Chemopreventive effects of standardized ethanol extract from the aerial parts of Artemisia princeps Pampanini cv. Sajabal via NF-κB inactivation on colitis-associated colon tumorigenesis in mice
Abstract
Chronic inflammation is an underlying risk factor of colon cancer, and NF-κB plays a critical role in the development of inflammation-associated colon cancer in an AOM/DSS mouse model. The aim of this study was to determine whether the standardized ethanol extract obtained from the aerial parts of Artemisia princeps Pampanini cv. Sajabal (EAPP) is effective at preventing inflammation-associated colon cancer, and if so, to identify the signaling pathways involved. In the present study, protective efficacy of EAPP on tumor formation and the infiltrations of monocytes and macrophages in colons of an AOM/DSS mouse model were evaluated. It was found that colitis and tumor burdens showed statistically meaningful improvements after EAPP administration. Furthermore, these improvements were accompanied by a reduction in NF-κB activity and in the levels of NF-κB-dependent pro-survival proteins, that is, survivin, cFLIP, XIAP, and Bcl-2. In vitro, EAPP significantly reduced NF-κB activation and the levels of IL-1β and IL-8 mRNA and pro-survival proteins in HT-29 and HCT-116 colon cancer cells. Furthermore, EAPP caused caspase-dependent apoptosis. Based on these results, the authors suggest EAPP suppresses inflammatory responses and induces apoptosis partly via NF-κB inactivation, and that EAPP could be useful for the prevention of colitis-associated tumorigenesis.
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Artemisia princeps extract (APE) has anti-inflammatory and antioxidant effects.
“The Japanese mugwort, Artemisia princeps (yomogi in Japanese), has anti-inflammatory and antioxidant effects.”
From Antioxidant Artemisia princeps Extract Enhances the Expression of Filaggrin and Loricrin via the AHR/OVOL1 Pathway (2017) · cites this paper as [1]
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- Authors
- Chung, K.-S., Choi, H.-E., Shin, J.-S., Cho, E.-J., Cho, Y.-W., Choi, J.-H., Baek, N.-I., & Lee, K.-T.
- Affiliations
- Kyung Hee University (KR)
- Venue
- Food and Chemical Toxicology
- Publisher
- Elsevier BV
- Published
- 2015-01
- Volume
- 75
- Pages
- 14-23
- ISSN
- 0278-6915 (ISSN-L)
- OpenAlex
- W2024298211
- Cited by
- 14
- References
- 63
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2018: 2 · 2017: 3 · 2016: 2
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Food and Chemical Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Science and Technology (2011-0023407)
- National Research Foundation of Korea
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
- Keywords
- Artemisia princeps, ethanol extract, colitis-associated colorectal cancer, NF-κB signaling, chemoprevention, AOM/DSS model, chronic inflammation, apoptosis, caspase-dependent apoptosis, pro-survival proteins, survivin, IL-1β, interleukin-8, macrophage infiltration, colon cancer
- MeSH terms
- Animals, Colitis, Colonic Neoplasms, Humans, Macrophages, Male, Mice, Inbred ICR, Monocytes, Plant Extracts, RNA, Messenger, Interleukin-8, NF-kappa B, Anticarcinogenic Agents, Apoptosis, HT29 Cells, Artemisia, Plant Components, Aerial, HCT116 Cells, Mice, Interleukin-1beta, Carcinogenesis
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