The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Building and breeding molecules to spy on cells and tumors
Abstract
Imaging of biochemical processes in living cells and organisms is essential for understanding how genes and gene products work together in space and time and in health and disease. Such imaging depends crucially on indicator molecules designed to maximize sensitivity and specificity. These molecules can be entirely synthetic, entirely genetically encoded macromolecules, or hybrid combinations, each approach having its own pros and cons. Recent examples from the author's laboratory include peptides whose uptake into cells is triggered by proteases typical of tumors, monomeric red fluorescent proteins and biarsenical–tetracysteine systems for determining the age and electron‐microscopic location of proteins.
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Shaner, N. C., Campbell, R. E., Steinbach, P. A., Giepmans, B. N. G., Palmer, A. E., & Tsien, R. Y. (2004) · Nature Biotechnology · doi:10.1038/nbt1037 · Cited by 4,619
Self-citationGlobal analysis of protein localization in budding yeast
Huh, W.-K., Falvo, J. V., Gerke, L. C., Carroll, A. S., Howson, R. W., Weissman, J. S., & O'Shea, E. K. (2003) · Nature · doi:10.1038/nature02026 · Cited by 4,248
Hanson, G. T., Aggeler, R., Oglesbee, D., Cannon, M., Capaldi, R. A., Tsien, R. Y., & Remington, S. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312846200 · Cited by 988
Self-citationImaging Dynamic Redox Changes in Mammalian Cells with Green Fluorescent Protein Indicators
Dooley, C. T., Dore, T. M., Hanson, G. T., Jackson, W. C., Remington, S. J., & Tsien, R. Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312847200 · Cited by 776
Self-citationImaging tri-fusion multimodality reporter gene expression in living subjects
Ray, P., De, A., Min, J.-J., Tsien, R. Y., & Gambhir, S. S. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-1816 · Cited by 329
Self-citation
Cited by
Going deeper than microscopy: the optical imaging frontier in biology
Ntziachristos, V. (2010) · Nature Methods · doi:10.1038/nmeth.1483 · Cited by 1,896
Cox, T. R., & Erler, J. T. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.004077 · Cited by 1,569
Biosensors and their applications – A review
Mehrotra, P. (2016) · Journal of Oral Biology and Craniofacial Research · doi:10.1016/j.jobcr.2015.12.002 · Cited by 1,526
Fluorescent Proteins and Their Applications in Imaging Living Cells and Tissues
Chudakov, D. M., Matz, M. V., Lukyanov, S., & Lukyanov, K. A. (2010) · Physiological Reviews · doi:10.1152/physrev.00038.2009 · Cited by 1,375
Advances in fluorescent protein technology
Shaner, N. C., Patterson, G. H., & Davidson, M. W. (2007) · Journal of Cell Science · doi:10.1242/jcs.005801 · Cited by 787
Metadata
- Authors
- Tsien, R. Y.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2004-11-23
- Volume
- 579
- Issue
- 4
- Pages
- 927-932
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1998337135
- Cited by
- 295
- References
- 5
- FWCI
- 15.93
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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