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Stress induces tRNA cleavage by angiogenin in mammalian cells
Abstract
tRNAs play a central role in protein translation, acting as the carrier of amino acids. By cloning microRNAs, we unexpectedly obtained some tRNA fragments generated by tRNA cleavage in the anticodon loop. These tRNA fragments are present in many cell lines and different mouse tissues. In addition, various stress conditions can induce this tRNA cleavage event in mammalian cells. More importantly, angiogenin (ANG), a member of RNase A superfamily, appears to be the nuclease which cleaves tRNAs into tRNA halves in vitro and in vivo. These results imply that angiogenin plays an important physiological role in cell stress response, except for the known function of inducing angiogenesis.
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Cited by
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Goodarzi, H., Liu, X., Nguyen, H. C. B., Zhang, S., Fish, L., & Tavazoie, S. F. (2015) · Cell · doi:10.1016/j.cell.2015.02.053 · Cited by 949
RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage
Schaefer, M., Pollex, T., Hanna, K., Tuorto, F., Meusburger, M., Helm, M., & Lyko, F. (2010) · Genes & Development · doi:10.1101/gad.586710 · Cited by 746
Biogenesis and Function of Transfer RNA-Related Fragments (tRFs)
Kumar, P., Kuscu, C., & Dutta, A. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.05.004 · Cited by 511
Angiogenin-induced tRNA-derived Stress-induced RNAs Promote Stress-induced Stress Granule Assembly
Emara, M. M., Ivanov, P., Hickman, T., Dawra, N., Tisdale, S., Kedersha, N., Hu, G.-F., & Anderson, P. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.077560 · Cited by 500
Small RNAs Are Trafficked from the Epididymis to Developing Mammalian Sperm
Sharma, U., Sun, F., Conine, C. C., Reichholf, B., Kukreja, S., Herzog, V. A., Ameres, S. L., & Rando, O. J. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.06.023 · Cited by 429
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Metadata
- Authors
- Fu, H., Feng, J., Liu, Q., Sun, F., Tie, Y., Zhu, J., Xing, R., Sun, Z., & Zheng, X.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2008-12-27
- Volume
- 583
- Issue
- 2
- Pages
- 437-442
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2087463572
- Cited by
- 571
- References
- 0
- FWCI
- 4.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fu, H., Feng, J., Liu, Q., Sun, F., Tie, Y., Zhu, J., Xing, R., Sun, Z., & Zheng, X. (2009). Stress induces tRNA cleavage by angiogenin in mammalian cells. FEBS Letters. https://doi.org/10.1016/j.febslet.2008.12.043
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