The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Klotho is a substrate for α‐, β‐ and γ‐secretase
Open accessAbstract
Klotho is an anti‐aging protein with different functions of the full‐length membrane protein and the secreted hormone‐like form. Using overexpression and knock‐down approaches as well as embryonic fibroblasts of knock‐out mice we present evidence that Klotho is shedded by the α‐secretases ADAM10 and 17 as well as by the β‐secretase β‐APP cleaving enzyme 1. The remaining membrane‐bound fragment is a substrate for regulated intramembrane proteolysis by γ‐secretase. Our data suggest that therapeutic approaches targeting these proteases should be carefully analyzed for potential side effects on Klotho‐mediated physiological processes.
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Cites
Suppression of Aging in Mice by the Hormone Klotho
Kurosu, H., Yamamoto, M., Clark, J. D., Pastor, J. V., Nandi, A., Gurnani, P., McGuinness, O. P., Chikuda, H., Yamaguchi, M., Kawaguchi, H., et al. (2005) · Science · doi:10.1126/science.1112766 · Cited by 1,935
Self-citationAugmented Wnt signaling in a mammalian model of accelerated aging
Liu, H., Fergusson, M. M., Castilho, R. M., Liu, J., Cao, L., Chen, J., Malide, D., Rovira, I. I., Schimel, D., Kuo, C. J., et al. (2007) · Science · doi:10.1126/science.1143578 · Cited by 755 · cited 1×
“One function of the secreted Kl is to antagonize wnt signaling [19], another the activation of the calcium channel TRPV5 [20].”
BackgroundPart-Time α-Secretases: The Functional Biology of ADAM 9, 10 and 17
Deuss, M., Reiss, K., & Hartmann, D. (2008) · Current Alzheimer Research · doi:10.2174/156720508783954686 · Cited by 98
Cited by
The Klotho proteins in health and disease
Kuro-o, M. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-018-0078-3 · Cited by 707
Self-citationHu, M. C., Shiizaki, K., Kuro-o, M., & Moe, O. W. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-030212-183727 · Cited by 587
Self-citationThe Many Substrates of Presenilin/γ-Secretase
Haapasalo, A., & Kovacs, D. M. (2011) · Journal of Alzheimer's Disease · doi:10.3233/jad-2011-101065 · Cited by 458
Animal Models of Alzheimer Disease
LaFerla, F. M., & Green, K. N. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006320 · Cited by 419
ADAM-17: the enzyme that does it all
Gooz, M. (2010) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409231003628015 · Cited by 377
Metadata
- Authors
- Bloch, L., Sineshchekova, O., Reichenbach, D., Reiss, K., Saftig, P., Kuro-o, M., & Kaether, C.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2009-09-06
- Volume
- 583
- Issue
- 19
- Pages
- 3221-3224
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2049720707
- Cited by
- 243
- References
- 3
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bloch, L., Sineshchekova, O., Reichenbach, D., Reiss, K., Saftig, P., Kuro-o, M., & Kaether, C. (2009). Klotho is a substrate for α‐, β‐ and γ‐secretase. FEBS Letters. https://doi.org/10.1016/j.febslet.2009.09.009
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