The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Structural studies of the TGF‐βs and their receptors – insights into evolution of the TGF‐β superfamily
Abstract
TGF‐βs are small secreted signaling proteins that function as vital regulators of cellular growth and differentiation. They signal through a single pair of receptors, known as TβR‐I and TβR‐II, and are among the most recently evolved members of the signaling superfamily to which they belong. This review provides an overview of the TGF‐β, BMP, and activin receptor complexes that have been determined over the past several years. These structures underscore the shared ancestry of the TGF‐βs with the BMPs and activins, but also provide insight as to how the TGF‐βs diverged from the BMPs and activins to bind and assemble their receptors in a distinct manner. These distinctive modes of receptor binding engender the TGF‐βs with high specificity for their receptors and allow them to fulfill their essential functions in vivo without interference from the many other proteins of the superfamily.
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Massagué, J. (2008) · Cell · doi:10.1016/j.cell.2008.07.001 · Cited by 3,907
Kulkarni, A. B., Huh, C. G., Becker, D., Geiser, A., Lyght, M., Flanders, K. C., Roberts, A. B., Sporn, M. B., Ward, J. M., & Karlsson, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.2.770 · Cited by 1,967
Activation of Signalling by the Activin Receptor Complex
Attisano, L., Wrana, J. L., Montalvo, E., & Massagué, J. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.1066 · Cited by 316
Cited by
BMP signalling in skeletal development, disease and repair
Salazar, V. S., Gamer, L. W., & Rosen, V. (2016) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.12 · Cited by 822
Transforming growth factor‐β in stem cells and tissue homeostasis
Xu, X., Zheng, L., Yuan, Q., Zhen, G., Crane, J. L., Zhou, X., & Cao, X. (2018) · Bone Research · doi:10.1038/s41413-017-0005-4 · Cited by 414
TGFβ signaling in cartilage development and maintenance
Wang, W., Rigueur, D., & Lyons, K. M. (2014) · Birth Defects Research Part C: Embryo Today: Reviews · doi:10.1002/bdrc.21058 · Cited by 298
Aykul, S., & Martinez-Hackert, E. (2016) · Analytical Biochemistry · doi:10.1016/j.ab.2016.06.025 · Cited by 284
Aykul, S., & Martinez-Hackert, E. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.713487 · Cited by 143
Metadata
- Authors
- Hinck, A. P.
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2012-05-28
- Volume
- 586
- Issue
- 14
- Pages
- 1860-1870
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2007960009
- Cited by
- 241
- References
- 3
- FWCI
- 6.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hinck, A. P. (2012). Structural studies of the TGF‐βs and their receptors – insights into evolution of the TGF‐β superfamily. FEBS Letters. https://doi.org/10.1016/j.febslet.2012.05.028
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