016/j.fct.2010.09.023
OpenAlex: W2032429163
Cited by: 228
References: 170
Citations by year: 2026: 4 · 2025: 3 · 2024: 9 · 2023: 8 · 2022: 5 · 2021: 12 · 2020: 16 · 2019: 12 · 2018: 10 · 2017: 21 · 2016: 17 · 2015: 39 · 2014: 17 · 2013: 24 · 2012: 21
FWCI: 3.13
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Food and Chemical Toxicology (publishedVersion)
PubMed (publishedVersion)
Deposito Adademico Digital Universidad De Navarra (University of Navarra) (submittedVersion, other-oa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Physical Sciences › Chemistry › Organic Chemistry › Steroid Chemistry and Biochemistry
Keywords: oxysterols, cholesterol oxidation products, phytosterol oxidation products, cholesterol metabolism, cytotoxicity, apoptosis, pro-inflammatory effects, atherosclerosis, neurodegenerative diseases, cholesterol homeostasis, lipid oxidation
MeSH terms: Animals, Cholesterol, Diet, Food Analysis, Humans, Oxidation-Reduction, Phytosterols, Sterols, Atherosclerosis

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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Oxysterols: A world to explore

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

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