Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Bakkenist, C. J., & Kastan, M. B. (2003) · Nature · doi:10.1038/nature01368 · Cited by 3,466 · see citing works

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., et al. (1995) · Science · doi:10.1126/science.7792600 · Cited by 2,785 · see citing works

ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2005) · Science · doi:10.1126/science.1108297 · Cited by 1,424 · see citing works

Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage

Falck, J., Coates, J., & Jackson, S. P. (2005) · Nature · doi:10.1038/nature03442 · Cited by 1,248 · see citing works

The hMre11/hRad50 Protein Complex and Nijmegen Breakage Syndrome: Linkage of Double-Strand Break Repair to the Cellular DNA Damage Response

Carney, J. P., Maser, R. S., Olivares, H., Davis, E. M., Le Beau, M., Yates, J. R., Hays, L., Morgan, W. F., & Petrini, J. H. J. (1998) · Cell · doi:10.1016/s0092-8674(00)81175-7 · Cited by 1,226 · see citing works

Nibrin, a Novel DNA Double-Strand Break Repair Protein, Is Mutated in Nijmegen Breakage Syndrome

Varon, R., Vissinga, C., Platzer, M., Cerosaletti, K. M., Chrzanowska, K. H., Saar, K., Beckmann, G., Seemanová, E., Cooper, P. R., Nowak, N. J., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81174-5 · Cited by 1,079 · see citing works

Requirement of the MRN complex for ATM activation by DNA damage

Uziel, T., Lerenthal, Y., Moyal, L., Andegeko, Y., Mittelman, L., & Shiloh, Y. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg541 · Cited by 1,075 · see citing works

The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder

Stewart, G. S., Maser, R. S., Stankovic, T., Bressan, D. A., Kaplan, M. I., Jaspers, N. G. J., Raams, A., Byrd, P. J., Petrini, J. H. J., & Taylor, A. M. R. (1999) · Cell · doi:10.1016/s0092-8674(00)81547-0 · Cited by 1,060 · see citing works

Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

Cortez, D., Wang, Y., Qin, J., & Elledge, S. J. (1999) · Science · doi:10.1126/science.286.5442.1162 · Cited by 1,020 · see citing works

ATR and ATRIP: Partners in Checkpoint Signaling

Cortez, D., Guntuku, S., Qin, J., & Elledge, S. J. (2001) · Science · doi:10.1126/science.1065521 · Cited by 985 · see citing works

Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair

Botuyan, M. V., Lee, J., Ward, I. M., Kim, J., Thompson, J. R., Chen, J., & Mer, G. (2006) · Cell · doi:10.1016/j.cell.2006.10.043 · Cited by 973 · see citing works

P53 Binding Protein 1 (53bp1) Is an Early Participant in the Cellular Response to DNA Double-Strand Breaks

Schultz, L. B., Chehab, N. H., Malikzay, A., & Halazonetis, T. D. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.7.1381 · Cited by 897 · see citing works

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

Lim, D.-S., Kim, S.-T., Xu, B., Maser, R. S., Lin, J., Petrini, J. H. J., & Kastan, M. B. (2000) · Nature · doi:10.1038/35007091 · Cited by 786 · see citing works

Direct Activation of the ATM Protein Kinase by the Mre11/Rad50/Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2004) · Science · doi:10.1126/science.1091496 · Cited by 762 · see citing works

A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM

Sun, Y., Jiang, X., Chen, S., Fernandes, N., & Price, B. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504211102 · Cited by 738 · see citing works

Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damagePreprint

Kim, S., Xu, B., & Kastan, M. B. (2002) · Genes & Development · doi:10.1101/gad.970602 · Cited by 581 · see citing works

53BP1, a Mediator of the DNA Damage Checkpoint

Wang, B., Matsuoka, S., Carpenter, P. B., & Elledge, S. J. (2002) · Science · doi:10.1126/science.1076182 · Cited by 578 · see citing works

Involvement of Brca1 in S-Phase and G 2 -Phase Checkpoints after Ionizing Irradiation

Xu, B., Kim, S., & Kastan, M. B. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.10.3445-3450.2001 · Cited by 540 · see citing works

The ATM-mediated DNA-damage response: taking shape

Shiloh, Y. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.05.004 · Cited by 539 · see citing works

The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species

Savitsky, K., Sfez, S., Tagle, D. A., Ziv, Y., Sartiel, A., Collins, F. S., Shiloh, Y., & Rotman, G. (1995) · Human Molecular Genetics · doi:10.1093/hmg/4.11.2025 · Cited by 535 · see citing works

Phosphorylation of SMC1 is a critical downstream event in the ATM–NBS1–BRCA1 pathwayPreprint

Kitagawa, R., Bakkenist, C. J., McKinnon, P. J., & Kastan, M. B. (2004) · Genes & Development · doi:10.1101/gad.1200304 · Cited by 528 · see citing works

Adenovirus oncoproteins inactivate the Mre11–Rad50–NBS1 DNA repair complex

Stracker, T. H., Carson, C. T., & Weitzman, M. D. (2002) · Nature · doi:10.1038/nature00863 · Cited by 522 · see citing works

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpointPreprint

Yazdi, P. T., Wang, Y., Zhao, S., Patel, N., Lee, E. Y.-H. P., & Qin, J. (2002) · Genes & Development · doi:10.1101/gad.970702 · Cited by 505 · see citing works

The Mre11 complex is required for ATM activation and the G2/M checkpoint

Carson, C. T., Schwartz, R. A., Stracker, T. H., Lilley, C. E., Lee, D. V., & Weitzman, M. D. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg630 · Cited by 502 · see citing works

Tumor Suppressor P53 Binding Protein 1 (53bp1) Is Involved in DNA Damage–Signaling Pathways

Rappold, I., Iwabuchi, K., Date, T., & Chen, J. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.153.3.613 · Cited by 487 · see citing works

ATAXIA-TELANGIECTASIA AND THE NIJMEGEN BREAKAGE SYNDROME: Related Disorders But Genes Apart

Shiloh, Y. (1997) · Annual Review of Genetics · doi:10.1146/annurev.genet.31.1.635 · Cited by 482 · see citing works

Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair

Berkovich, E., Monnat, R. J., & Kastan, M. B. (2007) · Nature Cell Biology · doi:10.1038/ncb1599 · Cited by 477 · see citing works

ATM-dependent phosphorylation of nibrin in response to radiation exposure

Gatei, M., Young, D., Cerosaletti, K. M., Desai-Mehta, A., Spring, K., Kozlov, S., Lavin, M. F., Gatti, R. A., Concannon, P., & Khanna, K. (2000) · Nature Genetics · doi:10.1038/75508 · Cited by 468 · see citing works

The Rad9–Hus1–Rad1 (9–1–1) clamp activates checkpoint signaling via TopBP1Preprint

Delacroix, S., Wagner, J. M., Kobayashi, M., Yamamoto, K.-I., & Karnitz, L. M. (2007) · Genes & Development · doi:10.1101/gad.1547007 · Cited by 454 · see citing works

ATM Activation and Its Recruitment to Damaged DNA Require Binding to the C Terminus of Nbs1

You, Z., Chahwan, C., Bailis, J. M., Hunter, T. R., & Russell, P. R. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.13.5363-5379.2005 · Cited by 428 · see citing works

p53‐inducible Wip1 phosphatase mediates a negative feedback regulation of p38 MAPK‐p53 signaling in response to UV radiation

Takekawa, M., Adachi, M., Nakahata, A., Nakayama, I., Itoh, F., Tsukuda, H., Taya, Y., & Imai, K. (2000) · The EMBO Journal · doi:10.1093/emboj/19.23.6517 · Cited by 419 · see citing works

Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation

Luo, G., Yao, M. S., Bender, C. F., Mills, M., Bladl, A. R., Bradley, A., & Petrini, J. H. J. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.13.7376 · Cited by 408 · see citing works

53BP1 functions in an ATM-dependent checkpoint pathway that is constitutively activated in human cancer

DiTullio, R. A., Mochan, T. A., Venere, M., Bártková, J., Sehested, M., Bártek, J., & Halazonetis, T. D. (2002) · Nature Cell Biology · doi:10.1038/ncb892 · Cited by 399 · see citing works

Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice

Zhu, J., Petersen, S., Tessarollo, L., & Nussenzweig, A. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00019-7 · Cited by 374 · see citing works

Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage

Anderson, L., Henderson, C., & Adachi, Y. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.5.1719-1729.2001 · Cited by 367 · see citing works

Genetic Analysis of BRCA1 Function in a Defined Tumor Cell Line

Scully, R., Ganesan, S., Vlasakova, K., Chen, J., Socolovsky, M., & Livingston, D. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80238-5 · Cited by 359 · see citing works

Wip1 Phosphatase Modulates ATM-Dependent Signaling Pathways

Shreeram, S., Demidov, O. N., Hee, W. K., Yamaguchi, H., Onishi, N., Kek, C., Timofeev, O. N., Dudgeon, C., Fornace, A. J., Anderson, C. W., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.07.010 · Cited by 350 · see citing works

Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells

Xiao, Y. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.15.2985 · Cited by 316 · see citing works

FAT: a novel domain in PIK-related kinases

Bosotti, R., Isacchi, A., & Sonnhammer, E. L. L. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01563-2 · Cited by 313 · see citing works

NBS1 Localizes to γ-H2AX Foci through Interaction with the FHA/BRCT Domain

Kobayashi, J., Tauchi, H., Sakamoto, S., Nakamura, A., Morishima, K.-I., Matsuura, S., Kobayashi, T., Tamai, K., Tanimoto, K., & Komatsu, K. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01259-9 · Cited by 306 · see citing works

ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanismPreprint

Nakada, D., Matsumoto, K., & Sugimoto, K. (2003) · Genes & Development · doi:10.1101/gad.1099003 · Cited by 284 · see citing works

Involvement of novel autophosphorylation sites in ATM activation

Kozlov, S., Graham, M. E., Peng, C., Chen, P., Robinson, P. J., & Lavin, M. F. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601231 · Cited by 283 · see citing works

The Rad9-Hus1-Rad1 Checkpoint Clamp Regulates Interaction of TopBP1 with ATR

Lee, J., Kumagai, A., & Dunphy, W. G. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704635200 · Cited by 281 · see citing works

Interaction of FANCD2 and NBS1 in the DNA damage response

Nakanishi, K., Taniguchi, T., Ranganathan, V., New, H. V., Moreau, L. A., Stotsky, M., Mathew, C. G., Kastan, M. B., Weaver, D. T., & D’Andrea, A. D. (2002) · Nature Cell Biology · doi:10.1038/ncb879 · Cited by 270 · see citing works

Autophosphorylation of ataxia‐telangiectasia mutated is regulated by protein phosphatase 2A

Goodarzi, A. A., Jonnalagadda, J. C., Douglas, P., Young, D., Ye, R., Moorhead, G. B. G., Lees‐Miller, S. P., & Khanna, K. K. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600455 · Cited by 269 · see citing works

A subset of ATM‐ and ATR‐dependent phosphorylation events requires the BRCA1 protein

Foray, N., Marot, D., Gabriel, A., Randrianarison-Huetz, V., Carr, A. M., Perricaudet, M., Ashworth, A., & Jeggo, P. A. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg274 · Cited by 250 · see citing works

Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation

Sun, Y., Jiang, X., Chen, S., & Price, B. D. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.06.092 · Cited by 236 · see citing works

Two-step activation of ATM by DNA and the Mre11–Rad50–Nbs1 complex

Dupré, A., Boyer-Châtenet, L., & Gautier, J. (2006) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1090 · Cited by 233 · see citing works

The Mre11 complex and ATM: collaborating to navigate S phase

Petrini, J. H. J. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00091-0 · Cited by 228 · see citing works

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

Difilippantonio, S., Celeste, A., Fernandez-Capetillo, O., Chen, H.-T., Martin, B. R. S., Laethem, F. V., Yang, Y.-P., Petukhova, G. V., Eckhaus, M., Feigenbaum, L., et al. (2005) · Nature Cell Biology · doi:10.1038/ncb1270 · Cited by 227 · see citing works

Involvement of Human MOF in ATM Function

Gupta, A. K. D., Sharma, G. G., Young, C. S. H., Agarwal, M., Smith, E. R., Paull, T. T., Lucchesi, J. C., Khanna, K. K., Ludwig, T., & Pandita, T. K. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.12.5292-5305.2005 · Cited by 220 · see citing works

An alternative mode of translation permits production of a variant NBS1 protein from the common Nijmegen breakage syndrome allele

Maser, R. S., Zinkel, R. A., & Petrini, J. H. J. (2001) · Nature Genetics · doi:10.1038/86920 · Cited by 217 · see citing works

Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo

Pellegrini, M., Celeste, A., Difilippantonio, S., Guo, R., Wang, W., Feigenbaum, L., & Nussenzweig, A. (2006) · Nature · doi:10.1038/nature05112 · Cited by 207 · see citing works

Chk2 Activation Dependence on Nbs1 after DNA Damage

Buscemi, G., Savio, C., Zannini, L., Miccichè, F., Masnada, D., Nakanishi, M., Tauchi, H., Komatsu, K., Mizutani, S., Khanna, K., et al. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.15.5214-5222.2001 · Cited by 201 · see citing works

Distinct Functional Domains of Nibrin Mediate Mre11 Binding, Focus Formation, and Nuclear Localization

Desai-Mehta, A., Cerosaletti, K. M., & Concannon, P. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.6.2184-2191.2001 · Cited by 196 · see citing works

53BP1 and NFBD1/MDC1-Nbs1 function in parallel interacting pathways activating ataxia-telangiectasia mutated (ATM) in response to DNA damage.

Mochan, T. A., Venere, M., DiTullio, R. A., & Halazonetis, T. D. (2003) · PubMed · Cited by 192 · see citing works

Ataxia Telangiectasia Mutated (ATM) Kinase and ATM and Rad3 Related Kinase Mediate Phosphorylation of Brca1 at Distinct and Overlapping Sites

Gatei, M. H., Zhou, B. S., Hobson, K., Scott, S. P., Young, D., & Khanna, K. K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011681200 · Cited by 189 · see citing works

Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation.

Xu, B., O’Donnell‐Luria, A., Kim, S., & Kastan, M. B. (2002) · PubMed · Cited by 189 · see citing works

Requirement of protein phosphatase 5 in DNA-damage-induced ATM activationPreprint

Ali, A., Zhang, J., Bao, S., Liu, I., Otterness, D. M., Dean, N. M., Abraham, R. T., & Wang, X.-F. (2004) · Genes & Development · doi:10.1101/gad.1176004 · Cited by 170 · see citing works

BRCA1-BARD1 Complexes Are Required for p53Ser-15 Phosphorylation and a G1/S Arrest following Ionizing Radiation-induced DNA Damage

Fabbro, M., Savage, K. I., Hobson, K., Deans, A. J., Powell, S. N., McArthur, G. A., & Khanna, K. K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405372200 · Cited by 160 · see citing works

The Forkhead-associated Domain of NBS1 Is Essential for Nuclear Foci Formation after Irradiation but Not Essential for hRAD50·hMRE11·NBS1 Complex DNA Repair Activity

Tauchi, H., Kobayashi, J., Morishima, K.-I., Matsuura, S., Nakamura, A., Shiraishi, T., Ito, E., Masnada, D., Delia, D., & Komatsu, K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c000578200 · Cited by 156 · see citing works

Activation of Ataxia Telangiectasia-mutated DNA Damage Checkpoint Signal Transduction Elicited by Herpes Simplex Virus Infection

Shirata, N., Kudoh, A., Daikoku, T., Tatsumi, Y., Fujita, M., Kiyono, T., Sugaya, Y., Isomura, H., Ishizaki, K., & Tsurumi, T. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m500976200 · Cited by 138 · see citing works

The Haploinsufficient Tumor Suppressor p18 Upregulates p53 via Interactions with ATM/ATR

Park, B.-J., Kang, J. W., Lee, S., Choi, S., Shin, Y. K., Ahn, Y. H., Choi, Y. H., Choi, D., Lee, K. S., & Kim, S. (2005) · Cell · doi:10.1016/j.cell.2004.11.054 · Cited by 135 · see citing works

Adenovirus Type 5 E4orf3 Protein Targets the Mre11 Complex to Cytoplasmic Aggresomes

Araujo, F. D., Stracker, T. H., Carson, C. T., Lee, D. V., & Weitzman, M. D. (2005) · Journal of Virology · doi:10.1128/jvi.79.17.11382-11391.2005 · Cited by 127 · see citing works

The carboxy terminus of NBS1 is required for induction of apoptosis by the MRE11 complex

Stracker, T. H., Morales, M., Couto, S. S., Hussein, H., & Petrini, J. H. J. (2007) · Nature · doi:10.1038/nature05740 · Cited by 127 · see citing works

Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest

Girard, P.-M., Riballo, E., Begg, A. C., Waugh, A., & Jeggo, P. A. (2002) · Oncogene · doi:10.1038/sj.onc.1205596 · Cited by 123 · see citing works

Rad50 Adenylate Kinase Activity Regulates DNA Tethering by Mre11/Rad50 Complexes

Bhaskara, V., Dupré, A., Lengsfeld, B. M., Hopkins, B. B., Chan, A., Lee, J., Zhang, X., Gautier, J., Zakian, V. A., & Paull, T. T. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.028 · Cited by 119 · see citing works

Residual Ataxia Telangiectasia Mutated Protein Function in Cells from Ataxia Telangiectasia Patients, with 5762ins137 and 7271T→G Mutations, Showing a Less Severe Phenotype

Stewart, G. S., Last, J. I. K., Stanković, T., Kingsbury, N., Kidd, A., Byrd, P. J., & Taylor, A. M. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103160200 · Cited by 106 · see citing works

Mre11 Assembles Linear DNA Fragments into DNA Damage Signaling Complexes

Costanzo, V., Paull, T., Gottesman, M., & Gautier, J. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020110 · Cited by 106 · see citing works

The Rad50 Signature Motif: Essential to ATP Binding and Biological Function

Moncalián, G., Lengsfeld, B. M., Bhaskara, V., Hopfner, K., Kärcher, A., Alden, E., Tainer, J. A., & Paull, T. T. (2003) · Journal of Molecular Biology · doi:10.1016/j.jmb.2003.11.026 · Cited by 101 · see citing works

Regulation of Mre11/Rad50 by Nbs1

Lee, J., Ghirlando, R., Bhaskara, V., Hoffmeyer, M. R., Gu, J. H., & Paull, T. T. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m308705200 · Cited by 99 · see citing works

Negative Cell Cycle Regulation and DNA Damage-inducible Phosphorylation of the BRCT Protein 53BP1

Xia, Z., Morales, J. C., Dunphy, W. G., & Carpenter, P. B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m007665200 · Cited by 96 · see citing works

ATP Activates Ataxia-Telangiectasia Mutated (ATM) in Vitro

Kozlov, S., Gueven, N., Keating, K. E., Ramsay, J., & Lavin, M. F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300003200 · Cited by 91 · see citing works

SV40 T antigen interacts with Nbs1 to disrupt DNA replication controlPreprint

Wu, X., Avni, D., Chiba, T., Yan, F., Zhao, Q., Lin, Y., Heng, H., & Livingston, D. (2004) · Genes & Development · doi:10.1101/gad.1182804 · Cited by 88 · see citing works

Active Role for Nibrin in the Kinetics of Atm Activation

Cerosaletti, K. M., Wright, J. A., & CONCANNON, P. J. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.5.1691-1699.2006 · Cited by 85 · see citing works

ATMIN defines an NBS1‐independent pathway of ATM signalling

Kanu, N., & Behrens, A. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601733 · Cited by 84 · see citing works

NFBD1, a Novel Nuclear Protein with Signature Motifs of FHA and BRCT, and an Internal 41-Amino Acid Repeat Sequence, Is an Early Participant in DNA Damage Response

Shang, Y. L., Bodero, A. J., & Chen, P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210749200 · Cited by 82 · see citing works

The p18 component of the multisynthetase complex shares a protein motif with the β and γ subunits of eukaryotic elongation factor 1

Quevillon‐Chéruel, S., & Mirande, M. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)01005-8 · Cited by 82 · see citing works

Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis

Difilippantonio, S., Celeste, A., Kruhlak, M. J., Lee, Y., Difilippantonio, M. J., Feigenbaum, L., Jackson, S. P., McKinnon, P. J., & Nussenzweig, A. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070319 · Cited by 81 · see citing works

Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway

McConnell, J. L., Gomez, R. J., McCorvey, L. R. A., Law, B. K., & Wadzinski, B. E. (2007) · Oncogene · doi:10.1038/sj.onc.1210406 · Cited by 80 · see citing works

Nibrin Forkhead-associated Domain and Breast Cancer C-terminal Domain Are Both Required for Nuclear Focus Formation and Phosphorylation

Cerosaletti, K. M., & Concannon, P. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211689200 · Cited by 74 · see citing works

Functional analysis of FHA and BRCT domains of NBS1 in chromatin association and DNA damage responses

Zhao, S. (2002) · Nucleic Acids Research · doi:10.1093/nar/gkf612 · Cited by 70 · see citing works

Interaction between Protein Phosphatase 5 and the A subunit of Protein Phosphatase 2A

Lubert, E. J., Hong, Y., & Sarge, K. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106906200 · Cited by 64 · see citing works

Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage.

Lee, J. H., Xu, B., Lee, C. H., Ahn, J.-Y., Song, M. S., Lee, H., Canman, C. E., Lee, J., Kastan, M. B., & Lim, D. (2003) · PubMed · Cited by 64 · see citing works

DNA repair: The Nijmegen breakage syndrome protein

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Detection of a tandem BRCT in Nbs1 and Xrs2 with functional implications in the DNA damage response

Becker, E., Meyer, V., Madaoui, H., & Guérois, R. (2006) · Bioinformatics · doi:10.1093/bioinformatics/btl075 · Cited by 60 · see citing works

Identification of Domains of Ataxia-telangiectasia Mutated Required for Nuclear Localization and Chromatin Association

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ATM-dependent Dissociation of B55 Regulatory Subunit from Nuclear PP2A in Response to Ionizing Radiation

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The RNA-binding Protein Fused in Sarcoma (FUS) Functions Downstream of Poly(ADP-ribose) Polymerase (PARP) in Response to DNA Damage

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The Interaction of CtIP and Nbs1 Connects CDK and ATM to Regulate HR–Mediated Double-Strand Break Repair

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SIRT1 collaborates with ATM and HDAC1 to maintain genomic stability in neurons

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Genetic causes of microcephaly and lessons for neuronal development

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A nuclear poly(ADP-Ribose)-dependent signalosome confers DNA damage-induced IκB kinase activation.

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CtIP Links DNA Double-Strand Break Sensing to Resection

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Cell-Cell Communication in the Tumor Microenvironment, Carcinogenesis, and Anticancer Treatment

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Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA‐PK

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Overexpression of the Circadian Clock Gene Bmal1 Increases Sensitivity to Oxaliplatin in Colorectal Cancer

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Evolution of human vocal production

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Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo

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DNA lesions sequestered in micronuclei induce a local defective-damage response

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Double-strand break repair by homologous recombination in primary mouse somatic cells requires BRCA1 but not the ATM kinase

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Inhibition of AMP-activated Protein Kinase α (AMPKα) by Doxorubicin Accentuates Genotoxic Stress and Cell Death in Mouse Embryonic Fibroblasts and Cardiomyocytes

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Double-strand breaks in ribosomal RNA genes activate a distinct signaling and chromatin response to facilitate nucleolar restructuring and repair

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FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage

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DIM (3,3′-diindolylmethane) confers protection against ionizing radiation by a unique mechanism

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ATM prevents DSB formation by coordinating SSB repair and cell cycle progression

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Ack1-mediated Androgen Receptor Phosphorylation Modulates Radiation Resistance in Castration-resistant Prostate Cancer

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Role of p53 in human chondrocyte apoptosis in response to shear strain

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Regulation of DNA replication by the S-phase DNA damage checkpoint

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FTO-targeted siRNA delivery by MSC-derived exosomes synergistically alleviates dopaminergic neuronal death in Parkinson's disease via m6A-dependent regulation of ATM mRNA

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Homeostatic nuclear RAGE–ATM interaction is essential for efficient DNA repair

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Molecular aberrations, targeted therapy, and renal cell carcinoma: current state-of-the-art

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Caffeic acid phenethyl ester induced cell cycle arrest and growth inhibition in androgen-independent prostate cancer cells via regulation of Skp2, p53, p21Cip1 and p27Kip1

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ATM pathway activation limits R-loop-associated genomic instability in Werner syndrome cells

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Mitochondria at the crossroads of ATM-mediated stress signaling and regulation of reactive oxygen species

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CD155/TIGIT, a novel immune checkpoint in human cancers (Review)

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Targeting BRCA1‐BER deficient breast cancer by ATM or DNA‐PKcs blockade either alone or in combination with cisplatin for personalized therapy

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Regulators of homologous recombination repair as novel targets for cancer treatment

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Dancing on Damaged Chromatin: Functions of ATM and the RAD50/MRE11/NBS1 Complex in Cellular Responses to DNA Damage

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Epigenetic regulation of genomic integrity

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ATM activation by DNA double-strand breaks through

Lee, J., & Paull, T. T. (2016)

ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

Lee, J.-H., & Paull, T. T. (2005) · Science · doi:10.1126/science.1108297 · Cited by 1,424 · see citing works

Characterization of the mechanisms of ATM activation by the MRN complex and DNA

Lee, J. H. (2005) · Texas ScholarWorks (Texas Digital Library)

Two-step activation of ATM by DNA and the Mre11–Rad50–Nbs1 complex

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Direct Activation of the ATM Protein Kinase by the Mre11/Rad50/Nbs1 Complex

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