Influenza A virus‐induced caspase‐3 cleaves the histone deacetylase 6 in infected epithelial cells
Open accessAbstract
Histone deacetylase 6 (HDAC6) is a multi‐substrate cytoplasmic enzyme that regulates many important biological processes. Recently, some reports have implicated HDAC6 in viral infection. However, nothing is known about its regulation in virus‐infected cells. The data presented here for the first time demonstrate the caspase‐3‐mediated cleavage of HDAC6 in influenza A virus (IAV)‐infected cells. HDAC6 polypeptide contains the caspase‐3 cleavage motif DMAD‐S at the C‐terminus, and is a caspase‐3 substrate. The cleavage removes most of the C‐terminal ubiquitin‐binding zinc finger domain from HDAC6, which could be significant for HDAC6's role in IAV‐induced apoptosis in infected cells.
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- Authors
- Husain, M., & Harrod, K. S.
- Affiliations
- Lovelace Respiratory Research Institute (US)
- Corresponding author
- Husain, Matloob
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2009-07-11
- Volume
- 583
- Issue
- 15
- Pages
- 2517-2520
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2090375806
- Cited by
- 42
- References
- 21
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 3 · 2016: 9 · 2015: 1 · 2014: 1 · 2013: 3
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Histone Deacetylase Inhibitors Research
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- influenza A virus, HDAC6, caspase-3, proteolytic cleavage, viral infection, apoptosis, epithelial cells
- MeSH terms
- Histone Deacetylase 6, Animals, Cell Line, Epithelial Cells, Histone Deacetylases, Humans, Influenza A virus, Caspase 3
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