Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism

An obesity-associated gut microbiome with increased capacity for energy harvest

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A metagenome-wide association study of gut microbiota in type 2 diabetes

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Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

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Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

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Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice

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Weight-Reducing Effects of the Plasma Protein Encoded by the <i>obese</i> Gene

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Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease

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Short-Chain Fatty Acids and Human Colonic Function: Roles of Resistant Starch and Nonstarch Polysaccharides

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The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids

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Short-chain fatty acids stimulate glucagon-like peptide-1 secretion via the G-protein-coupled receptor FFAR2

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Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits

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The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition.

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Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium

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Adipose tissue remodeling and obesity

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Regulation of short-chain fatty acid production

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A decrease of the butyrate-producing species <i>Roseburia hominis</i> and <i>Faecalibacterium prausnitzii</i> defines dysbiosis in patients with ulcerative colitis

Machiels, K., Joossens, M., Sabino, J., De Preter, V., Arijs, I., Eeckhaut, V., Ballet, V., Claes, K., Van Immerseel, F., Verbeke, K., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-304833 · Cited by 1,904 · see citing works

Functional Characterization of Human Receptors for Short Chain Fatty Acids and Their Role in Polymorphonuclear Cell Activation

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The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43

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Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults

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Phylogenetic distribution of three pathways for propionate production within the human gut microbiota

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Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation

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<i>Ruminococcus bromii</i> is a keystone species for the degradation of resistant starch in the human colon

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Links between diet, gut microbiota composition and gut metabolism

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Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity

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The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation

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The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents

Psichas, A., Sleeth, M. L., Murphy, K. G., Brooks, L., Bewick, G. A., Hanyaloglu, A. C., Ghatei, M. A., Bloom, S. R., & Frost, G. (2015) · International Journal of Obesity · doi:10.1038/ijo.2014.153 · Cited by 886 · see citing works

Two Routes of Metabolic Cross-Feeding between <i>Bifidobacterium adolescentis</i> and Butyrate-Producing Anaerobes from the Human Gut

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Butyrate enhances intestinal epithelial barrier function via up-regulation of tight junction protein claudin-1 transcription

Wang, H.-B., Wang, P.-Y., Wang, X., Wan, Y.-L., & Liu, Y.-C. (2012) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2259-4 · Cited by 827 · see citing works

Decreased Bacterial Diversity Characterizes the Altered Gut Microbiota in Patients With Psoriatic Arthritis, Resembling Dysbiosis in Inflammatory Bowel Disease

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Diversity of human colonic butyrate‐producing bacteria revealed by analysis of the butyryl‐CoA:acetate CoA‐transferase gene

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High-protein, reduced-carbohydrate weight-loss diets promote metabolite profiles likely to be detrimental to colonic health

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Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults

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Dietary Fiber, Weight Gain, and Cardiovascular Disease Risk Factors in Young Adults

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The role of short chain fatty acids in appetite regulation and energy homeostasis

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Comparison of fermentation reactions in different regions of the human colon

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Acetate and Propionate Short Chain Fatty Acids Stimulate Adipogenesis via GPCR43

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Gut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids

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Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids

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Depletion of Liver Kupffer Cells Prevents the Development of Diet-Induced Hepatic Steatosis and Insulin Resistance

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Increased Proportions of Bifidobacterium and the Lactobacillus Group and Loss of Butyrate-Producing Bacteria in Inflammatory Bowel Disease

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Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk

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Pathways of acetate, propionate, and butyrate formation by the human fecal microbial flora

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Gut Microbiota, Lipopolysaccharides, and Innate Immunity in the Pathogenesis of Obesity and Cardiovascular Risk

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Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells

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Butyrate Inhibits NF-κB Activation in Lamina Propria Macrophages of Patients with Ulcerative Colitis

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The effect of short-chain fatty acids on human monocyte-derived dendritic cells

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Short chain fatty acids exchange across the gut and liver in humans measured at surgery

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Oligofructose promotes satiety in healthy human: a pilot study

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Dietary fiber and subsequent changes in body weight and waist circumference in European men and women

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Lactate is mainly fermented to butyrate by human intestinal microfloras but inter-individual variation is evident

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Microbial Degradation Products Influence Colon Cancer Risk: the Butyrate Controversy

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Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids

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Effect of propionate on fatty acid and cholesterol synthesis and on acetate metabolism in isolated rat hepatocytes

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Control of appetite and energy intake by SCFA: what are the potential underlying mechanisms?

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Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes

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The [13C]acetate breath test accurately reflects gastric emptying of liquids in both liquid and semisolid test meals

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Short-chain free fatty acid receptors FFA2/GPR43 and FFA3/GPR41 as new potential therapeutic targets

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Expression of the short chain fatty acid receptor GPR41/FFAR3 in autonomic and somatic sensory ganglia

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A Role for Gut Microbiota and the Metabolite‐Sensing Receptor GPR43 in a Murine Model of Gout

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Novel Murine Infection Models Provide Deep Insights into the “Ménage à Trois” of Campylobacter jejuni, Microbiota and Host Innate Immunity

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Gut chemosensing mechanisms

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Effect of rectal infusion of short chain fatty acids in human subjects.

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Effects of Propionate on Lipid Biosynthesis in Isolated Rat Hepatocytes

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GPR43 Potentiates β-Cell Function in Obesity

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Kinetic studies on colonocyte metabolism of short chain fatty acids and glucose in ulcerative colitis.

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Topical butyrate improves efficacy of 5‐ASA in refractory distal ulcerative colitis: results of a multicentre trial

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Up-regulation of costimulatory/adhesion molecules by histone deacetylase inhibitors in acute myeloid leukemia cells

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Quantification of in Vivo Colonic Short Chain Fatty Acid Production from Inulin

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Butyrate production from oligofructose fermentation by the human faecal flora: what is the contribution of extracellular acetate and lactate?

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Effect of fat replacement by inulin or lupin-kernel fibre on sausage patty acceptability, post-meal perceptions of satiety and food intake in men

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Kinetic modelling of lactate utilization and butyrate production by key human colonic bacterial species

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Probiotics for weight loss: a systematic review and meta-analysis

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Fecal Acetate Is Inversely Related to Acetate Absorption from the Human Rectum and Distal Colon

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Histone/protein deacetylases and T-cell immune responses

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Topical butyrate for acute radiation proctitis: randomised, crossover trial

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Suppression of monosodium urate crystal-induced cytokine production by butyrate is mediated by the inhibition of class I histone deacetylases

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Randomized clinical trial of laxatives and oral nutritional supplements within an enhanced recovery after surgery protocol following liver resection

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Hepatic Uptake of Rectally Administered Butyrate Prevents an Increase in Systemic Butyrate Concentrations in Humans1–3

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Trends and Dietary Determinants of Overweight and Obesity in a Multiethnic Population

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Probiotics as beneficial agents in the management of diabetes mellitus: a systematic review

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The "Gut Feeling": Breaking Down the Role of Gut Microbiome in Multiple Sclerosis

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Gut Microbiota: A Pivotal Hub for Polyphenols as Antidepressants

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Short-Chain Fatty Acid Aggregates Alpha-Synuclein Accumulation and Neuroinflammation via GPR43-NLRP3 Signaling Pathway in a Model Parkinson’s Disease

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Lower Fiber Consumption in Women with Polycystic Ovary Syndrome: A Meta-Analysis of Observational Studies

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