The DOI matches its Crossref record; 211 of the 211 references it cites were found in a registry or an index.
Glycosphingolipids—Nature, Function, and Pharmacological Modulation
Abstract
The discovery of the glycosphingolipids is generally attributed to Johan L. W. Thudichum, who in 1884 published on the chemical composition of the brain. In his studies he isolated several compounds from ethanolic brain extracts which he coined cerebrosides. He subjected one of these, phrenosin (now known as galactosylceramide), to acid hydrolysis, and this produced three distinct components. One he identified as a fatty acid and another proved to be an isomer of D‐glucose, which is now known as D‐galactose. The third component, with an “alkaloidal nature”, presented “many enigmas” to Thudichum, and therefore he named it sphingosine, after the mythological riddle of the Sphinx. Today, sphingolipids and their glycosidated derivatives are the subjects of intense study aimed at elucidating their role in the structural integrity of the cell membrane, their participation in recognition and signaling events, and in particular their involvement in pathological processes that are at the basis of human disease (for example, sphingolipidoses and diabetes type 2). This Review details some of the recent findings on the biosynthesis, function, and degradation of glycosphingolipids in man, with a focus on the glycosphingolipid glucosylceramide. Special attention is paid to the clinical relevance of compounds directed at interfering with the factors responsible for glycosphingolipid metabolism.
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Cites
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Cited by
Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of Sphingolipidomics
Merrill, A. H. (2011) · Chemical Reviews · doi:10.1021/cr2002917 · Cited by 785
Metabolic features of chronic fatigue syndrome
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Van der Lienden, M. J. C., Gaspar, P., Boot, R., Aerts, J. M. F. G., & Van Eijk, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010066 · Cited by 84
Self-citation
Metadata
- Authors
- Wennekes, T., van den Berg, R. J. B. H. N., Boot, R. G., van der Marel, G. A., Overkleeft, H. S., & Aerts, J. M. F. G.
- Venue
- Angewandte Chemie International Edition
- Publisher
- Wiley
- Published
- 2009-11-04
- Volume
- 48
- Issue
- 47
- Pages
- 8848-8869
- ISSN
- 1433-7851 (ISSN-L)
- 1521-3773
- OpenAlex
- W2149949019
- Cited by
- 288
- References
- 211
- FWCI
- 9.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wennekes, T., van den Berg, R. J. B. H. N., Boot, R. G., van der Marel, G. A., Overkleeft, H. S., & Aerts, J. M. F. G. (2009). Glycosphingolipids—Nature, Function, and Pharmacological Modulation. Angewandte Chemie International Edition. https://doi.org/10.1002/anie.200902620
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