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Affibody molecules: Engineered proteins for therapeutic, diagnostic and biotechnological applications
Open accessAbstract
Affibody molecules are a class of engineered affinity proteins with proven potential for therapeutic, diagnostic and biotechnological applications. Affibody molecules are small (6.5 kDa) single domain proteins that can be isolated for high affinity and specificity to any given protein target. Fifteen years after its discovery, the Affibody technology is gaining use in many groups as a tool for creating molecular specificity wherever a small, engineering compatible tool is warranted. Here we summarize recent results using this technology, propose an Affibody nomenclature and give an overview of different HER2‐specific Affibody molecules. Cumulative evidence suggests that the three helical scaffold domain used as basis for these molecules is highly suited to create a molecular affinity handle for vastly different applications.
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Cited by
Affibody Molecules in Biotechnological and Medical Applications
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Self-citationAffibody molecules as engineered protein drugs
Frejd, F. Y., & Kim, K.-T. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.35 · Cited by 225
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Flynn, C. D., Chang, D., Mahmud, A., Yousefi, H., Das, J., Riordan, K. T., Sargent, E. H., & Kelley, S. O. (2023) · Nature Reviews Bioengineering · doi:10.1038/s44222-023-00067-z · Cited by 226
The Dawn of a New Era: Targeting the “Undruggables” with Antibody-Based Therapeutics
Qian, L., Lin, X., Gao, X., Khan, R. U., Liao, J.-Y., Du, S., Ge, J., Zeng, S., & Yao, S. Q. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00915 · Cited by 155
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Metadata
- Authors
- Löfblom, J., Feldwisch, J., Tolmachev, V., Carlsson, J., Ståhl, S., & Frejd, F. Y.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2010-04-11
- Volume
- 584
- Issue
- 12
- Pages
- 2670-2680
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2077787026
- Cited by
- 651
- References
- 0
- FWCI
- 28.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Löfblom, J., Feldwisch, J., Tolmachev, V., Carlsson, J., Ståhl, S., & Frejd, F. Y. (2010). Affibody molecules: Engineered proteins for therapeutic, diagnostic and biotechnological applications. FEBS Letters. https://doi.org/10.1016/j.febslet.2010.04.014
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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