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The Many Substrates of Presenilin/γ-Secretase
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γ-secretase targets many substrates in addition to APP, with consequent impact on a vast array of physiological and pathological processes.
“Like BACE-1, γ-secretase targets many substrates in addition to APP, with the consequent impact on a vast array of physiological and pathological processes (Haapasalo and Kovacs, 2011).”
From Emerging Alternative Proteinases in APP Metabolism and Alzheimer’s Disease Pathogenesis: A Focus on MT1-MMP and MT5-MMP (2019) · cites this paper as Haapasalo and Kovacs, 2011
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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
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Candidate gene for the chromosome 1 familial Alzheimer’s disease locus
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RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain
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A Transcriptively Active Complex of APP with Fe65 and Histone Acetyltransferase Tip60
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Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases
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Molecular pathways to neurodegeneration
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The Low Density Lipoprotein Receptor-related Protein (LRP) Is a Novel β-Secretase (BACE1) Substrate
von Arnim, C. A. F., Kinoshita, A., Peltan, I. D., Tangredi, M. M., Herl, L., Lee, B. M., Spoelgen, R., Hshieh, T. T., Ranganathan, S., Battey, F. D., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m414248200 · Cited by 258
Nicastrin, Presenilin, APH-1, and PEN-2 Form Active γ-Secretase Complexes in Mitochondria
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Presenilin-Dependent -Secretase-Mediated Control of p53-Associated Cell Death in Alzheimer's Disease
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Metadata
- Authors
- Haapasalo, A., & Kovacs, D. M.
- Affiliations
- Institute of Clinical Medicine – Neurology, University of Eastern Finland, Kuopio, Finland
- Neurobiology of Disease Laboratory, Genetics and Aging Research Unit, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
- Venue
- Journal of Alzheimer's Disease
- Publisher
- SAGE Publications
- Published
- 2011-06-14
- Volume
- 25
- Issue
- 1
- Pages
- 3-28
- ISSN
- 1875-8908
- 1387-2877
- PMC
- PMC3281584
- Cited by
- 458
- References
- 12
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