Function of tau protein in adult newborn neurons
Abstract
Levels of tau phosphorylation are high during the developmental period of intense neurite outgrowth, but decrease later. We here investigated whether tau protein plays a role in adult neurogenesis. First we demonstrate that new neurons generated in the subgranular zone express tau in a hyperphosphorylated form. Phospho‐tau expression colocalized with doublecortin but not with glial fibrillary acidic protein, Ki67 or calbindin. The same was observed in the subventricular zone. Tau knockout mice did not show a significant decrease in the number of doublecortin‐positive cells, although a deficit in migration was observed. These findings suggest that basal tau phosphorylation present in adult animals is in part due to neurogenesis, and from Tau knockout mice it seems that tau is involved in normal migration of new neurons.
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Genetic deletion studies indicate that endogenous tau participates in neuronal processes including cytoskeletal regulation, mitochondrial dynamics, synaptic plasticity, network activity, and DNA/RNA stability.
“Genetic deletion studies indicate that endogenous tau participates in a range of neuronal processes, including cytoskeletal regulation, mitochondrial dynamics, synaptic plasticity, network activity [10–22], and stability of DNA and RNA stability [23].”
From Tau Ablation Rewires Brain Cell Programs in Health and Restores Function in Disease (2026) · cites this paper as [13]
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Lee, V. M.-Y., Goedert, M., & Trojanowski, J. Q. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1121 · Cited by 2,480 · see citing works
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Roles of tau protein in health and disease
Guo, T., Noble, W., & Hanger, D. P. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1707-9 · Cited by 1,003 · see citing works
Arendt, T., Stieler, J. T., & Holzer, M. (2016) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2016.08.018 · Cited by 609 · see citing works
Tau in neurodegenerative disease
Gao, Y.-L., Wang, N., Sun, F.-R., Cao, X.-P., Zhang, W., & Yu, J.-T. (2018) · Annals of Translational Medicine · doi:10.21037/atm.2018.04.23 · Cited by 222 · see citing works
Alzheimer’s disease and hippocampal adult neurogenesis; exploring shared mechanisms
Hollands, C., Bartolotti, N., & Lazarov, O. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00178 · Cited by 160 · see citing works
Tau Ablation Rewires Brain Cell Programs in Health and Restores Function in Disease
Chimal-Juárez, E., Patel, H., Jury-Garfe, N., Dabin, L. C., Vidal, R., Kim, J., & Lasagna-Reeves, C. A. (2026) · bioRxiv · doi:10.64898/2026.05.12.724684
- Authors
- Fuster-Matanzo, A., de Barreda, E. G., Dawson, H. N., Vitek, M. P., Avila, J., & Hernández, F.
- Affiliations
- Consejo Superior de Investigaciones Científicas (ES)
- Duke University (US)
- Corresponding author
- Hernández, Félix
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2009-08-18
- Volume
- 583
- Issue
- 18
- Pages
- 3063-3068
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2096027030
- Cited by
- 57
- References
- 1
- Citations by year
- 2026: 3 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 8 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 9 · 2015: 4 · 2014: 1 · 2013: 2 · 2012: 4
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- DIGITAL.CSIC (Spanish National Research Council (CSIC)) (submittedVersion)
- Funders
- Comunidad de Madrid (NEURODEGMODELS-CM)
- Spanish Comisión Interministerial de Ciencia y Tecnologia
- CIBER on Neurodegeneration
- Fundación Ramón Areces
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- tau protein, tau phosphorylation, adult neurogenesis, subgranular zone, subventricular zone, doublecortin, neuronal migration, tau knockout mice, newborn neurons, neurite outgrowth
- MeSH terms
- Doublecortin Domain Proteins, Animals, Cell Movement, Cerebral Ventricles, Microtubule-Associated Proteins, Neurons, Neuropeptides, Phosphorylation, tau Proteins, Mice, Knockout, Mice, Neurogenesis
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