Cited by 42Histone Deacetylase Inhibitors ResearchInfluenza Virus Research StudiesCell death mechanisms and regulation

Influenza A virus‐induced caspase‐3 cleaves the histone deacetylase 6 in infected epithelial cells

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Husain, Matloob, Harrod, Kevin S.·2009·FEBS Letters

Abstract

Histone deacetylase 6 (HDAC6) is a multi‐substrate cytoplasmic enzyme that regulates many important biological processes. Recently, some reports have implicated HDAC6 in viral infection. However, nothing is known about its regulation in virus‐infected cells. The data presented here for the first time demonstrate the caspase‐3‐mediated cleavage of HDAC6 in influenza A virus (IAV)‐infected cells. HDAC6 polypeptide contains the caspase‐3 cleavage motif DMAD‐S at the C‐terminus, and is a caspase‐3 substrate. The cleavage removes most of the C‐terminal ubiquitin‐binding zinc finger domain from HDAC6, which could be significant for HDAC6's role in IAV‐induced apoptosis in infected cells.

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Crossref · 10.1016/j.febslet.2009.07.005

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  • Rhinovirus increases the binding of S. pneumoniae to bronchial epithelial cells by upregulating expression of PAF-r.

    “For example, rhinovirus increases the binding of S. pneumoniae to bronchial epithelial cells by upregulating expression of PAF-r (119).”

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Authors
Husain, M., & Harrod, K. S.
Affiliations
Lovelace Respiratory Research Institute (US)
Corresponding author
Husain, Matloob
Venue
FEBS Letters
Publisher
Wiley
Published
2009-07-11
Volume
583
Issue
15
Pages
2517-2520
ISSN
  • 0014-5793 (ISSN-L)
  • 1873-3468
OpenAlex
W2090375806
Cited by
42
References
21
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 3 · 2016: 9 · 2015: 1 · 2014: 1 · 2013: 3
FWCI
0.54
Type
journal article
Language
en
Open access
Locations
  • FEBS Letters (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
  • Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords
influenza A virus, HDAC6, caspase-3, proteolytic cleavage, viral infection, apoptosis, epithelial cells
MeSH terms
Histone Deacetylase 6, Animals, Cell Line, Epithelial Cells, Histone Deacetylases, Humans, Influenza A virus, Caspase 3

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