The DOI matches its Crossref record; 129 of the 129 references it cites were found in a registry or an index.
TGFβ signaling in cartilage development and maintenance
Open accessAbstract
Members of the transforming growth factor beta (TGFβ) superfamily of secreted factors play essential roles in nearly every aspect of cartilage formation and maintenance. However, the mechanisms by which TGFβs transduce their effects in cartilage in vivo remain poorly understood. Mutations in several TGFβ family members, their receptors, extracellular modulators, and intracellular transducers have been described, and these usually impact the development of the cartilaginous skeleton. Furthermore, genome‐wide association studies have linked components of the (TGFβ) superfamily to susceptibility to osteoarthritis. This review focuses on recent discoveries from genetic studies in the mouse regarding the regulation of TGFβ signaling in developing growth plate and articular cartilage, as well as the different modes of crosstalk between canonical and noncanonical TGFβ signaling. These new insights into TGFβ signaling in cartilage may open new prospects for therapies that maintain healthy articular cartilage. Birth Defects Research (Part C) 102:37–51, 2014. © 2014 Wiley Periodicals, Inc.
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Cites
Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus
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The epithelial–mesenchymal transition: new insights in signaling, development, and disease
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Xiong, Y., Mi, B.-B., Lin, Z., Hu, Y.-Q., Yu, L., Zha, K.-K., Panayi, A. C., Yu, T., Chen, L., Liu, Z.-P., et al. (2022) · Military Medical Research · doi:10.1186/s40779-022-00426-8 · Cited by 291
Rivera, K. O., Cuylear, D. L., Duke, V. R., O’Hara, K. M., Zhong, J. X., Elghazali, N. A., Finbloom, J. A., Kharbikar, B. N., Kryger, A. N., Miclau, T., et al. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1190371 · Cited by 22
Metadata
- Authors
- Wang, W., Rigueur, D., & Lyons, K. M.
- Venue
- Birth Defects Research Part C: Embryo Today: Reviews
- Publisher
- Wiley
- Published
- 2014-03
- Volume
- 102
- Issue
- 1
- Pages
- 37-51
- ISSN
- 1542-975X (ISSN-L)
- 1542-9768
- OpenAlex
- W1603728190
- Cited by
- 298
- References
- 129
- FWCI
- 8.70
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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