Acute administration of 3,5‐diiodo‐l‐thyronine to hypothyroid rats affects bioenergetic parameters in rat skeletal muscle mitochondria
Abstract
We investigated the mechanism by which 3,5‐diiodo‐l‐thyronine (T2) affects skeletal muscle mitochondrial bioenergetic parameters following its acute administration to hypothyroid rats. One hour after injection, T2 increased both coupled and uncoupled respiration rates by +27% and +42%, respectively. Top‐down elasticity analysis revealed that these effects were the result of increases in the substrate oxidation and mitochondrial uncoupling. Discriminating between proton‐leak and redox‐slip processes, we identified an increased mitochondrial proton conductance as the “pathway” underlying the effect of T2 on mitochondrial uncoupling. As a whole, these results may provide a mechanism by which T2 rapidly affects energy metabolism in hypothyroid rats.
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3,5-T2 exerts important metabolic effects.
“In accordance with previous data showing that 3,5-T2 exerts important metabolic effects (Lanni et al. 1996, Lombardi et al. 2007, 2009), we have found a significant increase in the oxygen consumption of rats treated with 50 μg of 3,5-T2/100 g BW when compared with control animals.”
From Administration of 3,5-diiodothyronine (3,5-T2) causes central hypothyroidism and stimulates thyroid-sensitive tissues (2014) · cites this paper as Lombardi et al. 2007
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Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3
Brand, M. D., & Esteves, T. C. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.06.002 · Cited by 785 · see citing works
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Padron, A. S., Neto, R. A. L., Pantaleão, T. U., de Souza dos Santos, M. C., Araujo, R. L., de Andrade, B. M., da Silva Leandro, M., de Castro, J. P. S. W., Ferreira, A. C. F., & de Carvalho, D. P. (2014) · Journal of Endocrinology · doi:10.1530/joe-13-0502 · Cited by 69 · see citing works
- Authors
- Lombardi, A., Lanni, A., de Lange, P., Silvestri, E., Grasso, P., Senese, R., Goglia, F., & Moreno, M.
- Affiliations
- University of Naples Federico II (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- University of Sannio (IT)
- Corresponding author
- Goglia, Fernando
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2007-12-03
- Volume
- 581
- Issue
- 30
- Pages
- 5911-5916
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2064091200
- Cited by
- 28
- References
- 1
- Citations by year
- 2026: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 2 · 2015: 4 · 2014: 1 · 2013: 1 · 2012: 2
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- 3,5-diiodo-L-thyronine, T2*, hypothyroidism, skeletal muscle mitochondria, mitochondrial uncoupling, mitochondrial respiration, proton leak, substrate oxidation, mitochondrial bioenergetics, energy metabolism, thyroid hormones
- MeSH terms
- Animals, Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone, Diiodothyronines, Energy Metabolism, Hypothyroidism, Kinetics, Male, Malonates, Mitochondria, Muscle, Oligomycins, Oxidation-Reduction, Phosphorylation, Protons, Rats, Wistar, Muscle, Skeletal, Cell Respiration, Rats, Membrane Potential, Mitochondrial
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