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Cited by 319

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Oxysterol biosynthetic enzymes

Russell, D·2000·Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
DOI 10.1016/s1388-1981(00)00142-6
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Abstract

Oxysterols, herein defined as derivatives of cholesterol with a hydroxyl group on the side chain, play several roles in lipid metabolism. Members of this class regulate the expression of genes that participate in both sterol and fat metabolism, serve as substrates for the synthesis of bile acids, and are intermediates in the transfer of sterols from the periphery to the liver. Three abundant naturally occurring oxysterols are 24-hydroxycholesterol, 25-hydroxycholesterol, and 27-hydroxycholesterol. The cholesterol hydroxylase enzymes that synthesize each of these have been isolated over the last several years and their study has produced insight into the biology of oxysterols. This article focuses on the properties of these enzymes.

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Crossref · 10.1016/s1388-1981(00)00142-6

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2 of 2 references verified0 citation errors · 0 not checkable

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  • 25-Hydroxycholesterol is converted from cholesterol by the oxidoreductase cholesterol 25-hydroxylase (CH25H).

    “It is converted from cholesterol by the oxidoreductase cholesterol 25-hydroxylase (CH25H) [47, 48], an enzyme highly expressed and induced primarily in peripheral macrophages and dendritic cells in response to inflammatory stimuli like LPS and interferon [49, 50].”

    From 25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner (2020) · cites this paper as [48]

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Metadata

Authors
Russell, D.
Venue
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Publisher
Elsevier BV
Published
2000-12-15
Volume
1529
Issue
1-3
Pages
126-135
ISSN
1388-1981
DOI
10.1016/s1388-1981(00)00142-6
Cited by
319
References
2
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)

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