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Sphingomyelin metabolism at the plasma membrane: Implications for bioactive sphingolipids
Open accessAbstract
The plasma membrane (PM) is a major resource for production of bioactive lipids and contains a large proportion of the cellular sphingomyelin (SM) content. Consequently, the regulation of SM levels at the PM by enzymes such as sphingomyelinase (SMase) and SM synthase 2 (SMS2) can have profound effects – both on biophysical properties of the membrane, but also on cellular signaling. Over the past 20 years, there has been considerable research into the physiological and cellular functions associated with regulation of SM levels, notably with regards to the production of ceramide. In this review, we will summarize this research with particular focus on the SMases and SMS2. We will outline what biological functions are associated with SM metabolism/production at the PM, and discuss what we believe are major challenges that need to be addressed in future studies.
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Citations
Cites
Bioactive sphingolipids: metabolism and function
Bartke, N., & Hannun, Y. A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800080-jlr200 · Cited by 683
Self-citationSmith, E. L., & Schuchman, E. H. (2008) · The FASEB Journal · doi:10.1096/fj.08-108043 · Cited by 213
Cited by
Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of Sphingolipidomics
Merrill, A. H. (2011) · Chemical Reviews · doi:10.1021/cr2002917 · Cited by 785
MALDI Imaging of Lipid Biochemistry in Tissues by Mass Spectrometry
Zemski Berry, K. A., Hankin, J. A., Barkley, R. M., Spraggins, J. M., Caprioli, R. M., & Murphy, R. C. (2011) · Chemical Reviews · doi:10.1021/cr200280p · Cited by 386
Biological functions of sphingomyelins
Slotte, J. P. (2013) · Progress in Lipid Research · doi:10.1016/j.plipres.2013.05.001 · Cited by 384
Chung, H.-L., Ye, Q., Park, Y.-J., Zuo, Z., Mok, J.-W., Kanca, O., Tattikota, S. G., Lu, S., Perrimon, N., Lee, H. K., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.03.022 · Cited by 70
Metadata
- Authors
- Milhas, D., Clarke, C. J., & Hannun, Y. A.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2009-10-24
- Volume
- 584
- Issue
- 9
- Pages
- 1887-1894
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1993093223
- Cited by
- 204
- References
- 2
- FWCI
- 4.92
- Type
- journal article
- Language
- en
- Open access
- green
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- Milhas, D., Clarke, C. J., & Hannun, Y. A. (2010). Sphingomyelin metabolism at the plasma membrane: Implications for bioactive sphingolipids. FEBS Letters. https://doi.org/10.1016/j.febslet.2009.10.058
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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