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The Many Substrates of Presenilin/γ-Secretase

Haapasalo, Annakaisa, Kovacs, Dora M.·2011·Journal of Alzheimer's Disease

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  1. [1]De Strooper B Annaert W Cupers P Saftig P Craessaerts K Mumm JS Schroeter EH Schrijvers V Wolfe MS Ray WJ Goate A Kopan R 1999 A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain Nature 398 518 522 10206645
  2. [2]Beel AJ Sanders CR 2008 Substrate specificity of gamma-secretase and other intramembrane proteases Cell Mol Life Sci 65 1311 1334 18239854 PMC2569971
  3. [3]Spasic D Annaert W 2008 Building gamma-secretase: the bits and pieces J Cell Sci 121 413 420 18256384
  4. [4]Selkoe DJ Wolfe MS 2007 Presenilin: running with scissors in the membrane Cell 131 215 221 17956719
  5. [5]Edbauer D Winkler E Regula JT Pesold B Steiner H Haass C 2003 Reconstitution of gamma-secretase activity Nat Cell Biol 5 486 488 12679784
  6. [6]Weihofen A Martoglio B 2003 Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptides Trends Cell Biol 13 71 78 12559757
  7. [7]Brown MS Ye J Rawson RB Goldstein JL 2000 Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans Cell 100 391 398 10693756
  8. [8]Strisovsky K Sharpe HJ Freeman M 2009 Sequence-specific intramembrane proteolysis: identification of a recognition motif in rhomboid substrates Mol Cell 36 1048 1059 20064469 PMC2941825
  9. [9]Vetrivel KS Thinakaran G 2006 Amyloidogenic processing of beta-amyloid precursor protein in intracellular compartments Neurology 66 S69 S73 16432149
  10. [10]Struhl G Adachi A 2000 Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins Mol Cell 6 625 636 11030342
  11. [11]Kopan R Ilagan MX 2004 Gamma-secretase: proteasome of the membrane? Nat Rev Mol Cell Biol 5 499 504 15173829
  12. [12]Masliah E Westland CE Rockenstein EM Abraham CR Mallory M Veinberg I Sheldon E Mucke L 1997 Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo Neuroscience 78 135 146 9135095
  13. [13]Priller C Bauer T Mitteregger G Krebs B Kretzschmar HA Herms J 2006 Synapse formation and function is modulated by the amyloid precursor protein J Neurosci 26 7212 7221 16822978 PMC6673945
  14. [14]Lazarov O Morfini GA Lee EB Farah MH Szodorai A DeBoer SR Koliatsos VE Kins S Lee VM Wong PC Price DL Brady ST Sisodia SS 2005 Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited J Neurosci 25 2386 2395 15745965 PMC6726084
  15. [15]LeBlanc AC Kovacs DM Chen HY Villare F Tykocinski M Autilio-Gambetti L Gambetti P 1992 Role of amyloid precursor protein (APP): study with antisense transfection of human neuroblastoma cells J Neurosci Res 31 635 645 1578514
  16. [16]Coulson EJ Barrett GL Storey E Bartlett PF Beyreuther K Masters CL 1997 Down-regulation of the amyloid protein precursor of Alzheimer’s disease by antisense oligonucleotides reduces neuronal adhesion to specific substrata Brain Res 770 72 80 9372205
  17. [17]Soba P Eggert S Wagner K Zentgraf H Siehl K Kreger S Lower A Langer A Merdes G Paro R Masters CL Muller U Kins S Beyreuther K 2005 Homo- and heterodimerization of APP family members promotes intercellular adhesion EMBO J 24 3624 3634 16193067 PMC1276707
  18. [18]Hoe HS Lee KJ Carney RS Lee J Markova A Lee JY Howell BW Hyman BT Pak DT Bu G Rebeck GW 2009 Interaction of reelin with amyloid precursor protein promotes neurite outgrowth J Neurosci 29 7459 7473 19515914 PMC2759694
  19. [19]Buxbaum JD Liu KN Luo Y Slack JL Stocking KL Peschon JJ Johnson RS Castner BJ Cerretti DP Black RA 1998 Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor J Biol Chem 273 27765 27767 9774383
  20. [20]Lopez-Perez E Zhang Y Frank SJ Creemers J Seidah N Checler F 2001 Constitutive alpha-secretase cleavage of the beta-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10 J Neurochem 76 1532 1539 11238737
  21. [21]Hiltunen M van Groen T Jolkkonen J 2009 Functional roles of amyloid-beta protein precursor and amyloid-beta peptides: evidence from experimental studies J Alzheimers Dis 18 401 412 19584429
  22. [23]Mattson MP 2004 Pathways towards and away from Alzheimer’s disease Nature 430 631 639 15295589 PMC3091392
  23. [24]Kimberly WT Zheng JB Guenette SY Selkoe DJ 2001 The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner J Biol Chem 276 40288 40292 11544248
  24. [26]von Rotz RC Kohli BM Bosset J Meier M Suzuki T Nitsch RM Konietzko U 2004 The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor J Cell Sci 117 4435 4448 15331662
  25. [27]Baek SH Ohgi KA Rose DW Koo EH Glass CK Rosenfeld MG 2002 Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein Cell 110 55 67 12150997
  26. [28]Cao X Sudhof TC 2004 Dissection of amyloid-beta precursor protein-dependent transcriptional transactivation J Biol Chem 279 24601 24611 15044485
  27. [29]Pardossi-Piquard R Petit A Kawarai T Sunyach C Alves da Costa C Vincent B Ring S D’Adamio L Shen J Muller U St George Hyslop P Checler F 2005 Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP Neuron 46 541 554 15944124
  28. [30]Ozaki T Li Y Kikuchi H Tomita T Iwatsubo T Nakagawara A 2006 The intracellular domain of the amyloid precursor protein (AICD) enhances the p53-mediated apoptosis Biochem Biophys Res Commun 351 57 63 17054906
  29. [32]Zhang YW Wang R Liu Q Zhang H Liao FF Xu H 2007 Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression Proc Natl Acad Sci U S A 104 10613 10618 17556541 PMC1888796
  30. [33]Hebert SS Serneels L Tolia A Craessaerts K Derks C Filippov MA Muller U De Strooper B 2006 Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes EMBO Rep 7 739 745 16729020 PMC1500829
  31. [34]Waldron E Isbert S Kern A Jaeger S Martin AM Hebert SS Behl C Weggen S De Strooper B Pietrzik CU 2008 Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcription Exp Cell Res 314 2419 2433 18559276
  32. [35]Ring S Weyer SW Kilian SB Waldron E Pietrzik CU Filippov MA Herms J Buchholz C Eckman CB Korte M Wolfer DP Muller UC 2007 The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice J Neurosci 27 7817 7826 17634375 PMC6672885
  33. [36]Goodger ZV Rajendran L Trutzel A Kohli BM Nitsch RM Konietzko U 2009 Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway J Cell Sci 122 3703 3714 19773363
  34. [37]Ghosal K Vogt DL Liang M Shen Y Lamb BT Pimplikar SW 2009 Alzheimer’s disease-like pathological features in transgenic mice expressing the APP intracellular domain Proc Natl Acad Sci U S A 106 18367 18372 19837693 PMC2762847
  35. [38]Hussain I Powell D Howlett DR Tew DG Meek TD Chapman C Gloger IS Murphy KE Southan CD Ryan DM Smith TS Simmons DL Walsh FS Dingwall C Christie G 1999 Identification of a novel aspartic protease (Asp 2) as beta-secretase Mol Cell Neurosci 14 419 427 10656250
  36. [39]Sinha S Anderson JP Barbour R Basi GS Caccavello R Davis D Doan M Dovey HF Frigon N Hong J Jacobson-Croak K Jewett N Keim P Knops J Lieberburg I Power M Tan H Tatsuno G Tung J Schenk D Seubert P Suomensaari SM Wang S Walker D Zhao J McConlogue L John V 1999 Purification and cloning of amyloid precursor protein beta-secretase from human brain Nature 402 537 540 10591214
  37. [41]Yan R Bienkowski MJ Shuck ME Miao H Tory MC Pauley AM Brashier JR Stratman NC Mathews WR Buhl AE Carter DB Tomasselli AG Parodi LA Heinrikson RL Gurney ME 1999 Membrane-anchored aspartyl protease with Alzheimer’s disease beta-secretase activity Nature 402 533 537 10591213
  38. [42]Nalivaeva NN Fisk LR Belyaev ND Turner AJ 2008 Amyloid-degrading enzymes as therapeutic targets in Alzheimer’s disease Curr Alzheimer Res 5 212 224 18393806
  39. [43]Miners JS Baig S Palmer J Palmer LE Kehoe PG Love S 2008 Abeta-degrading enzymes in Alzheimer’s disease Brain Pathol 18 240 252 18363935 PMC8095507
  40. [44]Zhao J Fu Y Yasvoina M Shao P Hitt B O’Connor T Logan S Maus E Citron M Berry R Binder L Vassar R 2007 Beta-site amyloid precursor protein cleaving enzyme 1 levels become elevated in neurons around amyloid plaques: implications for Alzheimer’s disease pathogenesis J Neurosci 27 3639 3649 17409228 PMC6672403
  41. [45]Tanzi RE Bertram L 2005 Twenty years of the Alzheimer’s disease amyloid hypothesis: a genetic perspective Cell 120 545 555 15734686
  42. [46]De Strooper B Saftig P Craessaerts K Vanderstichele H Guhde G Annaert W Von Figura K Van Leuven F 1998 Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein Nature 391 387 390 9450754
  43. [47]Xia W Zhang J Ostaszewski BL Kimberly WT Seubert P Koo EH Shen J Selkoe DJ 1998 Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and golgi Biochemistry 37 16465 16471 9843412
  44. [48]Chen F Yang DS Petanceska S Yang A Tandon A Yu G Rozmahel R Ghiso J Nishimura M Zhang DM Kawarai T Levesque G Mills J Levesque L Song YQ Rogaeva E Westaway D Mount H Gandy S St George-Hyslop P Fraser PE 2000 Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells J Biol Chem 275 36794 36802 10962005
  45. [49]Wolfe MS De Los Angeles J Miller DD Xia W Selkoe DJ 1999 Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer’s disease Biochemistry 38 11223 11230 10471271
  46. [50]Yu G Nishimura M Arawaka S Levitan D Zhang L Tandon A Song YQ Rogaeva E Chen F Kawarai T Supala A Levesque L Yu H Yang DS Holmes E Milman P Liang Y Zhang DM Xu DH Sato C Rogaev E Smith M Janus C Zhang Y Aebersold R Farrer LS Sorbi S Bruni A Fraser P St George-Hyslop P 2000 Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing Nature 407 48 54 10993067
  47. [51]Goutte C Tsunozaki M Hale VA Priess JR 2002 APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos Proc Natl Acad Sci U S A 99 775 779 11792846 PMC117381
  48. [52]Lee SF Shah S Li H Yu C Han W Yu G 2002 Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch J Biol Chem 277 45013 45019 12297508
  49. [53]Francis R McGrath G Zhang J Ruddy DA Sym M Apfeld J Nicoll M Maxwell M Hai B Ellis MC Parks AL Xu W Li J Gurney M Myers RL Himes CS Hiebsch R Ruble C Nye JS Curtis D 2002 aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation Dev Cell 3 85 97 12110170
  50. [54]Steiner H Winkler E Edbauer D Prokop S Basset G Yamasaki A Kostka M Haass C 2002 PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin J Biol Chem 277 39062 39065 12198112
  51. [55]Haass C Steiner H 2002 Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin pro teases Trends Cell Biol 12 556 562 12495843
  52. [56]De Strooper B 2003 Aph-1, Pen-2, and Nicastrin with presenilin generate an active gamma-secretase complex Neuron 38 9 12 12691659
  53. [57]Wolfe MS Xia W Ostaszewski BL Diehl TS Kimberly WT Selkoe DJ 1999 Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity Nature 398 513 517 10206644
  54. [58]Kimberly WT Xia W Rahmati T Wolfe MS Selkoe DJ 2000 The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation J Biol Chem 275 3173 3178 10652302
  55. [59]Shah S Lee SF Tabuchi K Hao YH Yu C LaPlant Q Ball H Dann CE 3rd Sudhof T Yu G 2005 Nicastrin functions as a gamma-secretase-substrate receptor Cell 122 435 447 16096062
  56. [60]Chavez-Gutierrez L Tolia A Maes E Li T Wong PC de Strooper B 2008 Glu(332) in the Nicastrin ectodomain is essential for gamma-secretase complex maturation but not for its activity J Biol Chem 283 20096 20105 18502756
  57. [61]Zhao G Liu Z Ilagan MX Kopan R 2010 Gamma-secretase composed of PS1/Pen2/Aph1 a can cleave notch and amyloid precursor protein in the absence of nicastrin J Neurosci 30 1648 1656 20130175 PMC2853942
  58. [62]Dries DR Shah S Han YH Yu C Yu S Shearman MS Yu G 2009 Glu-333 of nicastrin directly participates in gamma-secretase activity J Biol Chem 284 29714 29724 19729449 PMC2785603
  59. [63]Serneels L Van Biervliet J Craessaerts K Dejaegere T Horre K Van Houtvin T Esselmann H Paul S Schafer MK Berezovska O Hyman BT Sprangers B Sciot R Moons L Jucker M Yang Z May PC Karran E Wiltfang J D’Hooge R De Strooper B 2009 Gamma-secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer’s disease Science 324 639 642 19299585 PMC2740474
  60. [64]Chen AC Guo LY Ostaszewski BL Selkoe DJ LaVoie MJ 2010 Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates J Biol Chem 285 11378 11391 20145246 PMC2857016
  61. [65]Thinakaran G Borchelt DR Lee MK Slunt HH Spitzer L Kim G Ratovitsky T Davenport F Nordstedt C Seeger M Hardy J Levey AI Gandy SE Jenkins NA Copeland NG Price DL Sisodia SS 1996 Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo Neuron 17 181 190 8755489
  62. [66]Sato T Diehl TS Narayanan S Funamoto S Ihara Y De Strooper B Steiner H Haass C Wolfe MS 2007 Active gamma-secretase complexes contain only one of each component J Biol Chem 282 33985 33993 17911105
  63. [67]Vetrivel KS Zhang YW Xu H Thinakaran G 2006 Pathological and physiological functions of presenilins Mol Neurodegener 1 4 16930451 PMC1513131
  64. [68]Serneels L Dejaegere T Craessaerts K Horre K Jorissen E Tousseyn T Hebert S Coolen M Martens G Zwijsen A Annaert W Hartmann D De Strooper B 2005 Differential contribution of the three Aph1 genes to gamma-secretase activity in vivo Proc Natl Acad Sci U S A 102 1719 1724 15665098 PMC547495
  65. [71]Lai MT Chen E Crouthamel MC DiMuzio-Mower J Xu M Huang Q Price E Register RB Shi XP Donoviel DB Bernstein A Hazuda D Gardell SJ Li YM 2003 Presenilin-1 and presenilin-2 exhibit distinct yet overlapping gamma-secretase activities J Biol Chem 278 22475 22481 12684521
  66. [72]Mastrangelo P Mathews PM Chishti MA Schmidt SD Gu Y Yang J Mazzella MJ Coomaraswamy J Horne P Strome B Pelly H Levesque G Ebeling C Jiang Y Nixon RA Rozmahel R Fraser PE St George-Hyslop P Carlson GA Westaway D 2005 Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases Proc Natl Acad Sci U S A 102 8972 8977 15951428 PMC1149500
  67. [73]Shen J Bronson RT Chen DF Xia W Selkoe DJ Tonegawa S 1997 Skeletal and CNS defects in presenilin-1-deficient mice Cell 89 629 639 9160754
  68. [74]Herreman A Hartmann D Annaert W Saftig P Craessaerts K Serneels L Umans L Schrijvers V Checler F Vanderstichele H Baekelandt V Dressel R Cupers P Huylebroeck D Zwijsen A Van Leuven F De Strooper B 1999 Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency Proc Natl Acad Sci U S A 96 11872 11877 10518543 PMC18379
  69. [75]Maetzel D Denzel S Mack B Canis M Went P Benk M Kieu C Papior P Baeuerle PA Munz M Gires O 2009 Nuclear signalling by tumour-associated antigen EpCAM Nat Cell Biol 11 162 171 19136966
  70. [76]Huysseune S Kienlen-Campard P Hebert S Tasiaux B Leroy K Devuyst O Brion JP De Strooper B Octave JN 2009 Epigenetic control of aquaporin 1 expression by the amyloid precursor protein FASEB J 23 4158 4167 19687153
  71. [77]Zhou S Zhou H Walian PJ Jap BK 2005 CD147 is a regulatory subunit of the gamma-secretase complex in Alzheimer’s disease amyloid beta-peptide production Proc Natl Acad Sci U S A 102 7499 7504 15890777 PMC1103709
  72. [78]Chen F Hasegawa H Schmitt-Ulms G Kawarai T Bohm C Katayama T Gu Y Sanjo N Glista M Rogaeva E Wakutani Y Pardossi-Piquard R Ruan X Tandon A Checler F Marambaud P Hansen K Westaway D St George-Hyslop P Fraser P 2006 TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity Nature 440 1208 1212 16641999
  73. [79]Verdile G Gandy SE Martins RN 2007 The role of pre-senilin and its interacting proteins in the biogenesis of Alzheimer’s beta amyloid Neurochem Res 32 609 623 16944319 PMC1832151
  74. [80]Huovila AP Turner AJ Pelto-Huikko M Karkkainen I Ortiz RM 2005 Shedding light on ADAM metalloproteinases Trends Biochem Sci 30 413 422 15949939
  75. [81]Schlondorff J Becherer JD Blobel CP 2000 Intracellular maturation and localization of the tumour necrosis factor alpha convertase (TACE) Biochem J 347 Pt 1 131 138 10727411 PMC1220940
  76. [82]Jolly-Tornetta C Wolf BA 2000 Protein kinase C regulation of intracellular and cell surface amyloid precursor protein (APP) cleavage in CHO695 cells Biochemistry 39 15282 15290 11106509
  77. [83]Skovronsky DM Moore DB Milla ME Doms RW Lee VM 2000 Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network J Biol Chem 275 2568 2575 10644715
  78. [84]Stephens DJ Austen BM 1996 Metabolites of the beta-amyloid precursor protein generated by beta-secretase localise to the trans-golgi network and late endosome in 293 cells J Neurosci Res 46 211 225 8915898
  79. [85]Daugherty BL Green SA 2001 Endosomal sorting of amyloid precursor protein-P-selectin chimeras influences secretase processing Traffic 2 908 916 11737828
  80. [86]Walter J Fluhrer R Hartung B Willem M Kaether C Capell A Lammich S Multhaup G Haass C 2001 Phosphorylation regulates intracellular trafficking of beta-secretase J Biol Chem 276 14634 14641 11278841
  81. [87]Chyung JH Selkoe DJ 2003 Inhibition of receptor-mediated endocytosis demonstrates generation of amyloid beta-protein at the cell surface J Biol Chem 278 51035 51043 14525989
  82. [88]Kinoshita A Fukumoto H Shah T Whelan CM Irizarry MC Hyman BT 2003 Demonstration by FRET of BACE interaction with the amyloid precursor protein at the cell surface and in early endosomes J Cell Sci 116 3339 3346 12829747
  83. [89]Kim SH Yin YI Li YM Sisodia SS 2004 Evidence that assembly of an active gamma-secretase complex occurs in the early compartments of the secretory pathway J Biol Chem 279 48615 48619 15456788
  84. [90]Vetrivel KS Cheng H Lin W Sakurai T Li T Nukina N Wong PC Xu H Thinakaran G 2004 Association of gamma-secretase with lipid rafts in post-golgi and endosome membranes J Biol Chem 279 44945 44954 15322084 PMC1201506
  85. [91]Pasternak SH Bagshaw RD Guiral M Zhang S Ackerley CA Pak BJ Callahan JW Mahuran DJ 2003 Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane J Biol Chem 278 26687 26694 12736250
  86. [92]Jutras I Laplante A Boulais J Brunet S Thinakaran G Desjardins M 2005 Gamma-secretase is a functional component of phagosomes J Biol Chem 280 36310 36317 16103123
  87. [93]Fukumori A Okochi M Tagami S Jiang J Itoh N Nakayama T Yanagida K Ishizuka-Katsura Y Morihara T Kamino K Tanaka T Kudo T Tanii H Ikuta A Haass C Takeda M 2006 Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct Biochemistry 45 4907 4914 16605258
  88. [94]Chyung JH Raper DM Selkoe DJ 2005 Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage J Biol Chem 280 4383 4392 15569674
  89. [96]Carey RM Balcz BA Lopez-Coviella I Slack BE 2005 Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid beta protein BMC Cell Biol 6 30 16095541 PMC1208872
  90. [97]Cataldo AM Barnett JL Pieroni C Nixon RA 1997 Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer’s disease: neuropathologic evidence for a mechanism of increased beta-amyloidogenesis J Neurosci 17 6142 6151 9236226 PMC6568334
  91. [98]Cataldo AM Peterhoff CM Troncoso JC Gomez-Isla T Hyman BT Nixon RA 2000 Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer’s disease and Down syndrome: differential effects of APOE genotype and presenilin mutations Am J Pathol 157 277 286 10880397 PMC1850219
  92. [99]Huse JT Pijak DS Leslie GJ Lee VM Doms RW 2000 Maturation and endosomal targeting of beta-site amyloid precursor protein-cleaving enzyme. The Alzheimer’s disease beta-secretase J Biol Chem 275 33729 33737 10924510
  93. [100]Zhang M Haapasalo A Kim DY Ingano LA Pettingell WH Kovacs DM 2006 Presenilin/gamma-secretase activity regulates protein clearance from the endocytic recycling compartment FASEB J 20 1176 1178 16645046
  94. [101]Kaether C Schmitt S Willem M Haass C 2006 Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface Traffic 7 408 415 16536739
  95. [102]Urra S Escudero CA Ramos P Lisbona F Allende E Covarrubias P Parraguez JI Zampieri N Chao MV Annaert W Bronfman FC 2007 TrkA receptor activation by nerve growth factor induces shedding of the p75 neurotrophin receptor followed by endosomal gamma-secretase-mediated release of the p75 intracellular domain J Biol Chem 282 7606 7615 17215246
  96. [103]Vaccari T Lu H Kanwar R Fortini ME Bilder D 2008 Endosomal entry regulates Notch receptor activation in Drosophila melanogaster J Cell Biol 180 755 762 18299346 PMC2265571
  97. [104]Gupta-Rossi N Six E LeBail O Logeat F Chastagner P Olry A Israel A Brou C 2004 Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor J Cell Biol 166 73 83 15240571 PMC2172142
  98. [106]Querfurth HW LaFerla FM 2010 Alzheimer’s disease N Engl J Med 362 329 344 20107219
  99. [108]Kim DY Carey BW Wang H Ingano LA Binshtok AM Wertz MH Pettingell WH He P Lee VM Woolf CJ Kovacs DM 2007 BACE1 regulates voltage-gated sodium channels and neuronal activity Nat Cell Biol 9 755 764 17576410 PMC2747787
  100. [109]Araki Y Miyagi N Kato N Yoshida T Wada S Nishimura M Komano H Yamamoto T De Strooper B Yamamoto K Suzuki T 2004 Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation J Biol Chem 279 24343 24354 15037614
  101. [110]Okochi M Steiner H Fukumori A Tanii H Tomita T Tanaka T Iwatsubo T Kudo T Takeda M Haass C 2002 Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1 EMBO J 21 5408 5416 12374741 PMC129073
  102. [111]Walsh DM Fadeeva JV LaVoie MJ Paliga K Eggert S Kimberly WT Wasco W Selkoe DJ 2003 gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins Biochemistry 42 6664 6673 12779321
  103. [112]Hemming ML Elias JE Gygi SP Selkoe DJ 2008 Proteomic profiling of gamma-secretase substrates and mapping of substrate requirements PLoS Biol 6 e257 18942891 PMC2570425
  104. [113]McCarthy JV Twomey C Wujek P 2009 Presenilin-dependent regulated intramembrane proteolysis and gamma-secretase activity Cell Mol Life Sci 66 1534 1555 19189053 PMC11131470
  105. [114]Mumm JS Schroeter EH Saxena MT Griesemer A Tian X Pan DJ Ray WJ Kopan R 2000 A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1 Mol Cell 5 197 206 10882062
  106. [115]Nakahara S Saito T Kondo N Moriwaki K Noda K Ihara S Takahashi M Ide Y Gu J Inohara H Katayama T Tohyama M Kubo T Taniguchi N Miyoshi E 2006 A secreted type of beta1,6 N-acetylglucosaminyltransferase V (GnT-V), a novel angiogenesis inducer, is regulated by gamma-secretase FASEB J 20 2451 2459 17142794
  107. [116]Meyer EL Strutz N Gahring LC Rogers SW 2003 Glutamate receptor subunit 3 is modified by site-specific limited proteolysis including cleavage by gamma-secretase J Biol Chem 278 23786 23796 12700243
  108. [117]Scheinfeld MH Ghersi E Laky K Fowlkes BJ D’Adamio L 2002 Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription J Biol Chem 277 44195 44201 12228233
  109. [118]Minopoli G de Candia P Bonetti A Faraonio R Zambrano N Russo T 2001 The beta-amyloid precursor protein functions as a cytosolic anchoring site that prevents Fe65 nuclear translocation J Biol Chem 276 6545 6550 11085987
  110. [119]Okamoto I Kawano Y Murakami D Sasayama T Araki N Miki T Wong AJ Saya H 2001 Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway J Cell Biol 155 755 762 11714729 PMC2150876
  111. [120]Taniguchi Y Kim SH Sisodia SS 2003 Presenilin-dependent “gamma-secretase” processing of deleted in colorectal cancer (DCC) J Biol Chem 278 30425 30428 12840034
  112. [121]Schroeter EH Kisslinger JA Kopan R 1998 Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain Nature 393 382 386 9620803
  113. [122]Saxena MT Schroeter EH Mumm JS Kopan R 2001 Murine notch homologs (N1–4) undergo presenilin-dependent proteolysis J Biol Chem 276 40268 40273 11518718
  114. [123]Shimizu K Chiba S Hosoya N Kumano K Saito T Kurokawa M Kanda Y Hamada Y Hirai H 2000 Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2 Mol Cell Biol 20 6913 6922 10958687 PMC88767
  115. [124]Mizutani T Taniguchi Y Aoki T Hashimoto N Honjo T 2001 Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members Proc Natl Acad Sci U S A 98 9026 9031 11459941 PMC55367
  116. [125]Fiuza UM Arias AM 2007 Cell and molecular biology of Notch J Endocrinol 194 459 474 17761886
  117. [126]Ikeuchi T Sisodia SS 2003 The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent “gamma-secretase” cleavage J Biol Chem 278 7751 7754 12551931
  118. [127]LaVoie MJ Selkoe DJ 2003 The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments J Biol Chem 278 34427 34437 12826675
  119. [128]Bland CE Kimberly P Rand MD 2003 Notch-induced proteolysis and nuclear localization of the Delta ligand J Biol Chem 278 13607 13610 12591935
  120. [129]Six E Ndiaye D Laabi Y Brou C Gupta-Rossi N Israel A Logeat F 2003 The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase Proc Natl Acad Sci U S A 100 7638 7643 12794186 PMC164639
  121. [130]Marambaud P Shioi J Serban G Georgakopoulos A Sarner S Nagy V Baki L Wen P Efthimiopoulos S Shao Z Wisniewski T Robakis NK 2002 A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions EMBO J 21 1948 1956 11953314 PMC125968
  122. [131]Parisiadou L Fassa A Fotinopoulou A Bethani I Efthimiopoulos S 2004 Presenilin 1 and cadherins: stabilization of cell-cell adhesion and proteolysis-dependent regulation of transcription Neurodegener Dis 1 184 191 16908988
  123. [132]Ferber EC Kajita M Wadlow A Tobiansky L Niessen C Ariga H Daniel J Fujita Y 2008 A role for the cleaved cytoplasmic domain of E-cadherin in the nucleus J Biol Chem 283 12691 12700 18356166 PMC2442316
  124. [133]Marambaud P Wen PH Dutt A Shioi J Takashima A Siman R Robakis NK 2003 A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations Cell 114 635 645 13678586
  125. [134]Anders L Mertins P Lammich S Murgia M Hartmann D Saftig P Haass C Ullrich A 2006 Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin’s transcriptional activity Mol Cell Biol 26 3917 3934 16648485 PMC1489012
  126. [135]Haapasalo A Kim DY Carey BW Turunen MK Pettingell WH Kovacs DM 2007 Presenilin/gamma-secretase-mediated cleavage regulates association of leukocyte-common antigen-related (LAR) receptor tyrosine phosphatase with beta-catenin J Biol Chem 282 9063 9072 17259169
  127. [136]Louvi A Artavanis-Tsakonas S 2006 Notch signalling in vertebrate neural development Nat Rev Neurosci 7 93 102 16429119
  128. [137]Linggi B Cheng QC Rao AR Carpenter G 2006 The ErbB-4 s80 intracellular domain is a constitutively active tyrosine kinase Oncogene 25 160 163 16170367
  129. [138]Srinivasan R Gillett CE Barnes DM Gullick WJ 2000 Nuclear expression of the c-erbB-4/HER-4 growth factor receptor in invasive breast cancers Cancer Res 60 1483 1487 10749108
  130. [139]Ni CY Murphy MP Golde TE Carpenter G 2001 Gamma-secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase Science 294 2179 2181 11679632
  131. [140]Lee HJ Jung KM Huang YZ Bennett LB Lee JS Mei L Kim TW 2002 Presenilin-dependent gamma-secretase-like intramembrane cleavage of ErbB4 J Biol Chem 277 6318 6323 11741961
  132. [141]Williams CC Allison JG Vidal GA Burow ME Beckman BS Marrero L Jones FE 2004 The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone J Cell Biol 167 469 478 15534001 PMC2172499
  133. [142]Vidal GA Naresh A Marrero L Jones FE 2005 Presenilin-dependent gamma-secretase processing regulates multiple ERBB4/HER4 activities J Biol Chem 280 19777 19783 15746097
  134. [143]Lai C Feng L 2004 Implication of gamma-secretase in neuregulin-induced maturation of oligodendrocytes Biochem Biophys Res Commun 314 535 542 14733940
  135. [144]Sardi SP Murtie J Koirala S Patten BA Corfas G 2006 Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain Cell 127 185 197 17018285
  136. [145]Bu G Cam J Zerbinatti C 2006 LRP in amyloid-beta production and metabolism Ann N Y Acad Sci 1086 35 53 17185504
  137. [146]Polavarapu R An J Zhang C Yepes M 2008 Regulated intramembrane proteolysis of the low-density lipoprotein receptor-related protein mediates ischemic cell death Am J Pathol 172 1355 1362 18403601 PMC2329844
  138. [147]Majdan M Lachance C Gloster A Aloyz R Zeindler C Bamji S Bhakar A Belliveau D Fawcett J Miller FD Barker PA 1997 Transgenic mice expressing the intra-cellular domain of the p75 neurotrophin receptor undergo neuronal apoptosis J Neurosci 17 6988 6998 9278534 PMC6573268
  139. [148]Kenchappa RS Zampieri N Chao MV Barker PA Teng HK Hempstead BL Carter BD 2006 Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons Neuron 50 219 232 16630834
  140. [149]Yaar M Zhai S Pilch PF Doyle SM Eisenhauer PB Fine RE Gilchrest BA 1997 Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis. A possible mechanism for Alzheimer’s disease J Clin Invest 100 2333 2340 9410912 PMC508430
  141. [150]Costantini C Rossi F Formaggio E Bernardoni R Cecconi D Della-Bianca V 2005 Characterization of the signaling pathway downstream p75 neurotrophin receptor involved in beta-amyloid peptide-dependent cell death J Mol Neurosci 25 141 156 15784962
  142. [151]Yan Z Feng J 2004 Alzheimer’s disease: interactions between cholinergic functions and beta-amyloid Curr Alzheimer Res 1 241 248 15975053
  143. [152]Wu CK Thal L Pizzo D Hansen L Masliah E Geula C 2005 Apoptotic signals within the basal forebrain cholin-ergic neurons in Alzheimer’s disease Exp Neurol 195 484 496 16085017
  144. [153]Schliebs R 2005 Basal forebrain cholinergic dysfunction in Alzheimer’s disease – interrelationship with beta-amyloid, inflammation and neurotrophin signaling Neurochem Res 30 895 908 16187224
  145. [154]Yeo TT Chua-Couzens J Butcher LL Bredesen DE Cooper JD Valletta JS Mobley WC Longo FM 1997 Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation J Neurosci 17 7594 7605 9315882 PMC6793892
  146. [155]Volosin M Song W Almeida RD Kaplan DR Hempstead BL Friedman WJ 2006 Interaction of survival and death signaling in basal forebrain neurons: roles of neurotrophins and proneurotrophins J Neurosci 26 7756 7766 16855103 PMC6674285
  147. [156]Podlesniy P Kichev A Pedraza C Saurat J Encinas M Perez B Ferrer I Espinet C 2006 Pro-NGF from Alzheimer’s disease and normal human brain displays distinctive abilities to induce processing and nuclear translocation of intracellular domain of p75NTR and apoptosis Am J Pathol 169 119 131 16816366 PMC1698760
  148. [157]Neeper M Schmidt AM Brett J Yan SD Wang F Pan YC Elliston K Stern D Shaw A 1992 Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins J Biol Chem 267 14998 15004 1378843
  149. [159]Arancio O Zhang HP Chen X Lin C Trinchese F Puzzo D Liu S Hegde A Yan SF Stern A Luddy JS Lue LF Walker DG Roher A Buttini M Mucke L Li W Schmidt AM Kindy M Hyslop PA Stern DM Du Yan SS 2004 RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice EMBO J 23 4096 4105 15457210 PMC524347
  150. [160]Galichet A Weibel M Heizmann CW 2008 Calcium-regulated intramembrane proteolysis of the RAGE receptor Biochem Biophys Res Commun 370 1 5 18355449
  151. [161]Moore SW Tessier-Lavigne M Kennedy TE 2007 Netrins and their receptors Adv Exp Med Biol 621 17 31 18269208
  152. [162]Parent AT Barnes NY Taniguchi Y Thinakaran G Sisodia SS 2005 Presenilin attenuates receptor-mediated signaling and synaptic function J Neurosci 25 1540 1549 15703408 PMC6725985
  153. [163]Tomita T Tanaka S Morohashi Y Iwatsubo T 2006 Presenilin-dependent intramembrane cleavage of ephrin-B1 Mol Neurodegener 1 2 16930449 PMC1513130
  154. [164]Georgakopoulos A Litterst C Ghersi E Baki L Xu C Serban G Robakis NK 2006 Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling EMBO J 25 1242 1252 16511561 PMC1422162
  155. [165]Waschbusch D Born S Niediek V Kirchgessner N Tamboli IY Walter J Merkel R Hoffmann B 2009 Presenilin 1 affects focal adhesion site formation and cell force generation via c-Src transcriptional and posttranslational regulation J Biol Chem 284 10138 10149 19176482 PMC2665068
  156. [166]Litterst C Georgakopoulos A Shioi J Ghersi E Wisniewski T Wang R Ludwig A Robakis NK 2007 Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor J Biol Chem 282 16155 16163 17428795 PMC4005067
  157. [167]Inoue E Deguchi-Tawarada M Togawa A Matsui C Arita K Katahira-Tayama S Sato T Yamauchi E Oda Y Takai Y 2009 Synaptic activity prompts gamma-secretase-mediated cleavage of EphA4 and dendritic spine formation J Cell Biol 185 551 564 19414612 PMC2700400
  158. [168]Ito K Okamoto I Araki N Kawano Y Nakao M Fujiyama S Tomita K Mimori T Saya H 1999 Calcium influx triggers the sequential proteolysis of extracellular and cytoplasmic domains of E-cadherin, leading to loss of beta-catenin from cell-cell contacts Oncogene 18 7080 7090 10597309
  159. [169]Kim DY Ingano LA Kovacs DM 2002 Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage J Biol Chem 277 49976 49981 12376527
  160. [170]Kim DY Ingano LA Carey BW Pettingell WH Kovacs DM 2005 Presenilin/gamma-secretase-mediated cleavage of the voltage-gated sodium channel beta2-subunit regulates cell adhesion and migration J Biol Chem 280 23251 23261 15833746
  161. [171]Cai J Jiang WG Grant MB Boulton M 2006 Pigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1 J Biol Chem 281 3604 3613 16339148
  162. [172]Pelletier L Guillaumot P Freche B Luquain C Christiansen D Brugiere S Garin J Manie SN 2006 Gamma-secretase-dependent proteolysis of CD44 promotes neoplastic transformation of rat fibroblastic cells Cancer Res 66 3681 3687 16585194
  163. [173]Arasada RR Carpenter G 2005 Secretase-dependent tyrosine phosphorylation of Mdm2 by the ErbB-4 intracellular domain fragment J Biol Chem 280 30783 30787 15985438
  164. [174]Junttila TT Sundvall M Lundin M Lundin J Tanner M Harkonen P Joensuu H Isola J Elenius K 2005 Cleavable ErbB4 isoform in estrogen receptor-regulated growth of breast cancer cells Cancer Res 65 1384 1393 15735025
  165. [176]Sturm RA Teasdale RD Box NF 2001 Human pigmentation genes: identification, structure and consequences of polymorphic variation Gene 277 49 62 11602344
  166. [177]Oetting WS King RA 1999 Molecular basis of albinism: mutations and polymorphisms of pigmentation genes associated with albinism Hum Mutat 13 99 115 10094567
  167. [178]Wang R Tang P Wang P Boissy RE Zheng H 2006 Regulation of tyrosinase trafficking and processing by pre-senilins: partial loss of function by familial Alzheimer’s disease mutation Proc Natl Acad Sci U S A 103 353 358 16384915 PMC1326180
  168. [180]Wolfe MS 2008 Inhibition and modulation of gamma-secretase for Alzheimer’s disease Neurotherapeutics 5 391 398 18625450 PMC2572079
  169. [181]Petit A Bihel F Alves da Costa C Pourquie O Checler F Kraus JL 2001 New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage Nat Cell Biol 3 507 511 11331880
  170. [182]Kounnas MZ Danks AM Cheng S Tyree C Ackerman E Zhang X Ahn K Nguyen P Comer D Mao L Yu C Pleynet D Digregorio PJ Velicelebi G Stauderman KA Comer WT Mobley WC Li YM Sisodia SS Tanzi RE Wagner SL 2010 Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer’s disease Neuron 67 769 780 20826309 PMC2947312
  171. [183]Li T Wen H Brayton C Laird FM Ma G Peng S Placanica L Wu TC Crain BJ Price DL Eberhart CG Wong PC 2007 Moderate reduction of gamma-secretase attenuates amyloid burden and limits mechanism-based liabilities J Neurosci 27 10849 10859 17913918 PMC6672827
  172. [184]Araki Y Tomita S Yamaguchi H Miyagi N Sumioka A Kirino Y Suzuki T 2003 Novel cadherin-related membrane proteins, Alcadeins, enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism J Biol Chem 278 49448 49458 12972431
  173. [185]Eggert S Paliga K Soba P Evin G Masters CL Weidemann A Beyreuther K 2004 The proteolytic processing of the amyloid precursor protein gene family members APLP-1 and APLP-2 involves alpha-, beta-, gamma-, and epsilon-like cleavages: modulation of APLP-1 processing by n-glycosylation J Biol Chem 279 18146 18156 14970212
  174. [186]May P Reddy YK Herz J 2002 Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain J Biol Chem 277 18736 18743 11907044
  175. [187]Hoe HS Rebeck GW 2005 Regulation of ApoE receptor proteolysis by ligand binding Brain Res Mol Brain Res 137 31 39 15950758
  176. [188]Stoeck A Shang L Dempsey PJ 2010 Sequential and gamma-secretase-dependent processing of the betacellulin precursor generates a palmitoylated intracellular-domain fragment that inhibits cell growth J Cell Sci 123 2319 2331 20530572 PMC2886747
  177. [189]Blair CR Stone JB Wells RG 2011 The type III TGF-beta receptor betaglycan transmembrane-cytoplasmic domain fragment is stable after ectodomain cleavage and is a substrate of the intramembrane protease gamma-secretase Biochim Biophys Acta 1813 332 339 21167215 PMC3026071
  178. [190]Andersson CX Fernandez-Rodriguez J Laos S Baeckstrom D Haass C Hansson GC 2005 Shedding and gamma-secretase-mediated intramembrane proteolysis of the mucin-type molecule CD43 Biochem J 387 377 384 15540986 PMC1134965
  179. [191]Andersson CX Fernandez-Rodriguez J Laos S Sikut R Sikut A Baeckstrom D Hansson GC 2004 CD43 has a functional NLS, interacts with beta-catenin, and affects gene expression Biochem Biophys Res Commun 316 12 17 15003504
  180. [192]Mambole A Baruch D Nusbaum P Bigot S Suzuki M Lesavre P Fukuda M Halbwachs-Mecarelli L 2008 The cleavage of neutrophil leukosialin (CD43) by cathepsin G releases its extracellular domain and triggers its intramem-brane proteolysis by presenilin/gamma-secretase J Biol Chem 283 23627 23635 18586676 PMC2527098
  181. [193]Lammich S Okochi M Takeda M Kaether C Capell A Zimmer AK Edbauer D Walter J Steiner H Haass C 2002 Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide J Biol Chem 277 44754 44759 12223485
  182. [194]Murakami D Okamoto I Nagano O Kawano Y Tomita T Iwatsubo T De Strooper B Yumoto E Saya H 2003 Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44 Oncogene 22 1511 1516 12629514
  183. [196]Wilhelmsen K van der Geer P 2004 Phorbol 12-myristate 13-acetate-induced release of the colony-stimulating factor 1 receptor cytoplasmic domain into the cytosol involves two separate cleavage events Mol Cell Biol 24 454 464 14673177 PMC303356
  184. [197]Schulte A Schulz B Andrzejewski MG Hundhausen C Mletzko S Achilles J Reiss K Paliga K Weber C John SR Ludwig A 2007 Sequential processing of the trans-membrane chemokines CX3CL1 and CXCL16 by alpha-and gamma-secretases Biochem Biophys Res Commun 358 233 240 17467666
  185. [198]Chu J Jeffries S Norton JE Capobianco AJ Bresnick EH 2002 Repression of activator protein-1-mediated transcriptional activation by the Notch-1 intracellular domain J Biol Chem 277 7587 7597 11739397
  186. [199]Omerovic J Puggioni EM Napoletano S Visco V Fraioli R Frati L Gulino A Alimandi M 2004 Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level Exp Cell Res 294 469 479 15023535
  187. [200]Cowan JW Wang X Guan R He K Jiang J Baumann G Black RA Wolfe MS Frank SJ 2005 Growth hormone receptor is a target for presenilin-dependent gamma-secretase cleavage J Biol Chem 280 19331 19342 15743767
  188. [201]Carey BW Kim DY Kovacs DM 2007 Presenilin/gamma-secretase and alpha-secretase-like peptidases cleave human MHC class I proteins Biochem J 401 121 127 17150042 PMC1698663
  189. [202]Saleh AZ Fang AT Arch AE Neupane D El Fiky A Krolewski JJ 2004 Regulated proteolysis of the IFNaR2 subunit of the interferon-alpha receptor Oncogene 23 7076 7086 15286706
  190. [203]El Fiky A Arch AE Krolewski JJ 2005 Intracellular domain of the IFNaR2 interferon receptor subunit mediates transcription via Stat2 J Cell Physiol 204 567 573 15717316
  191. [204]McElroy B Powell JC McCarthy JV 2007 The insulin-like growth factor 1 (IGF-1) receptor is a substrate for gamma-secretase-mediated intramembrane proteolysis Biochem Biophys Res Commun 358 1136 1141 17524361
  192. [205]Elzinga BM Twomey C Powell JC Harte F McCarthy JV 2009 Interleukin-1 receptor type 1 is a substrate for gamma-secretase-dependent regulated intramembrane pro-teolysis J Biol Chem 284 1394 1409 18996842
  193. [206]Kuhn PH Marjaux E Imhof A De Strooper B Haass C Lichtenthaler SF 2007 Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase J Biol Chem 282 11982 11995 17307738
  194. [207]Chalaris A Gewiese J Paliga K Fleig L Schneede A Krieger K Rose-John S Scheller J 2010 ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by gamma-secretase Biochim Biophys Acta 1803 234 245 20026129
  195. [208]Kasuga K Kaneko H Nishizawa M Onodera O Ikeuchi T 2007 Generation of intracellular domain of insulin receptor tyrosine kinase by gamma-secretase Biochem Biophys Res Commun 360 90 96 17577576
  196. [209]Niwa M Sidrauski C Kaufman RJ Walter P 1999 A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response Cell 99 691 702 10619423
  197. [210]Bloch L Sineshchekova O Reichenbach D Reiss K Saftig P Kuro-o M Kaether C 2009 Klotho is a substrate for alpha-, beta- and gamma-secretase FEBS Lett 583 3221 3224 19737556 PMC2757472
  198. [211]Maretzky T Schulte M Ludwig A Rose-John S Blobel C Hartmann D Altevogt P Saftig P Reiss K 2005 L1 is sequentially processed by two differently activated metal-loproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowth Mol Cell Biol 25 9040 9053 16199880 PMC1265787
  199. [212]Kinoshita A Shah T Tangredi MM Strickland DK Hyman BT 2003 The intracellular domain of the low density lipoprotein receptor-related protein modulates transactiva-tion mediated by amyloid precursor protein and Fe65 J Biol Chem 278 41182 41188 12888553
  200. [213]Liu CX Ranganathan S Robinson S Strickland DK 2007 gamma-Secretase-mediated release of the low density lipoprotein receptor-related protein 1B intracellular domain suppresses anchorage-independent growth of neu-roglioma cells J Biol Chem 282 7504 7511 17227771

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Metadata

Authors
Haapasalo, A., & Kovacs, D. M.
Affiliations
  • Institute of Clinical Medicine – Neurology, University of Eastern Finland, Kuopio, Finland
  • Neurobiology of Disease Laboratory, Genetics and Aging Research Unit, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
Venue
Journal of Alzheimer's Disease
Published
2011-06-14
Volume
25
Issue
1
Pages
3-28
ISSN
  • 1875-8908
  • 1387-2877
Cited by
458
References
12

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