The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation
Open accessAbstract
Histone acetyltransferases (HATs) regulate transcription, chromatin structure and DNA repair. Here, we utilized a novel HAT inhibitor, anacardic acid, to examine the role of HATs in the DNA damage response. Anacardic acid inhibits the Tip60 HAT in vitro, and blocks the Tip60‐dependent activation of the ATM and DNA–PKcs protein kinases by DNA damage in vivo. Further, anacardic acid sensitizes human tumor cells to the cytotoxic effects of ionizing radiation. These results demonstrate a central role for HATs such as Tip60 in regulating the DNA damage response. HAT inhibitors provide a novel therapeutic approach for increasing the sensitivity of tumors to radiation therapy.
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Citations
Cites
A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM
Sun, Y., Jiang, X., Chen, S., Fernandes, N., & Price, B. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504211102 · Cited by 738
Self-citationMurr, R., Loizou, J. I., Yang, Y.-G., Cuenin, C., Li, H., Wang, Z.-Q., & Herceg, Z. (2006) · Nature Cell Biology · doi:10.1038/ncb1343 · Cited by 613
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Rodríguez-Paredes, M., & Esteller, M. (2011) · Nature Medicine · doi:10.1038/nm.2305 · Cited by 1,205
Gringhuis, S. I., den Dunnen, J., Litjens, M., van het Hof, B., van Kooyk, Y., & Geijtenbeek, T. B. H. (2007) · Immunity · doi:10.1016/j.immuni.2007.03.012 · Cited by 586
Activation and regulation of ATM kinase activity in response to DNA double-strand breaks
Lee, J.-H., & Paull, T. T. (2007) · Oncogene · doi:10.1038/sj.onc.1210872 · Cited by 545
Gringhuis, S. I., den Dunnen, J., Litjens, M., van der Vlist, M., Wevers, B., Bruijns, S. C. M., & Geijtenbeek, T. B. H. (2009) · Nature Immunology · doi:10.1038/ni.1692 · Cited by 489
Epigenetic diet: impact on the epigenome and cancer
Hardy, T. M., & Tollefsbol, T. O. (2011) · Epigenomics · doi:10.2217/epi.11.71 · Cited by 401
Metadata
- Authors
- Sun, Y., Jiang, X., Chen, S., & Price, B. D.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2006-07-10
- Volume
- 580
- Issue
- 18
- Pages
- 4353-4356
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2143716699
- Cited by
- 234
- References
- 2
- FWCI
- 3.07
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sun, Y., Jiang, X., Chen, S., & Price, B. D. (2006). Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation. FEBS Letters. https://doi.org/10.1016/j.febslet.2006.06.092
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
