The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids
Abstract
GPR41 is reportedly expressed in murine adipose tissue and mediates short chain fatty acid (SCFA)‐stimulated leptin secretion by activating Gα i. Here, we agree with a contradictory report in finding no expression of GPR41 in murine adipose tissue. Nevertheless, in the presence of adenosine deaminase to minimise Gα i signalling via the adenosine A1 receptor, SCFA stimulated leptin secretion by adipocytes from wild‐type but not GPR41 knockout mice. Expression of GPR43 was reduced in GPR41 knockout mice. Acetate but not butyrate stimulated leptin secretion in wild‐type mesenteric adipocytes, consistent with mediation of the response by GPR43 rather than GPR41. Pertussis toxin prevented stimulation of leptin secretion by propionate in epididymal adipocytes, implicating Gα i signalling mediated by GPR43 in SCFA‐stimulated leptin secretion.
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Brown, A. J., Goldsworthy, S. M., Barnes, A. A., Eilert, M. M., Tcheang, L., Daniels, D., Muir, A. I., Wigglesworth, M. J., Kinghorn, I., Fraser, N. J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211609200 · Cited by 2,409
Self-citationLe Poul, E., Loison, C., Struyf, S., Springael, J.-Y., Lannoy, V., Decobecq, M.-E., Brezillon, S., Dupriez, V., Vassart, G., Van Damme, J., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301403200 · Cited by 1,651
Samuel, B. S., Shaito, A., Motoike, T., Rey, F. E., Backhed, F., Manchester, J. K., Hammer, R. E., Williams, S. C., Crowley, J., Yanagisawa, M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808567105 · Cited by 1,564
Inhibition of Histone Deacetylase Activity by Butyrate
Davie, J. R. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.7.2485s · Cited by 1,515
Effects of sodium butyrate, a new pharmacological agent, on cells in culture
Kruh, J. (1981) · Molecular and Cellular Biochemistry · doi:10.1007/bf00222695 · Cited by 802
Xiong, Y., Miyamoto, N., Shibata, K., Valasek, M. A., Motoike, T., Kedzierski, R. M., & Yanagisawa, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2637002100 · Cited by 731
Acetate and Propionate Short Chain Fatty Acids Stimulate Adipogenesis via GPCR43
Hong, Y.-H., Nishimura, Y., Hishikawa, D., Tsuzuki, H., Miyahara, H., Gotoh, C., Choi, K.-C., Feng, D. D., Chen, C., Lee, H.-G., et al. (2005) · Endocrinology · doi:10.1210/en.2005-0545 · Cited by 612
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Free Fatty Acid Receptors and Drug Discovery
Hirasawa, A., Hara, T., Katsuma, S., Adachi, T., & Tsujimoto, G. (2008) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.31.1847 · Cited by 159
The G-protein-coupled receptor 40 family (GPR40–GPR43) and its role in nutrient sensing
Covington, D. K., Briscoe, C. A., Brown, A. J., & Jayawickreme, C. K. (2006) · Biochemical Society Transactions · doi:10.1042/bst0340770 · Cited by 154
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Cited by
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
den Besten, G., van Eunen, K., Groen, A. K., Venema, K., Reijngoud, D.-J., & Bakker, B. M. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r036012 · Cited by 5,048
Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism
Morrison, D. J., & Preston, T. (2016) · Gut Microbes · doi:10.1080/19490976.2015.1134082 · Cited by 3,781
The role of short-chain fatty acids in microbiota–gut–brain communication
Dalile, B., Van Oudenhove, L., Vervliet, B., & Verbeke, K. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0157-3 · Cited by 3,357
Tolhurst, G., Heffron, H., Lam, Y. S., Parker, H. E., Habib, A. M., Diakogiannaki, E., Cameron, J., Grosse, J., Reimann, F., & Gribble, F. M. (2012) · Diabetes · doi:10.2337/db11-1019 · Cited by 2,404
Metadata
- Authors
- Zaibi, M. S., Stocker, C. J., O'Dowd, J., Davies, A., Bellahcene, M., Cawthorne, M. A., Brown, A. J. H., Smith, D. M., & Arch, J. R. S.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2010-04-20
- Volume
- 584
- Issue
- 11
- Pages
- 2381-2386
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W1979508476
- Cited by
- 340
- References
- 16
- FWCI
- 6.57
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zaibi, M. S., Stocker, C. J., O'Dowd, J., Davies, A., Bellahcene, M., Cawthorne, M. A., Brown, A. J. H., Smith, D. M., & Arch, J. R. S. (2010). Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids. FEBS Letters. https://doi.org/10.1016/j.febslet.2010.04.027
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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