On the biogenesis of myelin membranes: Sorting, trafficking and cell polarity
Open accessAbstract
In the central nervous system, a multilayered membrane layer known as the myelin sheath enwraps axons, and is required for optimal saltatory signal conductance. The sheath develops from membrane processes that extend from the plasma membrane of oligodendrocytes and displays a unique lipid and protein composition. Myelin biogenesis is carefully regulated, and multiple transport pathways involving a variety of endosomal compartments are involved. Here we briefly summarize how the major myelin proteins proteolipid protein and myelin basic protein reach the sheath, and highlight potential mechanisms involved, including the role of myelin specific lipids and cell polarity related transport pathways.
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The lack of profound effects of rhAPOE4-lipids on MAG accentuates the unique functions of MBP in rearranging the cholesterol-rich plasma membrane during compact myelin formation.
“Besides, the lack of profound effects of rhAPOE4-lipids on MAG accentuate the unique functions MBP in rearranging the cholesterol-rich plasma membrane during compact myelin formation (Baron & Hoekstra 2010;Fitzner et al. 2006).”
From Apolipoprotein E ε4 disrupts oligodendrocyte differentiation by interfering with astrocyte‐derived lipid transport (2023) · cites this paper as Baron & Hoekstra 2010
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“Cd42 and Rac1 play a critical role during the early stages of myelination, particularly in compaction [86].”
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Oligodendrocyte-Encoded HIF Function Couples Postnatal Myelination and White Matter Angiogenesis
Yuen, T. J., Silbereis, J. C., Griveau, A., Chang, S. M., Daneman, R., Fancy, S. P. J., Zahed, H., Maltepe, E., & Rowitch, D. H. (2014) · Cell · doi:10.1016/j.cell.2014.04.052 · Cited by 433 · see citing works
Central nervous system myelin: structure, synthesis and assembly
Aggarwal, S., Yurlova, L., & Simons, M. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.06.004 · Cited by 301 · see citing works
Lipids in the nervous system: From biochemistry and molecular biology to patho-physiology
Cermenati, G., Mitro, N., Audano, M., Melcangi, R. C., Crestani, M., De Fabiani, E., & Caruso, D. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.08.011 · Cited by 137 · see citing works
Seiberlich, V., Bauer, N. G., Schwarz, L., Ffrench‐Constant, C., Goldbaum, O., & Richter‐Landsberg, C. (2015) · Glia · doi:10.1002/glia.22832 · Cited by 84 · see citing works
Mok, K. K., Yeung, S. H., Cheng, G. W., Ma, I. W., Lee, R. H., Herrup, K., & Tse, K. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15748 · Cited by 37 · see citing works
- Authors
- Baron, W., & Hoekstra, D.
- Affiliations
- University Medical Center Groningen (NL)
- Corresponding author
- Baron, Wia
- ORCID
- Baron, Wia
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2009-11-05
- Volume
- 584
- Issue
- 9
- Pages
- 1760-1770
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2136251247
- Cited by
- 162
- References
- 3
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 11 · 2023: 10 · 2022: 9 · 2021: 13 · 2020: 12 · 2019: 11 · 2018: 11 · 2017: 10 · 2016: 10 · 2015: 10 · 2014: 13 · 2013: 5 · 2012: 15
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Funders
- Dutch MS Research Foundation
- Netherlands Organization of Scientific Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
- Keywords
- myelin biogenesis, myelin sheath, oligodendrocytes, proteolipid protein, myelin basic protein, membrane trafficking, endosomes, cell polarity, myelin lipids, axonal myelination, central nervous system
- MeSH terms
- Animals, Biological Transport, Cell Membrane, Humans, Models, Biological, Myelin Sheath, Oligodendroglia, Protein Binding, Synapses, Cell Polarity, Membrane Microdomains
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