The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
ABCG2 – a transporter for all seasons
Abstract
The human ABCG2 (ABCP/MXR/BCRP) protein is a recently recognized ABC half‐transporter, which forms homodimers in the plasma membrane and actively extrudes a wide variety of chemically unrelated compounds from the cells. This protein protects our cells and tissues against various xenobiotics, with a crucial role in the intestine, liver, placenta, and the blood–brain barrier. Moreover, ABCG2 seems to have a key function in stem cell protection/regulation, and also in hypoxic defense mechanisms. Widely occurring single nucleotide polymorphisms in ABCG2 may affect absorption and distribution, altering the effectiveness and toxicity of drugs in large populations. At the clinics, overexpression of ABCG2 in tumor cells confers cancer multidrug resistance to a variety of newly developed anticancer agents. On the other hand, specific substrate mutants of ABCG2 are advocated for use as selectable markers in stem‐cell based gene therapy.
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Cites
A multidrug resistance transporter from human MCF-7 breast cancer cells
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Cited by
Bertolini, G., Roz, L., Perego, P., Tortoreto, M., Fontanella, E., Gatti, L., Pratesi, G., Fabbri, A., Andriani, F., Tinelli, S., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905653106 · Cited by 767
Role of the breast cancer resistance protein (ABCG2) in drug transport
Mao, Q. (2005) · The AAPS Journal · doi:10.1208/aapsj070112 · Cited by 405
Embryo stability and vulnerability in an always changing world
Hamdoun, A., & Epel, D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610108104 · Cited by 388
Expression and function of efflux drug transporters in the intestine
Takano, M., Yumoto, R., & Murakami, T. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.06.005 · Cited by 356
Goldstone, J. V., Hamdoun, A., Cole, B. J., Howard-Ashby, M., Nebert, D. W., Scally, M., Dean, M., Epel, D., Hahn, M. E., & Stegeman, J. J. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.08.066 · Cited by 280
Metadata
- Authors
- Sarkadi, B., Özvegy-Laczka, C., Német, K., & Váradi, A.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2004-05-08
- Volume
- 567
- Issue
- 1
- Pages
- 116-120
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1968108412
- Cited by
- 282
- References
- 46
- FWCI
- 13.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sarkadi, B., Özvegy-Laczka, C., Német, K., & Váradi, A. (2004). ABCG2 – a transporter for all seasons. FEBS Letters. https://doi.org/10.1016/j.febslet.2004.03.123
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
