The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Arginine‐rich cell‐penetrating peptides
Abstract
Arginine‐rich cell‐penetrating peptides are short cationic peptides capable of traversing the plasma membranes of eukaryotic cells. While successful intracellular delivery of many biologically active macromolecules has been accomplished using these peptides, their mechanisms of cell entry are still under investigation. Recent dialogue has centered on a debate over the roles that direct translocation and endocytotic pathways play in internalization of cell‐penetrating peptides. In this paper, we review the evidence for the broad range of proposed mechanisms, and show that each distinct process requires negative Gaussian membrane curvature as a necessary condition. Generation of negative Gaussian curvature by cell‐penetrating peptides is directly related to their arginine content. We illustrate these concepts using HIV TAT as an example.
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Cites
Wadia, J. S., Stan, R. V., & Dowdy, S. F. (2004) · Nature Medicine · doi:10.1038/nm996 · Cited by 1,647
Cited by
Cell-Penetrating Peptides: Design, Synthesis, and Applications
Copolovici, D. M., Langel, K., Eriste, E., & Langel, Ü. (2014) · ACS Nano · doi:10.1021/nn4057269 · Cited by 963
Getting Across the Cell Membrane: An Overview for Small Molecules, Peptides, and Proteins
Yang, N. J., & Hinner, M. J. (2015) · Methods in Molecular Biology · doi:10.1007/978-1-4939-2272-7_3 · Cited by 826
Boeynaems, S., Holehouse, A. S., Weinhardt, V., Kovacs, D., Van Lindt, J., Larabell, C., Van Den Bosch, L., Das, R., Tompa, P. S., Pappu, R. V., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1821038116 · Cited by 482
Recent progress of cell-penetrating peptides as new carriers for intracellular cargo delivery
Wang, F., Wang, Y., Zhang, X., Zhang, W., Guo, S., & Jin, F. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.11.020 · Cited by 377
Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein
Johnson, T. P., Patel, K., Johnson, K. R., Maric, D., Calabresi, P. A., Hasbun, R., & Nath, A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1308673110 · Cited by 265
Metadata
- Authors
- Schmidt, N., Mishra, A., Lai, G. H., & Wong, G. C. L.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2009-11-16
- Volume
- 584
- Issue
- 9
- Pages
- 1806-1813
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2028138612
- Cited by
- 521
- References
- 1
- FWCI
- 9.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schmidt, N., Mishra, A., Lai, G. H., & Wong, G. C. L. (2010). Arginine‐rich cell‐penetrating peptides. FEBS Letters. https://doi.org/10.1016/j.febslet.2009.11.046
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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