The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Epidermal sphingolipids: Metabolism, function, and roles in skin disorders
Abstract
Mammalian epidermis produces and delivers large quantities of glucosylceramide and sphingomyelin precursors to stratum corneum extracellular domains, where they are hydrolyzed to corresponding ceramide species. This cycle of lipid precursor formation and subsequent hydrolysis represents a mechanism that protects the epidermis against potentially harmful effects of ceramide accumulation within nucleated cell layers. Prominent skin disorders, such as psoriasis and atopic dermatitis, have diminished epidermal ceramide levels, reflecting altered sphingolipid metabolism, that may contribute to disease severity/progression. Enzymatic processes in the hydrolysis of glucosylceramide and sphingomyelin, and the roles of sphingolipids in skin diseases, are the focus of this review.
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Cites
Impaired sphingomyelinase activity and epidermal differentiation in atopic dermatitis
Jensen, J.-M., Fölster-Holst, R., Baranowsky, A., Schunck, M., Winoto-Morbach, S., Neumann, C., Schütze, S., & Proksch, E. (2004) · Journal of Investigative Dermatology · doi:10.1111/j.0022-202x.2004.22621.x · Cited by 309
6-Hydroxy-4-sphingenine in human epidermal ceramides.
Robson, K. J., Stewart, M. E., Michelsen, S., Lazo, N. D., & Downing, D. T. (1994) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)39952-1 · Cited by 263
Cited by
Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of Sphingolipidomics
Merrill, A. H. (2011) · Chemical Reviews · doi:10.1021/cr2002917 · Cited by 785
Eckhart, L., Lippens, S., Tschachler, E., & Declercq, W. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.06.010 · Cited by 515
Glycosphingolipids—Nature, Function, and Pharmacological Modulation
Wennekes, T., van den Berg, R. J. B. H. N., Boot, R. G., van der Marel, G. A., Overkleeft, H. S., & Aerts, J. M. F. G. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200902620 · Cited by 288
Ceramide biosynthesis in keratinocyte and its role in skin function
Mizutani, Y., Mitsutake, S., Tsuji, K., Kihara, A., & Igarashi, Y. (2009) · Biochimie · doi:10.1016/j.biochi.2009.04.001 · Cited by 255
Bioactive lipid mediators in skin inflammation and immunity
Kendall, A. C., & Nicolaou, A. (2013) · Progress in Lipid Research · doi:10.1016/j.plipres.2012.10.003 · Cited by 229
Metadata
- Authors
- Holleran, W. M., Takagi, Y., & Uchida, Y.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2006-09
- Volume
- 580
- Issue
- 23
- Pages
- 5456-5466
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1976620131
- Cited by
- 266
- References
- 2
- FWCI
- 4.79
- Type
- journal article
- Language
- en
- Open access
- closed
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- Holleran, W. M., Takagi, Y., & Uchida, Y. (2006). Epidermal sphingolipids: Metabolism, function, and roles in skin disorders. FEBS Letters. https://doi.org/10.1016/j.febslet.2006.08.039
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