The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Collagen matrix deposition is dramatically enhanced in vitro when crowded with charged macromolecules: The biological relevance of the excluded volume effect
Abstract
The excluded volume effect (EVE) rules all life processes. It is created by macromolecules that occupy a given volume thereby confining other molecules to the remaining space with large consequences on reaction kinetics and molecular assembly. Implementing EVE in fibroblast culture accelerated conversion of procollagen to collagen by procollagen C‐proteinase (PCP/BMP‐1) and proteolytic modification of its allosteric regulator, PCOLCE1. This led to a 20–30‐ and 3–6‐fold increased collagen deposition in two‐ and three‐dimensional cultures, respectively, and creation of crosslinked collagen footprints beneath cells. Important parameters correlating with accelerated deposition were hydrodynamic radius of macromolecules and their negative charge density.
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Citations
Cites
Macromolecular crowding: obvious but underappreciated
Ellis, R. J. (2001) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(01)01938-7 · Cited by 2,309
Minton, A. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r100005200 · Cited by 1,474 · cited 1×
“of the same reactions operating under crowded conditions within cells or the extracellular compartment [1,30].”
BackgroundMacromolecular crowding: an important but neglected aspect of the intracellular environment
Ellis, R. J. (2001) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(00)00172-x · Cited by 1,153 · cited 1×
“This situation is far from physiological given the fact that the total concentration of protein and RNA inside proand eukaryotic cells is in the range of 300–400 g/l [1–3] and”
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Cited by
Organ printing: Tissue spheroids as building blocks
Mironov, V., Visconti, R. P., Kasyanov, V., Forgacs, G., Drake, C. J., & Markwald, R. R. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2008.12.084 · Cited by 1,238
Wiig, H., & Swartz, M. A. (2012) · Physiological Reviews · doi:10.1152/physrev.00037.2011 · Cited by 722
Interpretation of cancer mutations using a multiscale map of protein systems
Zheng, F., Kelly, M. R., Ramms, D. J., Heintschel, M. L., Tao, K., Tutuncuoglu, B., Lee, J. J., Ono, K., Foussard, H., Chen, M., et al. (2021) · Science · doi:10.1126/science.abf3067 · Cited by 81
Metadata
- Authors
- Lareu, R. R., Subramhanya, K. H., Peng, Y., Benny, P., Chen, C., Wang, Z., Rajagopalan, R., & Raghunath, M.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2007-05-21
- Volume
- 581
- Issue
- 14
- Pages
- 2709-2714
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2148124825
- Cited by
- 164
- References
- 3
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Lareu, R. R., Subramhanya, K. H., Peng, Y., Benny, P., Chen, C., Wang, Z., Rajagopalan, R., & Raghunath, M. (2007). Collagen matrix deposition is dramatically enhanced in vitro when crowded with charged macromolecules: The biological relevance of the excluded volume effect. FEBS Letters. https://doi.org/10.1016/j.febslet.2007.05.020
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