Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3

Free radicals in biology and medicine

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Superoxide activates mitochondrial uncoupling proteins

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Mitochondria and neuronal survival

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Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production

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Uncoupling protein‐3: a new member of the mitochondrial carrier family with tissue‐specific expression

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Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins

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Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β-cell dysfunction, and type 2 diabetes.

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Uncoupling: new approaches to an old problem of bioenergetics

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The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP

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Uncoupling to survive? The role of mitochondrial inefficiency in ageing

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A role for uncoupling protein‐2 as a regulator of mitochondrial hydrogen peroxide generation

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Uncoupling Protein-3 Is a Mediator of Thermogenesis Regulated by Thyroid Hormone, β3-Adrenergic Agonists, and Leptin

Gong, D., He, Y., Karas, M., & Reitman, M. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.39.24129 · Cited by 740 · see citing works

UCP3: An Uncoupling Protein Homologue Expressed Preferentially and Abundantly in Skeletal Muscle and Brown Adipose Tissue

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Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants

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Energy metabolism in uncoupling protein 3 gene knockout mice

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Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean

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A signalling role for 4‐hydroxy‐2‐nonenal in regulation of mitochondrial uncoupling

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Cloning and Characterization of an Uncoupling Protein Homolog: A Potential Molecular Mediator of Human Thermogenesis

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Prevention of mitochondrial oxidative damage as a therapeutic strategy in diabetes

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Uncoupling Protein 2, in Vivo Distribution, Induction upon Oxidative Stress, and Evidence for Translational Regulation

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Superoxide production by NADH:ubiquinone oxidoreductase (complex I) depends on the pH gradient across the mitochondrial inner membrane

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Reactive oxygen species, mitochondria, apoptosis and aging

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Uncoupling proteins 2 and 3: potential regulators of mitochondrial energy metabolism.

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Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction

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Superoxide-mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction

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Reactive oxygen species, mitochondria, apoptosis and aging

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Superoxide Activates Mitochondrial Uncoupling Protein 2 from the Matrix Side

Echtay, K. S., Murphy, M. P., Smith, R. A. J., Talbot, D. A., & Brand, M. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208262200 · Cited by 388 · see citing works

Mitochondrial uncoupling proteins: from mitochondria to the regulation of energy balance

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Lack of Obesity and Normal Response to Fasting and Thyroid Hormone in Mice Lacking Uncoupling Protein-3

Gong, D., Monemdjou, S., Gavrilova, O., Leon, L. R., Marcus‐Samuels, B., Chou, C. J., Everett, C. A., Kozak, L. P., Li, C., Deng, C., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910177199 · Cited by 385 · see citing works

Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation

Zhou, Y.-T., Shimabukuro, M., Koyama, K., Lee, Y., Wang, M.-Y., Trieu, F., Newgard, C. B., & Unger, R. H. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6386 · Cited by 373 · see citing works

Structure and function of the uncoupling protein from brown adipose tissue

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Increased Uncoupling Protein-2 Levels in β-cells Are Associated With Impaired Glucose-Stimulated Insulin Secretion

Chan, C. B., De Leo, D., Joseph, J. W., McQuaid, T. S., Ha, X. F., Xu, F., Tsushima, R. G., Pennefather, P. S., Salapatek, A. M. F., & Wheeler, M. B. (2001) · Diabetes · doi:10.2337/diabetes.50.6.1302 · Cited by 341 · see citing works

Physiological Role of UCP3 May Be Export of Fatty Acids from Mitochondria When Fatty Acid Oxidation Predominates: An Hypothesis

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Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic β-cells

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Transport function and regulation of mitochondrial uncoupling proteins 2 and 3

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Uncoupling proteins 2 and 3 are highly active H ⁺ transporters and highly nucleotide sensitive when activated by coenzyme Q (ubiquinone)

Echtay, K. S., Winkler, E., Frischmuth, K., & Klingenberg, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1416 · Cited by 313 · see citing works

Role of UCP homologues in skeletal muscles and brown adipose tissue: mediators of thermogenesis or regulators of lipids as fuel substrate?

Samec, S., Seydoux, J., & Dulloo, A. G. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.9.715 · Cited by 305 · see citing works

Superoxide Activates Uncoupling Proteins by Generating Carbon-centered Radicals and Initiating Lipid Peroxidation

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Superoxide and hydrogen peroxide production by Drosophila mitochondria

Miwa, S., St‐Pierre, J., Partridge, L., & Brand, M. D. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00464-7 · Cited by 298 · see citing works

Uncoupling Protein-3 Expression in Rodent Skeletal Muscle Is Modulated by Food Intake but Not by Changes in Environmental Temperature

Boss, O., Samec, S., Kühne, F., Bijlenga, P., Assimacopoulos‐Jeannet, F., Seydoux, J., Giacobino, J., & Muzzin, P. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.1.5 · Cited by 276 · see citing works

Mitochondrial uncoupling as a target for drug development for the treatment of obesity.

Harper, J. A., Dickinson, K., & Brand, M. D. (2001) · Obesity Reviews · doi:10.1046/j.1467-789x.2001.00043.x · Cited by 250 · see citing works

Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets.

Chan, C. B., MacDonald, P. E., Saleh, M. C., Johns, D. C., Marbàn, E., & Wheeler, M. B. (1999) · Diabetes · doi:10.2337/diabetes.48.7.1482 · Cited by 242 · see citing works

Protective Role of Uncoupling Protein 2 in Atherosclerosis

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Sodium Palmitate Induces Partial Mitochondrial Uncoupling and Reactive Oxygen Species in Rat Pancreatic Isletsin Vitro1

Carlsson, C., Borg, L., & Welsh, N. (1999) · Endocrinology · doi:10.1210/endo.140.8.6908 · Cited by 238 · see citing works

The Physiological Significance of Mitochondrial Proton Leak in Animal Cells and Tissues

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A plant cold-induced uncoupling protein

Laloi, M., Klein, M., Riesmeier, J., Müller‐Röber, B., Fleury, C., Bouillaud, F., & Ricquier, D. (1997) · Nature · doi:10.1038/38156 · Cited by 230 · see citing works

A function for novel uncoupling proteins: antioxidant defense of mitochondrial matrix by translocating fatty acid peroxides from the inner to the outer membrane leaflet

Goglia, F., & Skulachev, V. P. (2003) · The FASEB Journal · doi:10.1096/fj.03-0159hyp · Cited by 229 · see citing works

UCP2 and UCP3 rise in starved rat skeletal muscle but mitochondrial proton conductance is unchanged

Cadenas, S., Buckingham, J. A., Samec, S., Seydoux, J., Din, N., Dulloo, A. G., & Brand, M. D. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)01540-9 · Cited by 227 · see citing works

The ‘Novel’‘Uncoupling’ Proteins UCP2 and UCP3: What Do They Really do? Pros and Cons for Suggested Functions

Nedergaard, J., & Cannon, B. (2003) · Experimental Physiology · doi:10.1113/eph8802502 · Cited by 226 · see citing works

Uncoupling Protein 2: A Possible Link Between Fatty Acid Excess and Impaired Glucose-Induced Insulin Secretion?

Davis‐Lameloise, N., Muzzin, P., Prentki, M., & Assimacopoulos‐Jeannet, F. (2001) · Diabetes · doi:10.2337/diabetes.50.4.803 · Cited by 226 · see citing works

An uncoupling protein homologue putatively involved in facultative muscle thermogenesis in birds

Raimbault, S., Dridi, S., Denjean, F., Lachuer, J., Couplan, E., Bouillaud, F., Bordas, A., Duchamp, C., Taouis, M., & Ricquier, D. (2001) · Biochemical Journal · doi:10.1042/0264-6021:3530441 · Cited by 221 · see citing works

Uncoupling Protein 2 Knockout Mice Have Enhanced Insulin Secretory Capacity After a High-Fat Diet

Joseph, J. W., Koshkin, V., Zhang, C.-Y., Wang, J., Lowell, B. B., Chan, C. B., & Wheeler, M. B. (2002) · Diabetes · doi:10.2337/diabetes.51.11.3211 · Cited by 220 · see citing works

Tissue‐dependent upregulation of rat uncoupling protein‐2 expression in response to fasting or cold

Boss, O., Samec, S., Dulloo, A. G., Seydoux, J., Muzzin, P., & Giacobino, J. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00755-2 · Cited by 218 · see citing works

Generating, Partitioning, Targeting and Functioning of Superoxide in Mitochondria

Liu, S. (1997) · Bioscience Reports · doi:10.1023/a:1027328510931 · Cited by 217 · see citing works

Free Fatty Acid-induced β-Cell Defects Are Dependent on Uncoupling Protein 2 Expression

Joseph, J. W., Koshkin, V., Saleh, M. C., Sivitz, W. I., Zhang, C.-Y., Lowell, B. B., Chan, C. B., & Wheeler, M. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409189200 · Cited by 206 · see citing works

The basal proton conductance of skeletal muscle mitochondria from transgenic mice overexpressing or lacking uncoupling protein-3

Cadenas, S., Echtay, K. S., Harper, J. A., Jekabsons, M. B., Buckingham, J. A., Grau, E., Abuin, A., Chapman, H., Clapham, J. C., & Brand, M. D. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109736200 · Cited by 199 · see citing works

Oxidative damage and phospholipid fatty acyl composition in skeletal muscle mitochondria from mice underexpressing or overexpressing uncoupling protein 3

BRAND, M. D., PAMPLONA, R., PORTERO-OTÍN, M., REQUENA, J. R., ROEBUCK, S. J., BUCKINGHAM, J. A., CLAPHAM, J. C., & CADENAS, S. (2002) · Biochemical Journal · doi:10.1042/bj20021077 · Cited by 184 · see citing works

Mitochondrial superoxide and aging: uncoupling-protein activity and superoxide production

Brand, M. D., Buckingham, J. A., Esteves, T. C., Green, K., Lambert, A. J., Miwa, S., Murphy, M. P., Pakay, J. L., Talbot, D. A., & Echtay, K. S. (2004) · Biochemical Society Symposia · doi:10.1042/bss0710203 · Cited by 182 · see citing works

Nutrient–secretion coupling in the pancreatic islet β-cell: recent advances

Rutter, G. A. (2001) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(01)00013-9 · Cited by 179 · see citing works

Mitochondrial ROS Metabolism: Modulation by Uncoupling Proteins

Casteilla, L., Rigoulet, M., & Pénicaud, L. (2001) · IUBMB Life · doi:10.1080/15216540152845984 · Cited by 170 · see citing works

Uncoupling proteins: the issues from a biochemist point of view

Klingenberg, M., & Echtay, K. S. (2001) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/s0005-2728(00)00242-5 · Cited by 168 · see citing works

Uncoupling proteins: their roles in adaptive thermogenesis and substrate metabolism reconsidered

Dulloo, A. G., & Samec, S. (2001) · British Journal Of Nutrition · doi:10.1079/bjn2001412 · Cited by 166 · see citing works

No Evidence for a Basal, Retinoic, or Superoxide-induced Uncoupling Activity of the Uncoupling Protein 2 Present in Spleen or Lung Mitochondria

Couplan, E., del Mar Gonzalez-Barroso, M., Alves-Guerra, M. C., Ricquier, D., Goubern, M., & Bouillaud, F. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202535200 · Cited by 161 · see citing works

Activation of the potato plant uncoupling mitochondrial protein inhibits reactive oxygen species generation by the respiratory chain

Kowaltowski, A. J., Costa, A. D. T., & Vercesi, A. E. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00231-2 · Cited by 156 · see citing works

Lipids up-regulate uncoupling protein 2 expression in rat hepatocytes

Cortez‐Pinto, H., Lin, H. Z., Yang, S. Q., Odwin-DaCosta, S., & Diehl, A. M. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70022-3 · Cited by 154 · see citing works

Uncoupling the agony from ecstasy

Mills, E., Banks, M. L., Sprague, J. E., & Finkel, T. (2003) · Nature · doi:10.1038/426403a · Cited by 148 · see citing works

The reactions catalysed by the mitochondrial uncoupling proteins UCP2 and UCP3

Esteves, T. C., & Brand, M. D. (2005) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2005.06.002 · Cited by 146 · see citing works

Cold‐induced mitochondrial uncoupling and expression of chicken UCP and ANT mRNA in chicken skeletal muscle

Toyomizu, M., Ueda, M., Sato, S., Seki, Y., Sato, K., & Akiba, Y. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03395-1 · Cited by 143 · see citing works

Uncoupling Protein-2 Participates in Cellular Defense against Oxidative Stress in Clonal β-Cells

Li, L., Skorpen, F., Egeberg, K. W., Jørgensen, I. H., & Grill, V. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4577 · Cited by 140 · see citing works

Superoxide Stimulates a Proton Leak in Potato Mitochondria That Is Related to the Activity of Uncoupling Protein

Considine, M. J., Goodman, M., Echtay, K. S., Laloi, M., Whelan, J., Brand, M. D., & Sweetlove, L. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301075200 · Cited by 137 · see citing works

Increased reactive oxygen species production with antisense oligonucleotides directed against uncoupling protein 2 in murine endothelial cells

Duval, C., Nègre‐Salvayre, A., Doglio, A., Salvayre, R., Pénicaud, L., & Casteilla, L. (2002) · Biochemistry and Cell Biology · doi:10.1139/o02-158 · Cited by 136 · see citing works

Production of endogenous matrix superoxide from mitochondrial complex I leads to activation of uncoupling protein 3

Talbot, D. A., Lambert, A. J., & Brand, M. D. (2004) · FEBS Letters · doi:10.1016/s0014-5793(03)01386-3 · Cited by 131 · see citing works

Uncoupling protein and ATP/ADP carrier increase mitochondrial proton conductance after cold adaptation of king penguins

Talbot, D. A., Duchamp, C., Rey, B., Hanuise, N., Rouanet, J. L., Sibille, B., & Brand, M. D. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.063768 · Cited by 126 · see citing works

The role of uncoupling protein 3 in fatty acid metabolism: protection against lipotoxicity?

Schrauwen, P. (2004) · Proceedings of The Nutrition Society · doi:10.1079/pns2003336 · Cited by 123 · see citing works

Mitochondrial functional state in clonal pancreatic β-cells exposed to free fatty acids.

Koshkin, V., Wang, X., Scherer, P. E., Chan, C. B., & Wheeler, M. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209709200 · Cited by 121 · see citing works

Uncoupling protein-2 deficiency promotes oxidant stress and delays liver regeneration in mice

Horimoto, M., Fülöp, P., Derdák, Z., Wands, J. R., & Baffy, G. (2004) · Hepatology · doi:10.1002/hep.20047 · Cited by 120 · see citing works

Mitochondrial Uncoupling Proteins in Energy Expenditure

Kozak, L. P., & Harper, M. (2000) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.20.1.339 · Cited by 114 · see citing works

Reconstitution of Recombinant Uncoupling Proteins

Jabůrek, M., & Garlid, K. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m302126200 · Cited by 111 · see citing works

Effects of Adenoviral Overexpression of Uncoupling Protein-2 and -3 on Mitochondrial Respiration in Insulinoma Cells**This work was supported by V.A. Medical Research Funds and NIH Grants DK-25295 and HD-29569.

Hong, Y., Fink, B. D., Dillon, J. S., & Sivitz, W. I. (2001) · Endocrinology · doi:10.1210/endo.142.1.7889 · Cited by 107 · see citing works

Mitochondrial uncoupling proteins – facts and fantasies

Ježek, P., Žáčková, M., Růžička, M., Škobisová, E., & Jabůrek, M. (2004) · Physiological Research · doi:10.33549/physiolres.930000.53.s199 · Cited by 105 · see citing works

Uncoupling protein-2: evidence for its function as a metabolic regulator

Saleh, M. C., Wheeler, M. B., & Chan, C. B. (2002) · Diabetologia · doi:10.1007/s00125-001-0737-x · Cited by 99 · see citing works

Cloning and functional characterization of an uncoupling protein homolog in hummingbirds

Vianna, C. R., Hagen, T., Zhang, C.-Y., Bachman, E. S., Boss, O., Gereben, B., Moriscot, A. S., Lowell, B. B., Bicudo, J. E. P. W., & Bianco, A. C. (2001) · Physiological Genomics · doi:10.1152/physiolgenomics.2001.5.3.137 · Cited by 92 · see citing works

Uncoupling protein 2 in the brain: distribution and function

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Hydroperoxy Fatty Acid Cycling Mediated by Mitochondrial Uncoupling Protein UCP2

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Astaxanthin-Rich Extract from the Green Alga Haematococcus pluvialis Lowers Plasma Lipid Concentrations and Enhances Antioxidant Defense in Apolipoprotein E Knockout Mice

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Free radicals generated by contracting muscle: By-products of metabolism or key regulators of muscle function?

Jackson, M. J. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.06.003 · Cited by 161 · see citing works

Mitochondria and Ca2+ signaling: old guests, new functions

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SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-δ

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The Adrenergic-Fatty Acid Load in Heart Failure

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The role of mitochondrial respiration in physiological and evolutionary adaptation

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The Role of Mitochondria in the Pathophysiology of Skeletal Muscle Insulin Resistance

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Induction of Endogenous Uncoupling Protein 3 Suppresses Mitochondrial Oxidant Emission during Fatty Acid-supported Respiration

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Response and adaptation of skeletal muscle to exercise - the role of reactive oxygen species

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Small Molecule Mitochondrial Uncouplers and Their Therapeutic Potential

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The regulation and turnover of mitochondrial uncoupling proteins

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The reactions catalysed by the mitochondrial uncoupling proteins UCP2 and UCP3

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Control of Reactive Oxygen Species Production in Contracting Skeletal Muscle

Jackson, M. J. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.3976 · Cited by 145 · see citing works

Mitochondria and calcium in health and disease

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Exploring Uncoupling Proteins and Antioxidant Mechanisms under Acute Cold Exposure in Brains of Fish

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Global liver gene expression differences in Nelore steers with divergent residual feed intake phenotypes

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Coevolution of body size and metabolic rate in vertebrates: a life‐history perspective

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Mitochondrial contributions to vascular endothelial dysfunction, arterial stiffness, and cardiovascular diseases

Kirkman, D. L., Robinson, A. T., Rossman, M. J., Seals, D. R., & Edwards, D. G. (2021) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00917.2020 · Cited by 146 · see citing works

Mitochondrial uncoupling proteins—What is their physiological role?

Echtay, K. S. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.08.011 · Cited by 338 · see citing works

The ‘Novel’‘Uncoupling’ Proteins UCP2 and UCP3: What Do They Really do? Pros and Cons for Suggested Functions

Nedergaard, J., & Cannon, B. (2003) · Experimental Physiology · doi:10.1113/eph8802502 · Cited by 226 · see citing works

Nutrition & Metabolism BioMed Central Review Uncoupling

Fisler, J. S., & Warden, C. H. (2006)

Uncoupling proteins, dietary fat and the metabolic syndrome

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UCP2 and UCP3 in muscle controlling body metabolism

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