The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
RNA methylation by Dnmt2 protects transfer RNAs against stress-induced cleavage
Open accessAbstract
Dnmt2 proteins are the most conserved members of the DNA methyltransferase enzyme family, but their substrate specificity and biological functions have been a subject of controversy. We show here that, in addition to tRNA Asp-GTC , tRNA Val-AAC and tRNA Gly-GCC are also methylated by Dnmt2. Drosophila Dnmt2 mutants showed reduced viability under stress conditions, and Dnmt2 relocalized to stress granules following heat shock. Strikingly, stress-induced cleavage of tRNAs was Dnmt2-dependent, and Dnmt2-mediated methylation protected tRNAs against ribonuclease cleavage. These results uncover a novel biological function of Dnmt2-mediated tRNA methylation, and suggest a role for Dnmt2 enzymes during the biogenesis of tRNA-derived small RNAs.
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Metadata
- Authors
- Schaefer, M., Pollex, T., Hanna, K., Tuorto, F., Meusburger, M., Helm, M., & Lyko, F.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2010-08-01
- Volume
- 24
- Issue
- 15
- Pages
- 1590-1595
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2067022150
- Cited by
- 746
- References
- 26
- Type
- posted content
- Language
- en
- Open access
- diamond
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